FOCUS ON ORAL MICROBIOME Core microbiome Variable microbiome

FOCUS ON ORAL MICROBIOME Core microbiome + Variable microbiome

ORAL MICROBIOME COMPOSITION: BACTERIA Most represented genera: Streptococcus, Prevotella, Haemophilus, Rothia, Veillonella, Neisseria, Fusobacterium, Porphyromonas http: //www. homd. org

ORAL MICROBIOME COMPOSITION: FUNGI doi: 10. 1371/journal. ppat. 10007130

ORAL MICROBIOME COMPOSITION: ARCHEA Methanobrevibacter, Methanobacterium, Methanosarcina, Methanosphaera doi. org/10. 1016/j. anaerobe. 2011. 03. 001

ORAL MICROBIOME COMPOSITION: VIRUSES HSV (Herpes Simplex Virus): primary herpetic gingivostomatitis, mucocutaneous orofacial disease and recurrent lesions on the face and lips HPV (Human Papilloma Virus): benign-like oral papillomas, oral condylomas and focal epithelial hyperplasia HIV: oral candidiasis, oral hairy leukoplakia, linear gingival erythema and necrotizing ulcerative periodontitis

LOCATION OF ORAL MICROBIOTA: DOI: 10. 1038/sj. bdj. 2018. 217

LOCATION OF ORAL MICROBIOTA: SALIVA Streptococcus spp. Veillonella spp. Prevotella spp. DOI: 10. 1177/154405910808701104

LOCATION OF ORAL MICROBIOTA: SURFACES OF SOFT TISSUES Streptococcus salivarius, Rothia mucilaginosa, Eubacterium (strain FTB 41) DOI: https: //doi. org/10. 1016/j. it. 2017. 08. 005

LOCATION OF ORAL MICROBIOTA: SURFACES OF HARD TISSUES DOI: 10. 1158/1055 -9965. EPI-16 -0538

Biofilm formation

Microbial complexes in subgingival plaque. Socransky SS

Endogenous and exogenous factors affecting oral microbiota Diet: S. mutans and F. nucleatum Smoking: Bacillus spp. and Clostriudium spp. Drinking: liquor and wine Antibiotic use Pregnancy: P. gingivalis, A. actinomycetemcomitans, P. intermedia and F. nucleatum

ORAL MICROBIOTA and DISEASES: DENTAL CARIES S. mutans Lactobacillus spp. Veillonella spp. , Bifidobacterium spp. , Propionibacterium (Cutibacterium) spp. , Non-S. mutans Streptococci, Actinomyces spp. , Atopobium spp. doi. org/10. 1177/0022034510379602

ORAL MICROBIOTA and DISEASES: PERIODONTAL DISEASES Gingivitis: TM 7 Leptotrichia, Selenomonas, Streptococcus, Veillonella, Prevotella, Lautropia, Haemophilus Parodontotis: Red complex C. albicans Doi: 10. 1016/j. imlet. 2014. 08. 017 CMV HSV EBV

ORAL MICROBIOTA and DISEASES: Recurrent aphthous stomatitis Prevotella spp. Rothia spp. DOI: 10. 1177/0022034514565458

ORAL MICROBIOTA and DISEASES: Oral tumor Streptococcus spp. Gemella spp. Granulicatella adiacens Capnocytophaga gingivalis DOI: https: //doi. org/10. 1186/1471 -2180 -12 -144

ORAL MICROBIOTA and SYSTEMIC DISEASES: Diabetes Subgingival plaque Supragingival plaque Treponema denticola, Prevotella nigrescens, Streptococcus sanguinis, Streptococcus oralis, Streptococcus intermedius doi: 10. 1111/j. 1600 -0765. 2012. 01498. x

ORAL MICROBIOTA and SYSTEMIC DISEASES: Cardiovascular diseases doi. org/10. 1016/j. puhe. 2007. 004 Atherosclerotic plaques: Veillonella, Streptococcus, P. gingivalis, A. actinomycetemcomitans, T. forsythia, E. corrodens, F. nucleatum, and Campylobacter rectus Unstable atherosclerotic plaques and thrombi of patients with acute myocardial infarction: P. gingivalis

ORAL MICROBIOTA and SYSTEMIC DISEASES: Tumors of distant organs