Family Rhabditidae Strongyloides stercoralis Dwarf thread worm Strongyloides

Family: Rhabditidae Strongyloides stercoralis (Dwarf thread worm)

Strongyloides stercoralis Dwarf thread worm

Pathological and Clinical effect of Strongyloides stercoralis

Storming

Morphology Parasitic Female Free or parasitic Male Free living Female

• Disease: Strongyloidiasis. • Distribution: • D. H: Man. • Habitat:

Life cycle

Other Modes of infection in strongyloidiasis Auto-infection Swallowing Internal External

Pathogenesis & Clinical picture

Migratory stage (pulmonary phase) Intestinal stage Invasion stage

Invasion stage Dermatitis & itching Larval currens

Pathogenesis & clinical picture of Migratory stage (pulmonary phase) Mechanical trauma of alveolar capillaries haemorrhage inflammatory cell infiltrate in lung tissue & peribronchial tree

Migratory stage (pulmonary phase) Allergic reaction to the larvae bronchial spasm ( fever, dyspnea, dry cough & wheezing) Loeffler’s syndrom V. L. M.

Intestinal stage Light infection symptomless Heavy infection Duodenitis epigastric pain, tenderness anorexia, nausea, vomiting, diarrhoea x constipation. loss of weight, weakness,

In immune- suppressed patient Strongyloides act as an Opportunistic parasite Hyper-infection GIT symptoms Disseminated Strongyloidiasis Massive dehydration Pulmonary haemorrhage Septicaemia Meningitis Paralytic ileus

Clinical picture Diagnosis Indirect Laboratory Blood picture Direct Stool examination Stool culture Serological tests Filariform larvae in CSF, urine & ascetic fluid. Duodenal aspiration

Baermann's apparatus Examination of soil for larvae and free adult worm a e Id

Treatment • Thiabendazole: - 25 mg/kg is given after meals twice daily for 2 -3 days. • Ivermectin: - 200 ug/kg/day for 1 -2 days. • In hyperinfection syndrome, treatment should be continued for 5 -7 days. • NB: -Therapy should be repeated after a week for possibility of autoinfection

Prevention & control: • As in ascariasis • + • Wearing shoes and protective gloves. • In hospitals, the staff must be protected from faeces & sputum of infected patients.