Figure 8 1 The Biology of Cancer Garland

Figure 8. 1 The Biology of Cancer (© Garland Science 2007)

Figure 8. 3 b The Biology of Cancer (© Garland Science 2007)

Kinetics of Cyclin D 1 after mitogenic stimulus Figure 8. 8 The Biology of Cancer (© Garland Science 2007)

Many Growth Factor-Stimulated Pathways Upregulate Cyclin D

Waxing & Waning of Cyclin-CDK Complexes Figure 8. 12 The Biology of Cancer (© Garland Science 2007)

Families of Cyclin-CDK Inhibitors

Figure 8. 14 a The Biology of Cancer (© Garland Science 2007)

Figure 8. 15 a The Biology of Cancer (© Garland Science 2007)

Recall the AKT/PKB – m. TOR Axis Figure 16. 44 a The Biology of Cancer (© Garland Science 2007)

AKT Directs Growth-Sparing Compartmentation of p 27 Kip 1 (and p 21 Cip 1 too) Figure 8. 16 b The Biology of Cancer (© Garland Science 2007)

Paradoxical Effects of p 21 and p 27 on Cyclin DCDK 4/6 VS other Cyclin-CDKs Figure 8. 17 a The Biology of Cancer (© Garland Science 2007)

Rb’s Actions are Regulated by its State of Phosphorylation

Phosphorylation Determines Rb-E 2 F Interaction Figure 8. 22 The Biology of Cancer (© Garland Science 2007)

+ Feedback loop Cyc E-CDK 2 Promotes Destruction of p 27 Cyclin E transcription Figure 8. 25 b The Biology of Cancer (© Garland Science 2007)

The Rb Family of Pocket Proteins p 105 (Rb); p 107 & p 130 Figure 8. 21 a The Biology of Cancer (© Garland Science 2007)

E 2 F/DP and Transcription (Associated with Hypophosphorylated Rb family members) (Free E 2 F-DP complexes)

During G 1 Cooperation Among Pathways (mostly) Favors D 1 Accumulation Figure 8. 26 The Biology of Cancer (© Garland Science 2007)

Myc & Its Collaborators Promote D/CDK & Decrease Rb Inhibition of R Point Transit Figure 8. 28 The Biology of Cancer (© Garland Science 2007)

A Web of Interactions & Pathways Influence R Point Transition Figure 8. 35 The Biology of Cancer (© Garland Science 2007)