Gaten Matarazzo 6 B Jyoji 11 Manisha 12

Gaten Matarazzo 6 B Jyoji (11), Manisha (12), Sheetal (33), Naila (28)

Who? ● 17 y/o actor ● Lead singer of Work In Progress ● The Blacklist, Stranger Things, Les Miserables etc. ● Suffers from CCD (caused by mutation)

Cleidocranial dysplasia (CCD) ● Birth defect affecting the bones and teeth ● Delayed development of skull ● Collarbones poorly developed or absent → shoulders close to each other ● Common within both genders ● Does not affect intelligence or life span ● Lessen worsening through surgeries

Cause of Cleidocranial dysostosis ● inherited from parents ● mutationin RUNX 2 gene *RUNX 2 gene (on the 6 th chromosome): makes a protein that is involved in the development and maintenance of teeth, bones and cartilage Dominant allele inheritance

Diagnosis of CCD Inherited cases: 1) Pre-birth diagnosis: ultrasound/ genetic testing 2) After-birth diagnosis: genetic testing Mutation cases: 1) Primarily: based on symptoms and X-rays 2) Confirmation: genetics testing CCD affects about one per million people. The RUNX 2 gene is located on the 6 th chromosome

https: //www. youtube. com/watch? v=Vh. GZ 08 Hg. SMM

Matarazzo’s journey ● Not as serious → absence of collarbones and front teeth ● ● ● Benefited his career: started off his acting career Opportunity to talk about CCD, and not be ashamed Had to undergo many surgeries to lessen symptoms Rejected from acting works (lips, teeth, height) Uses dentures

How he helps ● Uses his fame to raise awareness among fans ● Fundraising ○ ○ Dustin-themed merchandise spokesperson for CCD Smiles ● Helps fans feel accepted Gaten Matarazzo wearing the CCD smiles T Shirt

Gaten and Commitment ● Inspirational: talking about his disorder spreading awareness ● Dedicated: want to act in different roles try new things ● Daring knowing his disorder, he still chose acting as a career