Genomics England Update September 2020 1 Genomics England

Genomics England Update September 2020 1

Genomics England Key messages 2

Key messages Genomics England 3 Why do we need to change? § We are moving on, from an organisation set up to deliver a project, to a sustainable company § GEL was hugely successful in delivering the 100 K Genomes Project but we are not structured to support our new model, or our future ambitions § We have listened to your feedback to develop our strategy and an operating model which will allow us to deliver on our ambitions. § We have the opportunity to make a significant contribution to the future of healthcare, not only in the UK, but globally. § To deliver, we must be ‘Future Fit’. Change can be tough – but it’s worth the climb. Some things have already changed, and will not change again for the foreseeable future: § In the past year, we have had a new CEO, a new Chair and a new strategy. We have built the foundations for our future and now we can concentrate on delivering on our strategy. To do that, we need the right operating model, and we need to embrace the new ways of working. § We also have a number of new ELT members who have joined since last September. Together with those who have been with GEL for longer, this team have the skills and experience to lead the organisation into the future. § This is a journey which we are all travelling together, and we need everybody to be part of the change.

Key messages Genomics England What does the new model look like? • We’ll all ‘live’ in directorates and sub-groups called chapters, which is a group of people with similar skills. This is where everybody’s day to day admin and management is based. Then, people from different directorates come together to deliver on key elements of our strategy in tribes. • We are not downsizing – in fact there will be more roles in the new organisation structure. This is about making the structure more efficient, and make us better able to deliver, by reorganising and redefining our roles and teams. • New roles will be advertised internally and anybody is welcome to apply for them. However, some roles will be ‘ringfenced’ initially for those who are facing a substantial change to their position at GEL. Our people are critical to our success § Whether a team member has been instrumental in delivering the 100 K Genomes Project, or whether they have joined us more recently to deliver a service for one of our partners, everybody’s contribution is vital. And this doesn’t change. § We appreciate that we are enormously fortunate to have some of the world’s leading talent in science and technology working here at GEL. § It is an absolute priority for us to look after our people. Change is tough, and the new structure will look very different - but we are committed to doing our best for everyone, and supporting those who are facing substantial change, as well as those who continue to contribute in their existing roles. 4

Genomics England An overview of the model 5

A tribe is a group of people working on a big shared goal. The tribe is responsible for delivering one or more services. The tribes align to our strategic goals. A service helps users (internal or external) achieve something. A service is delivered by squads, teams and a service core team (that take action to deliver a service, manage the operations of a service, or generally ensure things are working). Every service is led by a service owner who makes sure that products and supporting actions are ‘joined up’ in how the user experiences them. Directorate A squad scopes, builds and supports product. It is an autonomous, multidisciplinary group of up to 12 people, led by a product manager. Chapter The tribes, services, squads and teams are filled with people from different chapters who share a common skill (e. g. , software engineering, bioinformatics engineering, product management). A group of chapters report into directorates (e. g. , technology). Tribe Service Squad Team Genomics England Service Squad Team A team supports the delivery of an internal or external service. Some teams are single discipline but they often combine complementary skill sets to serve multiple squads or the entire organisation. Teams can be any size.

Genomics England Directorates and Chapters : Your ‘home’ 7

Science and Clinical Directorate Genomics England Mark Caulfield Chapters Lead GEL scientific and clinical thinking Clinical Set scientific strategy and support transformation of genomic healthcare Generate research & evidence to support the NHS Genomic Medicine Service Lead clinical & scientific relationships e. g. Ge. CIP, Devolved Nations, international partnerships R&D Ethics Responsible for ethics, clinical governance and clinical interface with participants’ panel Science Ops 8

Transformation Directorate Genomics England Catherine Byers Chapters Lead and oversee in-year finance, including budget approvals, planning and delegation, partnering, and finance ops. Future years strategic finance. Performance Build quality and assurance into everything we do – using standards to drive performance, not tick boxes Finance Measure and drive performance, and communicate via live, transparent MI Estates Manage estates to ensure fit for purpose, affordable, safe and regulated. Work with People Chapter on driving cultural change, operating model, ways of working Quality, Improvement and Regulations 9

Commercial & Partnerships Directorate Genomics England Parker Moss Chapters Forge partnerships across ecosystem (NHS, Pharma, Tech, Academia, Funders) to advance GEL’s strategy Pharma Partnerships Act as “demanding customer” for research environment and agenda Generate value (and revenue) through partnerships for GEL and wider UK Plc NHS/Academic Partnerships Manage key relationships with most important partners directly Build commercial delivery mindset and “muscle” across GEL Other Ecosystem Partnerships 10

People Directorate Genomics England Nicola Peachey (interim) Chapters Develop and execute strategy for people and culture People Operations Envision and ensure employee experience and (with comms) engagement Manage talent acquisition, onboarding training and development, career paths Talent Management Implement organisational transformation and performance (with transformation) People Partnering 11

Communications & Engagement Directorate Genomics England Anna Tomlinson Chapters Lead patient and participant engagement and dialogue in partnership with NHSE Community Engagement Tell GEL’s story externally through media relations and press office, and stakeholder comms across government, industry, academic and clinical sectors Build meaningful thought leadership and content to be shared through publications, events, website and social media Working closely with the People Team to drive internal engagement, listening and sharing messages with colleagues Public Engagement Marketing 12

Digital Directorate Genomics England Rakhi Rajani Chapters Deliver awesome, innovative services, backed by robust, user-centric tech Service Ownership Embed a human-centric approach to service design, product development and delivery Facilitate an agile, squad-based structure and ways of working that allows us to test, learn and iterate Design and Research Collaborate to develop our product/service vision and strategy Product Management 13

Legal Directorate Genomics England Nick Maltby Chapters Manage legal support for projects (such as property move and partnership contracts) and ensure GEL’s legal compliance Oversee GEL’s contracting and procurement activity including forward planning Act as Data Protection Officer – ensuring compliance with GDPR and reporting to Board Provide secretariat services to GEL Main Board and Audit Committee Legal and procurement 14

Bioinformatics Directorate Genomics England Augusto Rendon Chapters Bioinformatics Ops and Implementation Continuously push for state-of-the-art approaches to help patients and researchers (including harnessing external global network) Incorporate the best genomics, bioinformatics and data science into products and services Oversee standards for genomics and bioinformatics at GEL – and publish and celebrate (with comms and science) cutting edge work Bioinformatics Engineering Genome Analysis Research Bioinformatics Services 15

Tech Directorate Genomics England Pete Sinden Chapters Envision and specify how we architect, build, and run services Technology and Architecture Lead technical design and build of services to meet user needs (developed by Digital) Engineering Run live operations of all technical services whether for customers or staff Data Shape and evolve our data model Design and run cloud infrastructure on which services run Manage security, data governance and compliance with technical standards Assurance and IT Services and Support Delivery Management 16

Genomics England Tribes, Squads, Teams and Services: Your ‘extended family’ 17

Tribes, Services, Squads and Teams : The Structure Tribes Services* Evolving genomic healthcare Accelerating genomic research and advancing the ecosystem Help doctors order genomic tests, receive results and improve patient outcomes Help researchers access data, conduct research, use insights Engage ecosystem partners to advance GEL's mission Team: Core team Team: Scientific R&D Team: Logistics Team: Covid-19 Programme Squad: Test Ordering & Tracking Squad: Clinical data management & de-ID Team: 100 k close down and transition Squad: Interpretation Platform Squad: R. E. 1. 0 Squad: Knowledge management & data services Squad: Bioinformatics Pipeline Squad: COVID 19 R. E. Team: Partnership development Team: Account management Help nontechnical partners achieve their goals Team: Bioinformatics consulting Genomics England Engaging to build trust The GEL Way Empowering our people Help public, patients, participants and partners make informed choices Help colleagues improve their productivity with best practices Help colleagues perform at their best Team: Engagement Team: Core team Team: Partnering Team: Data Strategy Team: Developing People Squad: “Infrastructure as a Service” Squad: "The GEL way" Product, Service & Engineering Practices Team: Engaging People Team: Assurance Team: Supporting People Team: Performance

Genomics England Tribe 1 : Evolving Genomic Healthcare 19

Tribe : Evolving Genomic Healthcare Genomics England Richard Scott Purpose : To deliver the enabling systems, bioinformatics services and insights to help healthcare teams to use genomics to achieve better clinical outcomes: earlier and more precise diagnoses; more effective and costefficient treatment of diseases; and potentially lifestyle interventions. Service Proposed squads and teams Help healthcare profesionals order genomic tests, receive results and improve patient outcomes Create and manage the service through which tests are ordered, samples are processed and interpretable and actionable results are received Core Team Logistics Team Test Ordering & Tracking Squad Clinical data management & de-ID Squad Defines service design & process and develops business cases for the future vision, owning the relationship with NHSE Manages logistics, ensuring every ordered test is received and processed fast and accurately Customers : Clinical requester and genomic lab Design/manage test ordering and tracking systems with NHSE & others Customers: Internal teams and researchers Effective data management curation and presentation Bioinformatics Pipeline Squad Customer: The genomic lab Define and deliver how we meaningfully ingest and translate sequence data Interpretation Platform Squad Customer: The genomic lab Presents data that is returned by bio pipeline to the GLH to allow interpretation and reporting Knowledge Management and Data Services Squad Customer: The genomic lab Responsible for supporting Panel. App, CVA and Cell. Base open. CGA and HTS get

Genomics England Tribe 2 : Accelerating genomic research & advancing the ecosystem 21

Tribe : Accelerating genomic research and advancing the ecosystem Genomics England Parker Moss Purpose : We engage and collaborate with the broad academic community, start-up, bio-tech, pharma and other players in the genomics industry in the UK and beyond in order to advance the UK’s Life Sciences Strategy. We provide access to comprehensive national clinical genomics datasets and provide services to investigate them, collaborate, publish and take action on insights. Service Proposed squads and teams Help researchers access data, conduct research and use insights Creates the product for the research environment, defines and runs programmes and cohorts, ensure data flows to partners in the right way Core Team R. E. 1. 0 Squad Defines the service design and process and the strategy for aligning research endeavours, and owns the relationship with the research community Maintains research environment 1. 0 including products, services, performance and owning relationships with RE users to ensure good accessibility Covid-19 R. E. Squad Covid-19 Programme Team 100 K Close Down and Transition Team Sets up the AWS core platform and the Lifebit platform to enable COVID research in a seamless way for all users Manages the collection, experience and effective use of the data for COVID research, optimising data collation and use whilst managing funding and ensuring full compliance Ensures the data collected for 100 K remains valuable and useful going forward and ensures feedback of additional findings to participants

Tribe : Accelerating genomic research and advancing the ecosystem Genomics England Parker Moss Purpose : We engage and collaborate with the broad academic community, start-up, bio-tech, pharma and other players in the genomics industry in the UK and beyond in order to advance the UK’s Life Sciences Strategy. We provide access to comprehensive national clinical genomics datasets and provide services to investigate them, collaborate, publish and take action on insights. Engage ecosystem partners to advance GEL's mission Service Create new partnerships with academics, commercial partners, start-ups and manages those partnerships to engage new opinions and provide access to our data for medical advancement Proposed squads and teams Scientific R&D Team • • • Strategic planning for sequencing and multi-omics R&D Working closely with others across the company to contribute to a cohesive R&D programme Collaborate with partners to deliver R&D projects Partnership Development Team Account Management Team Develop new relationships with pharma, academia, NHS and start-up community to create a thriving genomics ecosystem Manage logistics and administration with research users, process research, publication proposals and optimise users’ experience with our products and services Significant interrelationship between the two

Tribe : Accelerating genomic research and advancing the ecosystem Genomics England Parker Moss Purpose : We engage and collaborate with the broad academic community, start-up, bio-tech, pharma and other players in the genomics industry in the UK and beyond in order to advance the UK’s Life Sciences Strategy. We provide access to comprehensive national clinical genomics datasets and provide services to investigate them, collaborate, publish and take action on insights. Service Help non-technical partners achieve their goals Support non-technical partners in using Genomics England research resources to maximise their outputs Proposed squads and teams Bioinformatic Consulting Team • • • Bring new products to our partners Help partners achieve their goals Work with partners to consult on how to use our data to solve their problems.

Genomics England Tribe 3 : Engaging to build trust 25

Tribe : Engaging to build trust Genomics England Anna Tomlinson Purpose : With our colleagues in the NHS, we listen to, engage with, and educate participants and patients about the choices they make; whilst providing thought leadership on these sensitive and rapidly evolving topics. Help public, patients, participants and partners make informed choices Service We engage with our partners and the public to share and build knowledge and promote deeper and broader understanding of the genomics ecosystem. Proposed squads and teams Engagement Team • • • Build relationships with participants, patients and the public, creating opportunities for engagement. Work closely with NHSE, DHSC, academic and clinical institutions to share insights, build content and enhance public understanding Design and management of tools to help us achieve these goals, including website and participant portal

Genomics England Tribe 4 : The GEL Way 27

Tribe : The GEL Way Genomics England Rakhi Rajani Purpose : Create our own protocol and tools to build robust, user-centric services and technology to enable genomics healthcare and research Help colleagues improve their productivity with best practices Service Create the protocol for user centric tech, build templates, automate processes, generate our own service principles and quality standards Proposed squads and teams ‘Infrastructure as a Service’ Squad Core Team • Collaboratively and continuously create and articulate best practice ways of working that enable a consistent model for robust, human centred design and delivery of brilliant products and services for GEL • • Provide core underlying capabilities and make them accessible for squads to selfserve Standardise workflow "The GEL way" Squad • • Collaboratively define, capture and mobilise how we actually work and behave aligned to our virtues Define user centric methods, service principles, architecture, tech radar, automation, roadmaps and define how our work aligns to regulatory frameworks Data Strategy Team • • • Recognise that data is at the heart of everything GEL does Define how our data strategy aligns to the wider environment – NHS, GA 4 GH, international, pharma Define how we manage our own data

Genomics England Tribe 5 : Empowering our people 29

Tribe : Empowering our people Genomics England Catherine Byers Purpose : Build a principled and dynamic and ever evolving government company, focused on learning, that attracts and develops the world’s best talent in genomics and related technologies Service Proposed squads and teams Help colleagues perform at their best Create and evolve the mechanisms and working practices that support great performance across GEL, ensuring compliance, safety, security, engagement, wellbeing and commitment Partnering Working with teams in the organisation to ensure excellence, provide support and advice including OD, budgeting, development, business cases and procurement Developing People Ensuring our most important asset – our people – are nurtured, supported and developed Developing systems, practices and L&D that enable us to attract and retain the best people Performance Assurance Providing an ‘xray’ on the business’ to demonstrate progress, provide business intelligence and insights, and drive performance, embedding continuous learning and delivering the transformation. Drive financial insights and analysis Quality assurance of the work that we do and ensuring alignment with and understanding of the regulatory environment within which we operate. Manage risk, legal compliance and governance Supporting People Ensures best use of technology, enabling collaborative working, efficient tech support and opportunities for automation Looks after our physical estates and maintains people processes and information

Genomics England Our strategy and virtues 31

Genomics England 1. Evolving genomic healthcare 2. Accelerating genomic research 6. Advancing the genomics ecosystem 3. Engaging to build trust 4. Scaling user centric tech 5. Empowering our people

Genomics England Speed Focus Curiosity Our virtues Impact Connection Empathy Integrity 33

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