Gene Function Role DNA Damage PRKDC GADD 45

Gene Function Role DNA Damage PRKDC GADD 45 A CIB 1 MSH 2 XRCC 5 DNA-PK catalytic subunit CDK Binding Unknown DNA Mismatch Recognition DNA Helicase DNA Damage Signalling DNA Damage Response DNA end joining Mismatch Repair Non-homologous end joining Oxidoreductase d. TMP synthetase Transaminase Glutathione S-transferase Galactosidase Oxidoreductase Ado. Met Synthesis Glyoxalase Peroxidase Fructose Aldolase Biliverdin Reductase Acyl-coenzyme A dehydrogenase Glutathione S-transferase Aldolase Electron Transport Nucleotide Metabolism Amino Acid Metabolism Xenobiotic Metabolism Ganglioside Metabolism Electron Transport Methionine Metabolism Glutathionine Metabolism Hydrogen Peroxide Protection Carbohydrate Metabolism Redox Cycle Fatty Acid Metabolism Amino Acid Catabolism Glycolysis E 3 Ligase Bcl-2 family member DNAse Caspase TNFR family member Apoptosis Anti-Apoptotic DNA Cleavage Pro-Apoptotic Transcription Factor Mitogen Signalling Ras Associated Cadherin Signalling inositide kinase RAN Binding G-Protein Inteferon Receptor Notch Signalling c. AMP Signalling MAPK Signalling Growth Factor Signalling MAPK Signalling Mitogen Signalling JAK/STAT Signalling Metabolism NDUFV 2 TYMS GOT 2 GSTM 3 GLB 1 NDUFS 1 MAT 2 A GLO 1 GPX 4 ALDOC BLVRA ACADS GSTZ 1 ALDOC Apoptosis SIAH 2 BCL 2 L 1 DNASE 1 L 3 CASP 4 SIVA Cell Signalling CREM RREB 1 MAPK 1 GRB 10 MAP 2 K 1 RAB 3 A CTNND 2 PIK 3 CB RANBP 1 GNB 1 IFNAR 2 NOTCH 4 Sub-Polysome Table S 1: m. RNAs Upregulated during TRAIL induced apoptosis