GENOME GENERATION Cardbased discussion activity GENOME GENERATION TIMETABLE

GENOME GENERATION Card-based discussion activity

GENOME GENERATION

TIMETABLE FOR TODAY TIME ACTIVITY 00: 00 Introduction to the session 00: 10 Story cards 00: 20 Info cards 00: 30 Issue cards 00: 40 Discussion of two key issues 00: 45 Feedback your issues

WHAT IS DNA?

THE DNA CODE A C G T

WHAT IS A GENE? Coding DNA Non-coding DNA Protein

WHAT IS A GENOME

GENETIC VARIATION G A C T A G C T G A T C G A C T A T C T G A T C

SEQUENCING TECHNOLOGY - Sequencing technology is advancing rapidly. - Within 10 years DNA sequencing will become part of routine medical screening.

WHAT IS GENOTYPING? - Genotyping involves looking at particular regions of the genome that are known to vary between individuals. - Information from genotyping can indicate: • disease risk • drug responsiveness • carrier status for disease • personal traits such as eye colour

WHAT IS GENOME SEQUENCING? - Genome sequencing involves finding out the whole sequence of a person’s DNA. - Commercially available personal genome sequencing currently costs between £ 6, 000 - £ 12, 000.

GENES VS ENVIRONMENT - A predisposition means that people with a particular genotype tend to have an increased risk of developing a disease. Environment Infectious Disease Obesity - Lifestyle plays a significant role in increasing or decreasing the risk of developing some diseases. Type 2 Diabetes Genes Monogenic

STORY CARDS (10 MIN)

INFO CARDS (10 MIN) How m alon uch ca n e re ally genet ic tell you s ? rs sk facto i r e h t re ? What a disease t r a e h for W pha rma hat is cog eno mic enia? ophr z i h c s t is Wha s? medicines d e s li a n o rs e Are p the future? the drugs of The gene tics About the risk gene Apo. E-e 4 of br What i east canc er s flucl oxacill in?

ISSUE CARDS (10 MIN) But, what if… ? t that…? h g i r t i Is Wha t wo uld y ou d o…? …? now k o t r tte be Is it Who s houl How d kn ow… ? wou ld yo u fee l…?

DISCUSSION (10 MIN) - Decide what are the two top issues that come out of the scenario. - Highlight these as they will be used in feedback session. - Remember to write notes throughout the discussion.

DISCUSSION GUIDELINES - Speak for yourself and not for others. - Allow others to finish before you speak. Listen well. - Ask questions (? ? ? ) as well as making statements (!!!) - Explain what you think and feel. - Respect differences in opinion. Find where you agree. - Share your life experiences and knowledge – it is valuable.