Favoritisms and Protection CRANIUM MENINGES BLOOD FLOW BBB
Favoritisms and Protection • • • CRANIUM MENINGES BLOOD FLOW BBB VENTRICULAR SYSTEM
Skull and dura
Dura and blood supply
The cerebroventricular system ventricals and CSF
From Choroid Plexi of Lateral ventricals to 3 rd ventrivcal. . 4 th ventrical to…?
The central canal of the spinal cord
Subarachnoid space of meninges surrounding spinal column. .
Reabsorbed by the “Aracnoid Villi” mostly along the “Superior Saggittal sinus”
“hydrocephaly”
The Blood-Brain Barrier: Astrocytes create tight junctions (barriers) the BBB
The blood brain barrier A physical barrier A system of cellular transport Restricts potentially harmful chemicals from the blood, but allows the entrance of essential nutrients. Lipid soluble molecules, such as ethanol and caffeine are able to penetrate through the barrier relatively easily. In contrast, water soluble molecules are unable cross the barrier without specialized carrier- mediated transport mechanisms. The area postrema and the posterior pituitary area are two regions lacking this barrier.
The BBB • No Dopamine • So L-Dopa • Exception- area postrema
- Slides: 34