Federally Funded Research and Development CenterFrederick National Laboratory
Federally Funded Research and Development Center/Frederick National Laboratory for Cancer Research and the Division of Cancer Control and Population Sciences Paige A. Green, Ph. D, MPH October 1, 2015
DCCPS Mission and Vision § Aims to reduce risk, incidence, and deaths from cancer, and enhance quality of life for cancer survivors § Evaluate what has been learned, identify new priorities/strategies, and effectively apply research discoveries to reduce cancer burden § Aspires to be the national model for cancer control science § Cross-cutting areas of emphasis: energy balance, health disparities, patientcentered communication and care coordination, patterns of care 2
DCCPS Organization Behavioral Research Program William Klein Office of the Director Implementation Science Office of Cancer Survivorship Robert Croyle David Chambers Julia Rowland Epidemiology and Genomics Research Program Kathy Helzlsouer Healthcare Delivery Research Program Surveillance Research Program Ann Geiger (Acting) Lynne Penberthy 3
DCCPS Extramural Research Initiatives Supported by FFRDC/FNLCR 1. NCI Network on Biobehavioral Pathways in Cancer 2. Affective Science and Palliative Care Pilot Program 3. Systematic Review to Inform Research and Treatment of Multi-morbidities 4. N of 1 Trial Design for Behavioral Oncology 5. Evidence Synthesis for the Clinically Relevant Variant Consortium 4
The National Cancer Institute Network on Biobehavioral Pathways in Cancer 5
NCI Network on Biobehavioral Pathways in Cancer § Accelerate the discovery of cancer-relevant molecular pathways and networks regulated by social, behavioral, or psychological factors § Support collaborative engagement and meritorious proof of concept/feasibility projects 6
NCI Network on Biobehavioral Pathways in Cancer § Based on a fully collaborative model between the FFRDC contractor, Academia, International Partners, and Consultants § See details of partnerships in the following slides, and note that each collaboration includes the involvement and coordination of the FFRDC contractor 7
Network Projects Supported by FFRDC/FNLCR 1. Novel Small Scale Pilot Projects to Advance the Mission of the NCI Network on Biobehavioral Pathways in Cancer 2. Perioperative Use of Beta-Blocker and COX 2 Inhibitor 3. f. MRI Probe Optimization Study of Social Support 4. Stress and Tumorigenesis in Normal and p 53 Knockout Models 8
Small-Scale Pilot Projects to Advance the Mission of the NCI Network on Biobehavioral Pathways in Cancer 1. Advance knowledge of the molecular and signaling pathways linking psychological, behavioral, or social factors to cancer biology 2. Use that knowledge to seed development of efficacious interventions to improve clinical outcomes Principal Investigator Institution Nathan A. Berger Case Western University Jennifer Knight Medical College of Wisconsin Kelly Madden University of Rochester 9
Perioperative Use of Beta-blocker and Cox 2 Inhibitor § Randomized prospective phase II pilot study to assess the short-term effects of counteracting excess perioperative catecholamine and prostaglandin levels in patients undergoing breast cancer surgery § Institution § Tel Aviv University § Principal Investigator § Shamgar Ben-Eliyahu 10
f. MRI Probe Optimization Study of Social Support § Identify and pilot test f. MRI probe tasks that can be used to capture systematic individual differences in neural activity based on measured experiences of social support § Institution § University of California, Los Angeles § Principal Investigator § Naomi Eisenberger 11
Stress and Tumorigenesis in Normal and p 53 Knockout Models § Test whether use of an established restraint stress paradigm results in an accumulation of DNA damage, as determined by sequencing of DNA and DNA copy number analysis of cells § Institution § Rutgers Robert Wood Johnson Medical School § Principal Investigator § Wenwei Hu 12
Affective Science and Palliative Care Pilot Program 13
Affective Science and Palliative Care Pilot Projects 1. Reanalyze data from palliative care trials to generate hypotheses about mechanisms of effects from a basic affective or decision science perspective 2. Insert measures or methodology into existing or planned palliative care trials to generate hypotheses about mechanisms of effects from a basic affective or decision science perspective Principal Investigator Institution Paul Han Maine Medical Center William Pirl Massachusetts General Hospital 14
Systematic Review to Inform Research and Treatment of Multi-morbidities 15
Systematic Review to Inform Research and Treatment of Multi-morbidities § Review, evaluate and summarize data on the representation of individuals with multiple chronic conditions in randomized controlled trials of behavioral and psychosocial interventions § Institution § Washington University in St. Louis § Principal Investigator § Graham Colditz 16
N of 1 Trial Design in Behavioral Oncology 17
N of 1 Trial Design for Behavioral and Psychological Issues in Cancer Survivorship § N of 1 protocol development for depression symptom management among cancer survivors with multi-morbidity § Institution § Columbia University § Principal Investigator § Karina Davidson 18
Evidence Synthesis for the Clinically Relevant Variant Consortium 19
Clin. Gen – Clinical Genome Resource 20
Evidence Synthesis for the Clinically Relevant Variant Consortium § Refine methodology, produce evidence-based reports for Clin. Gen, and coordinate with the other Clin. Gen groups § Institution § Kaiser Permanente Northwest § Principal Investigator § Katrina Goddard 21
DCCPS Extramural Research Initiatives Supported by FFRDC/FNLCR 1. NCI Network on Biobehavioral Pathways in Cancer 2. Affective Science and Palliative Care Pilot Program 3. Systematic Review to Inform Research and Treatment of Multi-morbidities 4. N of 1 Trial Design for Behavioral Oncology 5. Evidence Synthesis for the Clinically Relevant Variant Consortium 22
www. cancer. gov/espanol
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