Food Drug Interaction Impact on the Heart By

Food & Drug Interaction Impact on the Heart By: Emily Bernhardt HW 499_Unit 4_Power Point

Food & Drug Interaction Obesity Ø “More than 35% of U. S. adults are obese” Ø “Persons with a body mass index (BMI) of >30 have a reduced life expectancy of 2– 4 years less than compared with healthy weight adults; adults with severe obesity (BMI >40) lose 8 -10 years of life expectancy, comparable to the effects of smoking” Ø “On its current trajectory, it is estimated that obesity rates for adults could reach or exceed 44% in every state by 2030” (American Heart Association, 2013)

Food & Drug Interaction Heart Disease • “Nearly 84 million U. S. adults suffer from cardiovascular diseases (CVD)” • “These life-threatening conditions include coronary heart disease, heart failure, stroke, and high blood pressure” • “According to a 2012 analysis, sedentary behavior is associated with a 147% increase in the risk of CVD, 90% increase in the risk of CVD mortality, and a 49% increase in the risk of all-cause mortality” (American Heart Association, 2013).

Food & Drug Interaction Anticoagulants-a blood thinners Commonly prescribed: Ø Dalteparin (Fragmin), Danaparoid (Orgaran) Ø Enoxaparin (Lovenox) Ø Heparin (various) Ø Tinzaparin (Innohep) Ø Warfarin (Coumadin)

Food & Drug Interaction COUMADIN (WARFARIN)

Coumadin • Contains an active ingredient called Warfarin Sodium. • When taking Coumadin you do not want to take other medication that contains Warfarin Sodium. • Many other medicines, as well as food, beverages and some supplements can interact with COUMADIN and impact the dose you need or increase COUMADIN side effects (FDA, 2013)

Foods & Beverage interaction with Coumadin • Vitamin K-rich foods, • Some vegetable oils: (canola oil, soybean oil) Warfarin less effective, increasing the risk of blood clots. • Cranberry juice and cranberry products Increases the risk of bleeding.

Foods & Beverage interaction with Coumadin • Garlic and ginger Increases the risk of bleeding and reduces warfarin’s effectiveness. • Alcohol More than three alcoholic drinks per day, enhances blood thinning. • More information: http: //www. med. unc. edu/im/files/ patient-educationhandouts/nutrition-and-dietfiles/Vitamin%20 K%20%20 Content %20 of%20 Common%20 Foods. pdf

Supplements interaction with Coumadin • Herbal teas, green tea, St. John's Wort & Coenzyme Q -10 Can make warfarin more or less effective. • Gingko Increases the risk of bleeding. • Ginseng Decreases the effectiveness of warfarin. • Glucosamine Reduces warfarin’s effectiveness (Harvard Heart Letter, 2013)

“Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 -800 -FDA-1088” (FDA, 2013). FOOD & DRUG INTERACTION

References: American Heart Association (AHA). (2013). Cardiac Medications. Received August 18, 2013 from http: //www. heart. org/HEARTORG/Conditions/Heart. Attack/Prevention. Treatmentof. Heart. Attack/Cardiac. Medications_UCM_303937_Article. jsp American Heart Association (AHA). (2013). FACTS-Breaking Our Hearts: Still America’s No. 1 Killer NIH Funding for Heart and Stroke Research. Received August 18, 2013 from http: //www. heart. org/idc/groups/heart-public/@wcm/@adv/documents/downloadable/ucm_304822. pdf American Heart Association (AHA). (2013). FACTS : With a Very Heavy Heart, Obesity and Cardiovascular Disease (CVD). Received August 18, 2013 from http: //www. heart. org/idc/groups/heartpublic/@wcm/@adv/documents/downloadable/ucm_305059. pdf Food and Drug Administration (FDA). (2013). Medication Guide: Coumadin. Received August 18, 2013 from http: //www. fda. gov/downloads/Drug. Safety/ucm 088578. pdf Med UNC. (2013). Vitamin K Content of Common Foods. Received August 2, 2013 from http: //www. med. unc. edu/im/files/patient-education-handouts/nutrition-and-dietfiles/Vitamin%20 K%20%20 Content%20 of%20 Common%20 Foods. pdf Harvard Heart Letter. (2013, June 1). Avoid these with heart medications. Received August 18, 2013 from http: //ehis. ebscohost. com. lib. kaplan. edu/eds/pdfviewer? sid=c 9492 d 79 -c 8 f 4 -468 c-9 d 9925283 a 8 fc 92 a%40 sessionmgr 15&vid=7&hid=15 Tufts University Health & Nutrition Letter. (2013, May 1). Understanding Food and Medication Interactions. Received August 18, 2013 from http: //ehis. ebscohost. com. lib. kaplan. edu/eds/detail? vid=4&sid=c 9492 d 79 -c 8 f 4468 c-9 d 9925283 a 8 fc 92 a%40 sessionmgr 15&hid=15&bdata=Jn. Npd. GU 9 ZWRz. LWxpdm. U%3 d#db=hxh&AN=87374640