Fraunhofer MEVIS Institute for Medical Image Computing www

Fraunhofer MEVIS Institute for Medical Image Computing www. mevis. fraunhofer. de Bremen / Lübeck - Germany © Fraunhofer

Contents 1. Overview 2. Evolution and structure 3. Fraunhofer MEVIS 4. Innovation chain 5. Perspectives © Fraunhofer

Field of Work Computer assistance for image-based, personalized diagnosis and therapy © Fraunhofer

Til Mette stern © Fraunhofer - April 2005

Characteristics Focus on image-based SW solutions for clinicians n Whole chain: early detection, diagnosis, therapy, monitoring n Epidemiologically important diseases Patient-individual solutions Medicine Transdisciplinary approach Clinical network Science n 150+ clinical and scientific partners worldwide Complete innovation chain n basic research © Fraunhofer research prototype product Industry

Image Modalities Modality 2 -D 3 -D Dynamic [t] Radiography (MX, AX) Computed tomography (CT, CTA) … Magnetic resonance imaging (MRI, MRA) … Ultrasound (US) MR Spectroscopy, Microscopy/Histology, … © Fraunhofer

Why computer support? © Fraunhofer

Why computer support? © Fraunhofer

Dimensions of Competence Methods Me. Vis. Lab Validation Organs Navigation Risk analysis Diseases (Tumor, Inflammation, Degeneration, etc. ) Bones/Joints Visualization Heart/Vessels Quantification Brain Segmentation Lung Registration Liver Modeling/ Simulation Imaging/ Modality © Fraunhofer Clinical Workflow Breast Early Detection Diagnostic Planning Procedure Monitoring Diagnosis Therapy

Fields of Activity n Algorithms, Software Applications & Computing n Visualization & Human Computer Interaction n Workflow, Clinical Usability, … n Intra-operative/-interventional Support n Liver, Lung, Breast, … n Mathematical Modelling & Numerical Simulation n Foundation Professorship at Jacobs University n MR Imaging & Physics n Foundation Professorship at University Bremen n Image Registration n Project Group at University Lübeck © Fraunhofer

2. Evolution and structure © Fraunhofer

Me. Vis Family Tree University Non-profit Commercial : : 2009 2007 2005 2003 2001 1999 1997 1995 1993 © Fraunhofer emerged from daughter of

Structure since 01/2009 50% Bremen 50% Non-profit Commercial (75 employees) (230 employees) Institute for Medical Image Computing Bremen 41% Bremen 51% EFRE NL 100% 50% S-H 50% EFRE © Fraunhofer Project Group Image Registration Lübeck (since 04/2010) Bremen USA Japan

3. Fraunhofer MEVIS © Fraunhofer

Fraunhofer Society Fraunhofer Groups ■ 59 institutes in GER ■ Information & Communication Technology ■ 17 000 employees ■ Life Sciences ■ about 1. 6 billion EUR research budget ■ 2/3 from industry and public agencies ■ Microelectronics ■ Surface Technology & Photonics ■ Production ■ Materials & Components ■ Defense & Security © Fraunhofer

Fraunhofer Society Itzehoe Rostock Bremerhaven 59 Institutes in GER Lübeck Bremen Institutes Branches, Working Groups, Application Centers Berlin Potsdam Hannover Teltow Nuthetal Braunschweig Magdeburg Paderborn Cottbus Oberhausen Halle Dortmund Leipzig Schmallenberg Schkopau Duisburg Dresden Sankt Augustin Aachen Ilmenau Jena Chemnitz Euskirchen Darmstadt Würzburg St. Ingbert Kaiserslautern Saarbrücken Karlsruhe Wertheim Pfinztal Erlangen Nürnberg Stuttgart Freiburg Efringen-Kirchen © Fraunhofer Freising München Holzkirchen

Organization Chart Institute Director Prof. Peitgen Advisory Board Extended Board KG plus Dr. Kuhnigk, Dr. Zidowitz, Person of Trust © Fraunhofer Persons of Trust Management Board (KG) Administration Prof. Peitgen, Prof. Hahn, Prof. Preußer, Prof. Günther, Prof. Fischer, Dr. Kraß, Dr. Lang, Dr. Prause, T. Forstmann

Organization of Work n Team-oriented n Open-minded n Self-organized n Flexible n Adaptive © Fraunhofer

Advisory Board of Fraunhofer MEVIS Chair: Prof. Dr. -Ing. E. R. Reinhardt Research Funding: Dr. R. Jansen Dr. U. Niebling Dr. C. J. G. Evertsz Dr. B. Gewiese Industry: © Fraunhofer Prof. Dr. H. Maier W. Märzendörfer

Advisory Board of Fraunhofer MEVIS Science: Prof. Dr. J. Hennig Prof. Dr. W. A. Kalender Prof. Dr. R. Kikinis Prof. Dr. H. -P. Schlemmer Prof. Dr. H. -P. Bruch Prof. Dr. K. J. Klose Prof. Dr. M. Reiser Prof. Dr. U. Sure Medicine/ Clinic: Uni Bremen: Jacobs University: Prof. Dr. J. Falta © Fraunhofer Dr. A. Ziegler-Jöns Prof. Dr. G. Székely

Management Board © Fraunhofer Prof. Dr. Heinz-Otto Peitgen Institute Director Prof. @ Uni Bremen Prof. @ Uni Boca Raton Prof. Dr. Horst K. Hahn Deputy Institute Director Adj. Prof. @ Jacobs Uni Research Dipl. -Betrw. Thomas Forstmann Head of Administration Prof. Dr. Matthias Günther Head of MR Imaging Found. Prof. @ Uni Bremen Prof. Dr. Tobias Preußer Head of Modeling & Simulation Found. Prof. @ Jacobs Uni Prof. Dr. Bernd Fischer Head of PG Image Registration Head of MIC Institute Prof. @ Uni Lübeck Dr. Stefan Kraß Clinical cooperations Industry projects Publicly funded projects Dr. Markus Lang Scientific personell Industry projects IPR / contracts Dr. Guido Prause Publicly funded projects PR / Advisory Board Deputy Head of Administration

Extended Management Board Persons of Trust Dr. Jan-Martin Kuhnigk IT, Software Development Melanie Bohn Dr. Stephan Zidowitz Quality Management Bianca Lassen Lars Bornemann Dr. Benjamin Geisler © Fraunhofer 22

Finance (MEVIS Bremen) TEUR Inv. BHH HB © Fraunhofer HB HB EFRE HB

Personnel (MEVIS Bremen) MMS: ≈ 230 Ce. Vis: ≈ 10 © Fraunhofer

Certification Certificate for quality assurance (since 2005) n Introduction and application of a quality management system in compliance with n EN ISO 9001 / 12. 2000 n EN ISO 13485 / 07. 2003 (medical devices) Scope: n Research and development for image-based medical diagnosis and therapy n Development of software © Fraunhofer

Awards RSNA 95/97/00 -02: Scientific Exhibit Award with Certificate of Merit (Radiological Society of North America) Oct 1996: Bundesverdienstkreuz erster Klasse für Prof. Peitgen (Bundespräsident Roman Herzog) Dec 1999: Karl Heinz Beckurts-Preis für Forschung und Innovation (Karl Heinz Beckurts-Stiftung) Mar 2005: Magna Cum Laude Award for Most Innovative Contribution (European Congress of Radiology) Apr 2005: Werner Körte Medaille in Gold (Deutsche Gesellschaft für Chirurgie) Mai 2005: Bremer Unternehmerpreis für Wissenstransfer (ASU, BJU) Feb 2006: Induction of Prof. Peitgen into Hall of Fame at FAU Sep 2006: Deutscher Gründerpreis 2006 (Sparkasse, Mc. Kinsey, stern, ZDF) Sep 2007: Eurographics 2007 Medical Prize Nov 2007: Bernd-Artin Wessels-Preis 2007 © Fraunhofer

German Founders Prize 2006 Sep 12, 2006: ZDF studio in Berlin © Fraunhofer

4. Innovation chain © Fraunhofer

Innovation Chain Europe, Asia, USA Clinical Network >150 Siemens Hologic INPUT OUTPUT Invivo Philips Toshiba © Fraunhofer

R&D Structure at Me. Vis Idea Algorithmic Development Customization Integration Algorithm Network Prototype Technical Testing Clinical Evaluation Me. Vis. Lab: SW Platform for R&D, Prototyping, Evaluation & Integration © Fraunhofer : : Product

Publicly Funded Projects BMBF: DFG: EU: Andere: J © Fraunhofer FUSION (6, 75 Wi. Mi + 1 MTRA) kostenn. Verlängerung DOT-MOBI mit DKFZ, ITWM, MMS und Siemens (6 Wi. Mi) Kompetenznetz ASTHMA-MRI mit 6 klin. Partnern (1 Wi. Mi) Lung. Sys mit 12 Partnern (1 Wi. Mi) PMRIT: Physiological MRI during Throbolysis (1, 5 Wi. Mi) Virtuelle Leber: Mathematische Modellierung der Leber mit div. Partnern (3, 7 Wi. Mi) bis 03/2015 Spitzencluster: Medical Valley mit Siemens, IIS und div. Partnern (1, 5 Wi. Mi) bis 09/2013 Mo. Bi. Tech 3: MALDI-AMK mit Bruker, Ze. Te. M, CUCA u. a. (1 Wi. Mi) bis 12/2013 RFITT mit UKBF (0, 5 Wi. Mi) Klinische FG Essen: LLS/A 2 - OP (1 Wi. Mi) kostenn. Verlängerung Klinische FG Essen: LLS/B 2 - Histologie (1 Wi. Mi) Lunge/COPD mit DKFZ (1 Hi. Wi) Lungenchirurgieplanung (1 Wi. Mi + 0, 5 MTRA + 1 Hi. Wi) Neurochirurgie-Risikoanalyse mit Marburg (1 Wi. Mi + 1 Hi. Wi) HAMAM mit EIBIR-Partnern und Industrie (2 Wi. Mi) ESFRI: Euro-Bio. Imaging mit EIBIR-Partnern (0, 1 Wi. Mi) bis 07/2013 ICT-VPH: FUSIMO mit Uni Dundee, TU Delft, SINTEF u. a. (3 Wi. Mi) bis 12/2013 R. -Bosch-Stiftung: OP-Projektion mit Prof. Lamade, RBKH Stuttgart (0, 4 Wi. Mi) WFB: 3 D-MALDI mit Ze. Te. M und Bruker (0, 2 Wi. Mi) DHZB: Cardio-MRI in Congenital Heart Disease (0, 8 Wi. Mi) F M A M J J A S O N D J F M A M J J A S 2009 2010 2011 2012 O N D

Cooperations with Industry Fraunhofer MEVIS n MMS AG n Siemens AG n Stryker n several others in publicly funded projects OEM partners of MMS AG n Siemens AG n Hologic n Philips/ Invivo n Toshiba © Fraunhofer

Three Success Stories Market share Breast-MRI - Neoangiogenesis and Biopsy >50% Breast Cancer Screening >50% - Digital Mammography Surgery Planning - Internet-based Service © Fraunhofer >90%

1. Breast-MRI: Tumor Dynamic & Biopsy © Fraunhofer

2. Mammography Workstation Softcopy reading in digital mammography First prototype: master thesis EU Projects: - SCREEN-TRIAL Mammography Screening Bremen Today: World market leader with over 6. 000 systems Siemens: Mammo. Report. Plus Reporting Station Hologic: LORAD Selenia Reporting Station © Fraunhofer

3. Liver Surgery Planning © Fraunhofer

Distant Service via Internet USA Japan Europe Korea Egypt Australia China Singapore © Fraunhofer certified Taiwan

150+ Users Worldwide Asia, USA, Europe Germany › Kyoto University Hospital, Japan › Charité Berlin, Campus Benjamin Franklin › Yokohama City University Medical School, Japan › Charité Berlin, Campus Buch › Nagoya University Hospital, Japan › Charité Berlin, Campus Virchow Status since 2003: > 5. 000 plannings at Me. Vis › University Hospital Kanazawa, Japan › Allgemeines Krankenhaus Celle › Kaohsiung University Hospital, Kaohsiung, Taiwan › Universitätsklinikum Essen › Lahey Clinic, Burlington, MA, USA › Johann Wolfgang Goethe Universität Frankfurt › Massachusetts General Hospital, Boston, MA, USA › Universitätsklinik Freiburg › University of California at San Francisco, USA › Medizinische Hochschule Hannover › Columbia University, USA › Klinikum Hof › University of Michigan, USA › Universitätsklinik Köln › Universtity of California at Los Angeles, USA › Klinikum Krefeld › Washington University St. Louis, USA › Klinikum Schleswig-Holstein, Campus Lübeck › Strong Memorial Hospital, Rochester, NY, USA › Universitätsklinikum Mainz › NIH Clinic, Bethesda, MD, USA › Klinikum der Philipps-Universität Marburg › State University Hospital, Groningen, Netherlands › Klinikum rechts der Isar München › Lund University Hospital, Sweden › Universitätsklinik Tübingen ≈ 2. 400 LDLTs ≈ 1. 900 Tumor resections ≈ 700 Pancreas, kidney, spleen, … › Verona University Hospital, Verona, Italy › Naples University Hospital, Naples, Italy › Univerity Hospital Sapienza Rome, Italy › Gleneagles Hospital, Singapore © Fraunhofer

5. Perspectives © Fraunhofer

Perspectives New fields n Modeling and simulation n MR imaging n Image registration Personnel n 82+ employees until 2013 at Fraunhofer MEVIS MR Scanner Me. Vis Campus © Fraunhofer

Modeling and Simulation Jacobs University Bremen Foundation professorship by Conrad and Lotti Naber Modeling of bio-physical processes Numerical simulation Examples n RF-Ablation of liver tumors n Numerical flow simulation n High focused ultrasound © Fraunhofer Prof. Dr. Tobias Preußer

MR Imaging & Physics University Bremen – FB Physics Foundation professorship by Stiftung Bremer Wertpapierbörse Optimization of imaging Development of new sequences and imaging protocols Examples n Arterial Spin-Label Imaging n Diffusion Tensor Imaging © Fraunhofer Prof. Dr. Matthias Günther

Image Registration Fraunhofer MEVIS – Project Group Lübeck University Lübeck – Institute of Mathematics Basic funding by State Schleswig-Holstein Anatomically correct mapping and fusion of medical image data Examples Prof. Dr. Bernd Fischer n Registration of pre-, intra- und postoperative images n Multimodal image registration © Fraunhofer

www. mevis. fraunhofer. de EUROPEAN UNION: Investing in your future European Regional Development Fund © Fraunhofer