Genital Organs Embryology Secondary sex organs Secondary genital

Genital Organs - Embryology Secondary sex organs

Secondary genital organs

Learning objectives Formation of genital ducts Indifferent stage Mesonephric duct derivatives and remnants Paramesonephric duct derivatives and remnants • Anomalies of uterus and vagina • Hermaphroditism • •

Questions • Mesonephric duct • Paramesonephric duct • Hermaphroditism • Anomalies of uterus • Hermaphrodites • Derivatives of paramesonephric duct • Derivatives of mesonephric duct

Timeline of events • Week 3 – IM • Week 4 – genital ridge, mesonephric duct, paramesonephric duct • Week 7 – urogenital sinus • Month 3 – fusion of urethral folds, prostate • Month 5 - vagina

Genital ridge, Nephrogenic cord

Urogenital sinus

In Male embryo

Derivatives of mesonephric duct

In Female embryo

Embryology of vagina

Prostate development

Development of external genetalia

External genitalia • In males • In females

Clinical embryology • • Klinefelters syndrome – 47 XXY Hermaphrodites – True and Pseudo Androgen insesitivity syndrome Mullerian agenesis – Mayer –Rokitansky. Kuster-Hauser Syndrome

Klinefelters syndrome – 47 XXY • • • Nondisjunction in XX. Testicular atrophy, hypogonadism Infertility, gynaecomastia Eunachoid habitus Elevated gonadotrophins Poor secondary sexual charecters

Androgen insensitivity syndrome • • Female, 46 XY, testis Testicular feminisation syndrome Normal Female genitals, breast. Short and blind vagina Absent uterus and tubes/ rudimentary Testis in groin Sexual orientation - female

MRKH syndrome