Genetics 11 1 Gregor Mendel Heredity Inheritance Genetics
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Genetics
11. 1 – Gregor Mendel
Heredity ® Inheritance ® Genetics of traits - study of heredity
Genetics Gregor Mendel ® Suggested genes carry inherited traits. ® Predicted how traits were inherited by studying pea plants
The Role of Fertilization - male and female reproductive cells join to produce a new cell.
The Role of Fertilization
The Role of Fertilization • True-breeding plants • • Trait - a specific characteristic • • Produce offspring identical to parent Ex) Seed color and shape. Varies
The Role of Fertilization • Hybrids - Offspring of parents with different traits.
Quick Graded Review – Two Options – 5 minutes v v 1. Stand speak § Summarize the notes in 15 seconds. § Spend the next 3 minutes preparing what you’ll say. 2. Schoology discussion § Go to Schoology your class Unit 7 11. 1 Summary – First Half § Write a summary of the notes so far in at least 3 sentences. § Do not respond to anyone yet.
Genes and Alleles P gen – Parents • F 1 - Offspring of P generation. • In each cross, one parent’s traits seemed to have disappeared.
Genes and Alleles • Characteristics are determined by genes that are passed from parents to offspring.
Dominant and Recessive Traits • Principle of Dominance – Some alleles are dominant, others are recessive. • Express dominant trait if at least one dominant allele is present. • Express recessive trait if no dominant alleles present • Only recessive alleles present.
Alleles ® Different forms of a gene ® Organisms have two alleles for each trait. ® One from egg. ® One from sperm.
Segregation • What happened to the recessive alleles? • F 1 hybrids self-pollinate. • Offspring of F 1 called F 2 generation.
The F 1 Cross • In F 2 plants, recessive traits reappeared. • ¼ of F 2 plants had recessive trait.
Explaining the F 1 Cross • Alleles segregated, or separate, during formation of the sex cells, or gametes.
Seed shape color Flower position Pod color Pod shape purple axial (side) green inflated white terminal (tips) yellow constricted Plant height Dominant trait round yellow tall Recessive trait wrinkled green short
Quick Graded Review – Two Options – 5 minutes v v 1. Stand speak § Summarize this part of notes in 15 seconds. § Spend the next 3 minutes preparing what you’ll say. 2. Schoology discussion § Go to Schoology your class Unit 7 11. 1 Summary – Second Half § Write a summary of this part of notes in at least 3 sentences. § Or respond add on to someone else’s response from First Half with information from notes.
Recessive attached ear lobes Tongue Roll Dominant trait Dominant Free Ear Lobes Hitch hiker’s thumb Dominant Regular thumb Recessive
Other examples Chin cleft – Dominant Bent pinky finger – Dominant Dimples Blue – Dominant eyes – Recessive Hand clasp – Left thumb dominant Widows peak - Dominant
11. 2 – Applying Mendel’s Principles
Dominant gene (allele) ® Stronger gene ® Represented ® Written by capital letter first ® Example: T for tall plant height
Recessive gene (allele) ® Weaker gene ® Hidden if dominant genes present. ® Represented ® Example: with lower case letters t for short plant height
Pure (Homozygous) ® Two of the same genes (alleles) for a trait ® Example: TT (homozygous dominant) or tt (homozygous recessive)
Hybrid (Heterozygous) ® Two different alleles for a trait ® Example: Tt ® Tall or short?
Probability – The likelihood that an event will occur. Example: Flipping a coin Probability 1 of flipping heads? Number of desired outcomes 2 Number of total possible outcomes
Probability Example: Flipping a coin Probability of flipping heads three times? ½ x ½ = 1/8
Genotype ® Combination of alleles for a certain trait ® Example: Tt, TT, tt
Phenotype ® How it physically looks ® Example: tall, short
Genotype or Phenotype? Tt Genotype Round Phenotype Black Phenotype BB Genotype Smooth Phenotype rr Genotype Tall Phenotype
In pea plants, green (G) pods are completely dominant over yellow (g). What are the genotypes? yellow gg Heterozygous green Gg Homozygous dominant GG Hybrid Gg Homozygous
In pea plants, green pods are completely dominant over yellow. Pure gg yellow Homozygous recessive Pure GG green Heterozygous Yellow gg Gg gg
In guinea pigs, short hair is dominant over long hair What hair length will be represented by a capital S? Short What hair length will be represented by a lower case s? Long
What phenotypes would result from the following genotypes? SS Short hair ss Long hair Ss Short hair
Phenotypes of parents? Tall plant If both parents are pure, what are their genotypes? Which allele will each parent pass on to offspring? Phenotype of offspring? Short plant T T t t T t Genotype of offspring? All tall plants T t
In pea plants, round is dominant over wrinkled texture. What is the genotype of the following? homozygous round RR heterozygous Rr rr wrinkled RR pure dominant hybrid round Rr
In pea plants, round is dominant over wrinkled texture. What is the genotype of the following? pure rr recessive Rr heterozygous round pure wrinkled rr hybrid Rr RR pure round
Punnett Squares ® Punnett squares – predict the result from a cross.
Monohybrid crosses Heterozygous tall parent T T t t T TT Tt tt
How To Make a Punnett Square for a One. Factor Cross Write the genotypes of the parents. Ex) Cross a male and female bird that are heterozygous for large beaks. Genotypes of Bb. Bb x Bb
How To Make a Punnett Square Draw a Punnett square. Put one parent on the top, one parent on the left. Put one allele from each parent on each side of each section.
How To Make a Punnett Square Fill in the table by combining the gametes’ genotypes. Mom Dad
How To Make a Punnett Square -Determine the genotypes and phenotypes of each offspring.
Probability of having… A large beak? A small beak? Homozygous 3: 4 1: 4 dominant? 1: 4 Heterozygous? Homozygous recessive? 2: 4 1: 4
Independent Assortment Principle of independent assortment – genes segregate independently. One gene does not effect another. I. e. - Hair color does not effect eye color.
Dihybrid Cross Two factor cross Two traits involved.
The Two-Factor Cross: F 1 Cross two true-breeding plants: One produced only round yellow peas One produced only wrinkled green peas.
The Two-Factor Cross: F 1 -Round yellow peas had genotype RRYY -Homozygous dominant.
The Two-Factor Cross: F 1 -Wrinkled green peas had genotype rryy - Homozygous recessive
The Two-Factor Cross: F 1 All F 1 offspring were round yellow. Shows yellow and round alleles are dominant over green and wrinkled. Punnett square shows genotype of F 1 offspring as Rr. Yy, heterozygous for both seed shape and seed color.
The Two-Factor Cross: F 2 Crossed F 1 plants to produce F 2 offspring. Crossed Rr. Yy with Rr. Yy
Dihybrid cross instructions Cross the parent alleles. Outside has one of each allele has 4 alleles, two from each parent Mom Inside Dad
The Two-Factor Cross: F 2 Different genes do not influence each other’s inheritance.
The Two-Factor Cross: F 2 Dihybrid cross has 9: 3: 3: 1 ratio. Principle of independent assortment – genes for different traits segregate independently.
11. 3 Other Patterns of Inheritance
Incomplete dominance ® Alleles BLEND (mix) ® Neither gene is dominant ® Heterozygous phenotype is a blend. ® Like colors of paint ®Red + White = Pink
Incomplete Dominance r r www. nerdscience. com R R Rr Rr 11 -3
Codominance ® Both alleles are dominant ® Heterozygous expresses both. ® There is NO “blending” ®Red + White = Red and White
® Red cow + white cow = roan cattle. Roan cattle have both red and white hairs. Codominance
Codominance Example: White chicken (WW) x black chicken (BB) = black and white checkered chicken (BW)
Codominance
Incomplete or Codominance? ®A white cow and a red cow produce a roan cow, one that has both white and red hairs. Codominance ®A red flower and a white flower produce pink flowers. Incomplete ®A black cat and a tan cat produce tabby cats, cats where black and tan fur is seen together. Codominance
Incomplete or Codominance? ®A blue blah bird and a white blah bird produce offspring that are silver. Incomplete ®A certain species of mouse with black fur is crossed with a mouse with white fur and all of the offspring have grey fur. Incomplete ®A woman with blood type A and a man with blood type B have a child with blood type AB. Codominance
Multiple Alleles Single gene with more than two alleles. Trait determined by 2 alleles example: type human blood
Blood Types (codominant) ® Blood type is codominant ® IA and IB are dominant. ® i is recessive ® 4 different blood types Phenotype Genotype (Blood (Alleles or type) genes for blood type) A I AI A, I Ai B I BI B, I Bi AB I AI B O ii
Polygenic Traits controlled by many genes Wide range of phenotypes. example: human skin color has four different genes Skin color genes: Aa. Bb. Cc. Dd
Genes and the Environment Genes provide a plan for development, but also depends on the environment. Both nature and nurture
14. 1 – Human Chromosomes
Karyotype ® Chart of chromosome pairs. ® Shows genome – full set of genetic information.
Karyotype Normal Female
Karyotype Female with Down Syndrome
Sex Chromosomes ®X and Y chromosomes ® Determine the sex of the offspring ® Females are XX ® Males are XY
Sex Chromosomes ® All other chromosomes are autosomes. ® Everyone has 46 chromsomes: 2 sex chromosomes and 44 autosomes.
Sex-linked Traits ® Most inherited on X and Y chromosomes. on X chromosome ® Ex) Color blindness recessive sex-linked trait on X-chromosome ® Males show recessive sex-linked traits more than females
Sex-linked Traits ® Heterozygous carriers females are
X-Chromosome Inactivation In female cells, one X chromosome is randomly switched off, forming a Barr body. Not found in males because only have one X chromosome.
Pedigree Study ® Method of determining the genotype of individuals by looking at inheritance patterns
Male Parents Female Siblings Affected male Affected female Mating Known heterozygotes for recessive allele Death Pedigrees illustrate inheritance
Human Pedigrees This diagram shows what the symbols in a pedigree represent.
Human Pedigrees This pedigree shows how one human trait—a white lock of hair just above the forehead— passes through three generations of a family. The allele for the white forelock trait is dominant.
Human Pedigrees Top of the chart is grandfather with the white forelock trait. Two of his three children inherited the trait. Three grandchildren have the trait, but two do not.
Human Pedigrees Because the white forelock trait is dominant, all family members lacking this trait must have homozygous recessive alleles. One of the grandfather’s children lacks the white forelock trait, so the grandfather must be heterozygous for this trait.
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