G Milton Shy M D 1919 1967 B

G. Milton Shy M. D. 1919 -1967 • • B. Trinidad, Colorado Med School Oregon Wounded US Army WW II as a Dr. in Italy Neurology training in Queens Square & Montreal Neurological Institute 1951 Head of Neurology, U Colorado Described pts with neurodegenerative disorder Now called Shy-Drager Syndrome Orthostasis, ataxia PD, MND 1953 to 1960 Intramural Clinical Director NINDB Son is Michael Shy MD, CMT expert at U Iowa

G. Milton Shy MD 1919 -1967 • • • Muscle Disease interest at MNDB (NIH) Described: – mitochondrial myopathy , – central core myopathy – nemaline myopathy EM of muscles Intracellular recordings from nerves & muscles Classified muscle disease by lesion site: muscle membrane, mitochondria, contractile proteins 1961 Chair Neurology, U of Penn 1967 Chair Neurology, Columbia / Prof NY Neurological Institute Dies of MI in office on top floor, 3 weeks after he arrived. 47 years old Neuro house staff tried to resuscitate him (Roger Rosenberg & Jerry Mendell)

G. Milton Shy M. D Publications A New Congenital Non. Progressive Myopathy Central Core Myopathy Brain. 1956 Dec; 79(4): 610 -21. Nemaline Myopathy. A New Congenital Myopathy Brain. 1963 Dec; 86: 793 -810. Two Childhood Myopathies with Abnormal Mitochondria Brain. 1966 Mar; 89(1): 133 -58.

G. Milton Shy M. D. 1919 - 1967 Students: • • • Andrew Engel (NIH) Daniel Drachman (NIH) David Drachman (NIH) Donald Silberberg (Perelman SOM Univ Penn) Lewis P. Rowland (Penn/Columbia) Stan Appel (Penn) Berch Griggs (NIH) Roger Rosenberg (Columbia) W. King Engel (NIH) (b. St. Louis) – Chief Neurology NINDS 1963 -1978 & at NIH till 1990 – Revolutionized muscle histology & classified muscle disease – Steroids in MG – Acetazolamide in periodic paralysis – RRF in mitochondrial myopathy – 1990 – Present at USC

W. King Engel M. D. Students: • • Robert C. Griggs (Rochester NY) • Michael Brooke (Wash U) • Jerry Mendell (OSU) • Steve Ringel (U of Colo) • John Griffin (Johns Hopkins) • Geroge Karpati (Mc. Gill) • Gerald Fenichel (Vanderbilt) Tulio Bertorini (U of Tenn) • Dale Mc. Farlin (NIH) Michel Fardeau (France) Fernando Tomé (France) David Pleasure (U. Penn) John Morgan-Hughes (England) Barry Festoff (KU) Marcus Dalakas (NIH)

W. King Engel M. D. Publications 1. Adult male and female Neurology. 1969 Mar; 19(3): 221 -33. 2. Diseases of the upper and lower motor neuron Neurology 1969 April; 19(4): 378 The histographic analysis of human muscle biopsies with regard to fiber types 3. Myotonias, myasthenia gravis, and hypokalemic periodic paralysis. Neurology. 1969 May; 19(5): 469 -77 4. Children's biopsies. Neurology. 1969 Jun; 19(6): 591 -605.

W. King Engel Publications . Benefit from Alternate-Day Prednisone in Myasthenia Gravis Acetazolamide Prophylaxis in Hypokalemic Periodic Paralysis N Engl J Med 1972; Jan 6; (286): 17 -20 N Engl J Med 1968; Mar 14; (278): 582 -586

Neuro Family Tree: Decedents of Shy Milton Shy Lewis Rowland King Engel Mendell M. Wicklund A. Amato R. Barohn UTHSCSA UTSW Fellows Griggs J. Kissel Z. Sahenk KUMC Fellows M. Collins

Dr Barohn's Neurophysiology and Neuromuscular Fellows at UTHSCSA and UTSW Carlayne Jackson MD Joanne Janas MD Jonathan Katz MD Larry Ridings MD C Fish Greenfield MD Nabat Jetha MD Stacey B Knobler MD Roberto Nieto MD Noel Baker MD Daniel Krampitz MD Sharon P Nations MD Thomas Salmon MD Bryan Atkinson MD Raul Escobar MD James Herold MD Venna Venkatesh MD Choon Cha MD Anwatul Haq MD David Saperstein MD Ralf Van der Sluis MD Husam Alkersam MD Jay Bauerle MD Yelena Lindenhaum MD Surendra Rao MD Charles Ugokew MD Zabid Cheema MD Suleiman Kojan MD Salil Manek MD Zohair Nanijiani. MD Steven Glusman MD Sanil Mathews MD Jaya Trivedi MD

Dr Barohn's Clinical Neurophysiology and Neuromuscular Fellows in Department of Neurology at KUMC Obi Okankwo- Onuigbo MD Gary Lian MD Ziad Elchami MD Haidar Kabbani MD Hazem Ali MD Christopher Milford MD Blanco Marky DO Sanjeev Kamar MD Yunxia Wang MD Heather Anderson MD Ljaz Rashid MD Sarab Alseoudi MD Saud Khan MD Mamatha Pasnor MD Reddiah Mummaneni MD Dan Dumitru MD Gary Miller MD Kazi Syed MD Ziad Haddad MD Faisal Raja MD James Southwell DO . R. Paduga MD B. Bittel MD B. Zaminiferki MD M. Tahmasbi Sohi MD D. Aggarwal MBBS L. Nayak MBBS A. Abuzinadah MBBS O. Jawdat MD K. Johnson MD T. Quesnell MD D. Jabari MD K. Veerapaneni MBBS E. Bachir MD A. Hamaski MD I. Muzyka MD D. Kimple MD

Michael H. Brooke Publications . Clinical View of Neuromuscular Diseases 2 ND Edition Muscle Biopsy: A Modern Approach