Figure 8 1 The Biology of Cancer Garland
Figure 8. 1 The Biology of Cancer (© Garland Science 2007)
Figure 8. 3 b The Biology of Cancer (© Garland Science 2007)
Kinetics of Cyclin D 1 after mitogenic stimulus Figure 8. 8 The Biology of Cancer (© Garland Science 2007)
Many Growth Factor-Stimulated Pathways Upregulate Cyclin D
Waxing & Waning of Cyclin-CDK Complexes Figure 8. 12 The Biology of Cancer (© Garland Science 2007)
Families of Cyclin-CDK Inhibitors
Figure 8. 14 a The Biology of Cancer (© Garland Science 2007)
Figure 8. 15 a The Biology of Cancer (© Garland Science 2007)
Recall the AKT/PKB – m. TOR Axis Figure 16. 44 a The Biology of Cancer (© Garland Science 2007)
AKT Directs Growth-Sparing Compartmentation of p 27 Kip 1 (and p 21 Cip 1 too) Figure 8. 16 b The Biology of Cancer (© Garland Science 2007)
Paradoxical Effects of p 21 and p 27 on Cyclin DCDK 4/6 VS other Cyclin-CDKs Figure 8. 17 a The Biology of Cancer (© Garland Science 2007)
Rb’s Actions are Regulated by its State of Phosphorylation
Phosphorylation Determines Rb-E 2 F Interaction Figure 8. 22 The Biology of Cancer (© Garland Science 2007)
+ Feedback loop Cyc E-CDK 2 Promotes Destruction of p 27 Cyclin E transcription Figure 8. 25 b The Biology of Cancer (© Garland Science 2007)
The Rb Family of Pocket Proteins p 105 (Rb); p 107 & p 130 Figure 8. 21 a The Biology of Cancer (© Garland Science 2007)
E 2 F/DP and Transcription (Associated with Hypophosphorylated Rb family members) (Free E 2 F-DP complexes)
During G 1 Cooperation Among Pathways (mostly) Favors D 1 Accumulation Figure 8. 26 The Biology of Cancer (© Garland Science 2007)
Myc, Max & Mad-Max Figure 8. 27 The Biology of Cancer (© Garland Science 2007)
Myc & Its Collaborators Promote D/CDK & Decrease Rb Inhibition of R Point Transit Figure 8. 28 The Biology of Cancer (© Garland Science 2007)
TGFβ can Trump Myc Figure 8. 31 The Biology of Cancer (© Garland Science 2007)
Myc can Influence Differentiation Figure 8. 34 The Biology of Cancer (© Garland Science 2007)
A Web of Interactions & Pathways Influence R Point Transition Figure 8. 35 The Biology of Cancer (© Garland Science 2007)
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