Figure 3 B KIT Mast cell KIT Skin

Figure 3 B KIT (Mast cell) KIT (Skin) KIT +/+ KIT D 17/+ KIT Dup/+ 1 2 3 0. 3893618 0. 4056964 0. 5446244 0. 5859527 0. 6872258 0. 8460743 0. 3824474 0. 4464798 0. 5776948 1. 0783732 0. 5208198 1. 1398621 0. 4084981 0. 3886832 0. 5408624 1. 4427850 1. 0561863 0. 9585039 AVERAGE 0. 3934358 0. 4136198 0. 5543939 1. 0357036 0. 7547440 0. 9814801

Figure 3 D KIT +/+ KIT D 17/+ KIT DUP/+ AVERAGE STD KIT 0. 8499456433 0. 0519585565 0. 7628199193 0. 0354716199 0. 9294261795 0. 0139403599 KIT(p) 0. 7135147909 0. 0469382296 0. 4374522022 0. 0135511934 0. 8455654028 0. 0409830613 DCT 0. 8541577177 0. 0561025386 0. 6634832767 0. 0920673198 0. 8565525767 0. 1137588184 Melan. A 0. 9943852151 0. 0446778525 0. 6252874151 0. 0824521385 1. 2175671453 0. 1315487549 AKT 1. 2198235564 0. 0186319570 1. 2236495808 0. 0332733759 1. 2920838565 0. 1896849986 AKT(P) 1. 0609240732 0. 2728756656 1. 1543528836 0. 0448983088 1. 1610765084 0. 0466438512 ERK 1/2 0. 9902553632 0. 1231701937 1. 0395950585 0. 0574600078 0. 9826144613 0. 0440143623 ERK 1/2(P) 0. 8173449079 0. 0528249439 0. 8895647408 0. 0378063366 0. 9018965360 0. 0214080444

Figure 4 B AGE Average total hair blackness Relative value of equal area hair blackness Average Hair Diameter normalized STD KIT+/+ 2 W 11250. 355 0. 47 23936. 926 1 0 KITD 17/+ 2 W 8198. 234 0. 33 24843. 133 1. 0378582 0. 0800143 KITD 17/+ 2 W 4062. 406 0. 3 13541. 353 0. 5657098 0. 0600101 KIT Dup/+ 2 W 7645. 305 0. 39 19603. 346 0. 8189584 0. 0450801 KIT +/+ 14 W 3791. 213 0. 42 9026. 6976 1 0 D 17/+(black) 14 W 1211. 142 0. 3 4037. 14 0. 4472444 0. 015184 KIT D 17/+(white) 14 W 865. 021 0. 28 3089. 3607 0. 3422471 0. 035004 KIT Dup/+ 14 W 3979. 506 0. 34 11704. 429 0. 9348412 0. 0300145 KIT

Figure 5 D AGE Average total hair blackness Average Hair Diameter Relative value of equal area hair blackness normalized STD KIT +/+ 2 W 8534. 312 0. 27 31608. 563 1 0 KIT Dup/D 17(black) 2 W 4233. 749 0. 3 14112. 497 0. 446477 0. 045141 KIT Dup/D 17(white) 2 W 5167. 627 0. 27 19139. 359 0. 6055118 0. 0800047 c-kit+/+ 14 W 10421 0. 41 25417. 073 1 0 c-kit Dup/D 17(white) 14 W 3270 0. 35 9342. 8571 0. 3675819 0. 025117

KIT DCT Melan. A S 100 KIT(P) AKT(P) ERK 1/2(P) Figure 5 E AVR KIT +/+ KIT D 17/DUP 0. 789722 0. 549558 1. 679923 0. 721370 1. 225269 0. 352414 0. 967823 0. 424887 1. 169211 1. 049504 1. 074412 0. 863557 1. 327028 0. 618049 1. 297057 1. 350631 1. 365740 0. 253679 STD KIT +/+ KIT D 17/DUP 0. 034798 0. 035334 0. 082819 0. 090661 0. 131158 0. 065218 0. 162820 0. 107625 0. 077858 0. 061995 0. 122042 0. 110369 0. 125512 0. 086921 0. 084798 0. 147736 0. 153414 0. 053601

Figure 5 G KIT (Mast cell) KIT (Skin) KIT +/+ KIT Dup/D 17 1 0. 2347876 0. 2734650 0. 2098601 0. 1657982 2 0. 2043944 0. 2623252 0. 2127897 0. 1579456 3 0. 2267898 0. 2630674 0. 2069709 0. 1546952 4 0. 2001882 0. 2636676 0. 2113198 0. 1612644 AVERAGE 0. 2165400 0. 2656313 0. 2102351 0. 1599259