Figure 5 SOX 9 expression does not depend

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Figure 5. SOX 9 expression does not depend on RET signalling. (A and B)

Figure 5. SOX 9 expression does not depend on RET signalling. (A and B) Ret expression remains unaffected in Sox 8/9. . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 1. Sox 8 and Sox 9 are expressed in a highly dynamic pattern

Figure 1. Sox 8 and Sox 9 are expressed in a highly dynamic pattern during kidney development. (A) Whole-mount ISH at E 11. . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 6. SOX 8/9 regulate downstream targets of RET signalling. Expression of Etv 5

Figure 6. SOX 8/9 regulate downstream targets of RET signalling. Expression of Etv 5 (A and B), Cxcr 4 (C and D) and. . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3. Tissue-specific ablation of Sox 8 and Sox 9 leads to renal agenesis.

Figure 3. Tissue-specific ablation of Sox 8 and Sox 9 leads to renal agenesis. (A and B) Macroscopic analysis at E 18. 5. . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4. Tissue-specific deletion of Sox 9 in the absence of Sox 8 results

Figure 4. Tissue-specific deletion of Sox 9 in the absence of Sox 8 results in a hypoplastic kidney phentoype. (A and B). . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2. Sox 8 and Sox 9 are required for ureter branching. (A and

Figure 2. Sox 8 and Sox 9 are required for ureter branching. (A and B) Histological analysis showing a blind ending. . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 7. Abnormal induction of nephrogenesis at late stages of development in Sox 8/Sox

Figure 7. Abnormal induction of nephrogenesis at late stages of development in Sox 8/Sox 9 knockout kidneys. (A and B). . . Hum Mol Genet, Volume 20, Issue 6, 06 January 2011, Pages 1143– 1153, https: //doi. org/10. 1093/hmg/ddq 558 The content of this slide may be subject to copyright: please see the slide notes for details.