General Pathology Histogenetic Classification of Neoplasms Epithelial Neoplasms

General Pathology Histogenetic Classification of Neoplasms Epithelial Neoplasms Jaroslava Dušková Inst. Pathol. , 1 st Med. Faculty, Charles Univ. Prague http: //www 1. lf 1. cuni. cz/~jdusk/

NEOPLASIA – classification HISTOGENETIC v v v mesenchymal epithelial neuroectodermal mixed, teratoma choriocarcinoma mesotelioma

Epithelial Tumours v surface epithelium papillomas carcinomas / papillocarcinomas v glandular epithelium adenomas adenocarcinomas v double diff. mucoepidermoid

Surface Epithelium vsquamous papillomas vtransitional carcinomas / urothelium papillocarcinomas

NEOPLASIA – classification BEHAVIORAL v v v benign borderline malignant histological vs. clinical behaviour

NEOPLASIA – growth benign borderline malignant expansive - locally destructive infiltrative METASTASES

NEOPLASIA – macroscopy mass v ulceration v both v

NEOPLASIA – cytology Benign similar to nonneoplastic Malignant cellular pleomorphism NUCLEAR FEATURES: hyperchromasia (polyploidy, aneuploidy) rough chromatine structure irregular nuclear outline large and/or multiple nucleoli or undifferentiated monotonous cellularity

Malignant Tumour TYPING ICD-O GRADING G 1 G 2 G 3 STAGING p. T p. N p. M Tumour -Noduli-Metastases

Urothelium - Precanceroses u often in the vicinity of the neoplasm bearing the same mutations u precursors of recidives u

Epithelial Tumours v surface epithelium papillomas carcinomas / papillocarcinomas v glandular epithelium adenomas adenocarcinomas v double diff. mucoepidermoid

v chemical v physical - radiation v biological v infectious – oncogenic bacteria & viruses v hormonal

Carcinoma – symptoms & complications u u no mass – pressure, blockade – content/secretion retention - infection u ulceration – bleeding occult/massive – aneamia u cachexia (TNF, cachectin…)

Carcinoma - diagnosis clinical investigation, imaging u cytopathology u histopathology u