Figure 1 What is the relationship between SLE

Figure 1 What is the relationship between SLE and SS? SLE 1. Both SLE and SS very similar genetics and antibodies; Both have Type I IFN signature SS 3. SS is characterized by lymphoid infiltrates in glands and other tissues so lymphocyte aggressive 2. SLE is characterized by Immune Complexes Renal glomeruloneph. Hemolytic anemia Thrombocytopeniaq 4. Homing receptors--- to get lymphocytes to tissues -- Perpetuation of local immune response to produce Antibody to SS-A/SS-B -- Increased risk Lymphoma

However, SS and SLE do have some distinct differences SS is characterized by infiltration of lymphocytes into ocular and salivary glands, so it is more lymphocyte aggressive, and may also includes other systems such as lung (pneumonitis), kidney (interstitial nephritis), neurological (central and peripheral) lymphoproliferative (features) (lymphoma)

Figure 3 Extraglandular manifestations • SLE • Sjogren’s syndrome Skin-hyperglob purpura……. • Lung-interstitial pneumonitis • Renal-interstitial nephritis… • Cardiac-pulmonary hypertension. . • Hematologic--lymphoma…. • Neurologic-peripheral neuropathy • Esophageal-dysphagia and tracheal reflux • Skin-leukocytoclastic vasculitis • Lung-pleural effusions • Renal-glomerulonephritis • Cardiac-pericarditis • Hematologic-ITP, hemolytic anemia • Neuropathy-mononeuritis multiplex •