Genome generation Timetable for today Time Activity 00

Genome generation

Timetable for today Time Activity 00: 00 Introduction to the session 00: 10 Story cards 00: 20 Info cards 00: 30 Issue cards 00: 40 Discuss two key issues 00: 45 Feedback your issues

What is DNA?

DNA’s code A C G T

What is a gene? Coding DNA Non-coding DNA Protein

What is a genome?

Genetic variation G A C T A G C T G A T C G A C T A G T C T G A T C

Sequencing technology • Sequencing technology is advancing rapidly. • In 10 years DNA sequencing will become part of routine medical screening. Image by Roy Kaltschmidt, LBNL.

What is genotyping? • Genotyping involves looking at particular regions of the genome that are known to vary between individuals. • Information from genotyping can indicate: – disease risk – drug responsiveness – carrier status for disease – personal traits such as eye colour. Image by Kat M Research, Flickr.

What is genome sequencing? • Genome sequencing involves finding out the whole sequence of a person’s DNA. • Commercially available personal genome sequencing currently costs between £ 6, 000 and £ 12, 000. Image courtesy of Wellcome Library, London

Genes vs environment • A predisposition means that people with a particular genotype tend to have an increased risk of developing a disease. • Lifestyle plays a significant role in increasing or decreasing the risk of developing some diseases. Environment Infectious Disease Obesity Type 2 Diabetes Genes Monogenic

Story cards (10 minutes)

Info cards (10 minutes) How factors k s i r e h t What are ease? s i d t r a e for h Wha t is p harm acog eno What mics ? d medicines e s li a n o s r e p e r A future? e th f o s g u r d e th The g enet ics of br east muc h ca real n gene ly te t ll yo ics alon u? e canc er Genetic counselling ia? hren p o z i h c is s About the risk gene Apo. E-e 4 What is flucloxa cillin?

Issue cards (10 minutes) But, what if…? hat…? Is it right t Wha t wou ld yo u do…? now…? ok Is it better t Who shou ld How know …? woul d you feel… ?

Top issues (5 minutes) • Decide what are the two top issues that come out of the scenario. • Highlight these as they will be used in feedback session. • Remember to write notes throughout the discussion.

Discussion guidelines • Speak for yourself and not for others. • Allow others to finish before you speak. Listen well. • Ask questions (? ? ? ) as well as making statements (!!!) • Explain what you think and feel. • Respect differences in opinion. Find where you agree. • Share your life experiences and knowledge – it is valuable.

Genome generation