Genetics 210 Personalized Medicine and Genomics FOR MDS

Genetics 210: Personalized Medicine and Genomics FOR: MDS, PHDS AND CURIOUS STUDENTS SPRING TERM. TUE 2: 15 – 4: 05 THUR. 2: 15 -4: 05 GENOTYPING : $15 COPAY GENE 210. STANFORD. EDU: INFO AND FAQS

Today �Course overview (~30’) �Informed consent (~30’) �How to get genotyped (~10’) �Questions (~15’)

Course Staff �Course Organizers: Stuart Kim (Dev. Bio. , Genetics) Aaron Gitler (Genetics) Rosalind Chuang (Neurology) �TAs: Andrew Roos (Epidemiology) Thomas Roos (Epidemiology)

Published Genome-Wide Associations

Genetics 210: Personalized Medicine and Genomics Diabetes Heart Disease Cancer Alzheimer’s, Parkinson’s/Huntington’s

Human Ancestry

Height prediction

How much Neanderthal are you? Neanderthal George Church, Harvard Geneticist

Stuart All time record

Joint Genotyping Task Force 2008 -2010 Charles Prober Dean Russ Altman Genetics Pat Brown Biochem. Mike Grecius Neur. Carlos Bustamente Gen. Ralph Horwitz Psych Anne James Legal Counsel Stuart Kim Dev. Bio. Phil Lavori HRP Kelly Ormond Genetics Mike Snyder Genetics Keyan Salari Med. School Hank Greely Law School C. Braddock Med School Gil Chu Biochem Sean David Med. School Harry Greenberg Dean Louanne Hudgins Epi Jesse Karmazin Med. School Mark Krasnow Biochem David Magnus Cen. BME Alan Schatzberg Psych. Atul Butte BMI Mildred Cho Pediatrics

Personal Genotyping �Voluntary. You can use a public genome file instead of your own. �Confidential – instructors will not know who opted to be genotyped. �Private – Your own DNA information will not be revealed. �Counseling - genetic counseling via 23 and. Me and medical/psychological counseling via Dr. Alan Schatzberg (Psychology, Stanford).

Introductory Projects �Report on specific genetic locus. Published on SNPedia. com �Class room debate on FDA legislation �Unanticipated opportunities that arise as you explore your genome

Advanced Projects = (project + final) �Annotate whole-genome for Stuart Kim or Aaron Gitler (adopted) �Write a grant for Kaiser-Permanente GWAS (n=110, 000) �Analyze exome sequence data from ALS patients �Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population

Gene 210 Three Manuscripts Textbook Patent Grant i. Phone App in the news � � � � Chicago Medicine Magazine (story on page 18) Salon Web Magazine (9/2013) Stanford Medicine - DNA testing improves learning (8/13) San Jose Mercury News (5/2013) Time (2/2013) Nature USA Today San Francisco Chronicle Recap San Francisco Chronicle Genome Technology Stanford Press Release Nature Blogs LA Times Blog Genome Web Center for Genetics and Society Scientific American

Exploring Personal Genomics Available at Amazon. com

How to get genotyping kits 1. 2. 3. 4. 5. 6. 7. 8. ATTEND THIS INFORMATION SESSION. MAKE CHECK $15 TO STANFORD. BRING CHECK TO KATHY FISHER IN BECKMAN B 300. FILL OUT INFORMED CONSENT FORM BRING SAMPLES BACK TO KATHY B 300 WE WILL SHIP THE GROUP OF SAMPLES BACK TO COMPANY TUESDAY 4 PM FEB. 4 RESULTS IN 6 -8 WEEKS. CLASS STARTS TUESDAY APRIL 1, 2012.

https: //www. 23 andme. com/user/claim/