Fertility Center HOW MANY DOES IT TAKE ACHIEVEMENT

OBJECTIVE • Current data suggests that live birth following transfer of a euploid embryo

MATERIALS & METHODS • Data from 152 patients (202 retrievals, 167 thaws) who underwent

RESULTS Age (y) No. MII Needed to Achieve 1 Euploid Embryo No. MII Needed

CONCLUSIONS • Euploid embryos have a relatively uniform efficiency achievement of a euploid embryo

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Fertility Center HOW MANY DOES IT TAKE? ACHIEVEMENT OF EUPLOID BLASTOCYST (BL) AS THE PRIMARY PREDICTOR OF LIVE BIRTH (LB) IN OOCYTE CRYOPRESERVATION (OC) Shannon De. Vore MD, Sarah Druckenmiller MD, James Grifo MD Ph. D, Mary Elizabeth Fino MD, Kara N. Goldman MD, Nicole Noyes MD

OBJECTIVE • Current data suggests that live birth following transfer of a euploid embryo is independent of age or type of ART treatment • At our center, we have performed >3, 000 independent cycles of both oocyte cryopreservation and trophectoderm biopsy with preimplantation genetic screening (TEBX-PGS) – Recently, we have started using the two technologies together • Aim: to estimate the number of cryopreserved MII oocytes required to achieve live birth at different ages • Design: Retrospective cohort study 2 Fertility Center

MATERIALS & METHODS • Data from 152 patients (202 retrievals, 167 thaws) who underwent autologous oocyte thaws with intended TEBX-PGS No. MII Needed to Achieve 1 Euploid Embryo No. MII Needed to Achieve 1 Live Birth 3 Fertility Center = = No. Thawed MII No. Euploid Embryos No. MII Needed to Achieve 1 Euploid Embryo Live Birth Rate per Euploid Embryo 58%

RESULTS Age (y) No. MII Needed to Achieve 1 Euploid Embryo No. MII Needed to Achieve 1 Live Birth 4 Fertility Center 25 – 34 (n = 23) 35 – 37 (n = 61) 38 – 40 (n = 118) 8 11 13 (385/48) (698/60) (1088/84) 14 20 22 (8/0. 58) (12/0. 58) (13/0. 58)

CONCLUSIONS • Euploid embryos have a relatively uniform efficiency achievement of a euploid embryo after oocyte cryopreservation, thaw and fertilization can help estimate theoretical number of cryopreserved MII oocytes required to achieve 1 live birth • One criticism of oocyte cryopreservation is that it provides women with a false sense of security • Many studies that aim to predict oocyte cryopreservation birth probabilities are limited by lack of autologous oocyte thaw data, and use a subset of the IVF population as a surrogate for oocyte cryopreservation patients, limiting their applicability • Our findings can serve as a counseling tool by providing women with realistic outcomes of oocyte cryopreservation at out center 5 Fertility Center