Expert consensus document on arterial stiffness methodological issues

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Expert consensus document on arterial stiffness: methodological issues and clinical applications Согласованное мнение экспертов

Expert consensus document on arterial stiffness: methodological issues and clinical applications Согласованное мнение экспертов ESC по вопросу артериальной ригидности: методические аспекты и клинические применения European Heart Journal 2006 27(21): 2588 -2605

Sample of Examination Result Indicating ASO (1) Triangular wave PWV is low in ASO.

Sample of Examination Result Indicating ASO (1) Triangular wave PWV is low in ASO. Small pulse amplitude

Зависимость СПВ и CAVI от давления Case 1　♀ 70 s (Hypertension, Hyperripidemia, Diabetes, Osteoporosis)

Зависимость СПВ и CAVI от давления Case 1　♀ 70 s (Hypertension, Hyperripidemia, Diabetes, Osteoporosis) Case 2　♂ 60 s (Hypertension, Hyperripidemia, Diabetes) ba. PWV CAVI Systolic Pressure

CAVI and carotid atherosclerosis Area under the ROC curve = 0, 699 Confidence interval

CAVI and carotid atherosclerosis Area under the ROC curve = 0, 699 Confidence interval = 0, 640 to 0, 754 CAVI= 7, 0 * Sens. 67, 4% ; Spec. 65, 1% CAVI= 9. 0 Sens. 10% ; Spec. 98% CAVI may be considered as predictor of the subclinical carotid atherosclerosis

CAVI: age dependent “nornal” values and “standard” “riskdefining thresholds” (cut-off value) K. Shirai, N.

CAVI: age dependent “nornal” values and “standard” “riskdefining thresholds” (cut-off value) K. Shirai, N. Hiruta et al, J Atheroscler Thromb, 2011; 18: 924 -938.

• Circ J. 2011 Feb 25; 75(3): 698 -702. Epub 2010 Dec 24.

• Circ J. 2011 Feb 25; 75(3): 698 -702. Epub 2010 Dec 24. Acute and chronic effects of smoking on arterial stiffness. • Kubozono T, Miyata M, et al. • «Острый» эффект курения

CAVI and Aortic Calcification for Dialysis patient 10 CAVI 9. 5 9 8. 5

CAVI and Aortic Calcification for Dialysis patient 10 CAVI 9. 5 9 8. 5 8 Degree 0 Degree III Degree IV Degree V AACS: aortic arch calcification score（ NDT 2003） （Uchino et al. , Mihama Hospital, Chiba）

CAVI and Metabolic Syndrome 11. 0 age≧５０ years old、Visceral fat area≧ 100 cm 2

CAVI and Metabolic Syndrome 11. 0 age≧５０ years old、Visceral fat area≧ 100 cm 2 CAVI 10. 5 10. 0 9. 5 10. 05± 0. 7 9. 7± 0. 9 9. 4± 0. 7 9. 0 （Average = Number of Risk Factor Items Average of Control 62. 7 years old） １ ２ Hyper TG（≧１５０ｍｇ/ｄｌ）　and/or　low HDL-C（＜４０ｍｇ/ｄｌ） Hypertension （systolic ≧１３０ｍｍHg　and/or　diastolic≧８０ｍｍHg） 　Hyper glycemia（fasting gluscose ≧１１０ｍｇ/ｄｌ）　 ３ Toho Sakura Hospital

CAVI and Atherosclerotic Disease p<0. 001 Case: 0. 9≦ABI<1. 3 Age: 55 -75 n=391

CAVI and Atherosclerotic Disease p<0. 001 Case: 0. 9≦ABI<1. 3 Age: 55 -75 n=391 p<0. 002 p<0. 05 CAVI p<0. 05 mean±SD Dialysis PTCA ECG Abnormal Diabetes+PTCA　　＋ ECG Abnornal Mihama Hospital, Chiba City

Conclusion VS-1500 can measure ABI as well as CAVI 1. ABI: Blockage of vessel

Conclusion VS-1500 can measure ABI as well as CAVI 1. ABI: Blockage of vessel Easy to find PAD patient who possible have coexisting diseases. 2. CAVI: Stiffness of vessel Independent from minutes of BP change, easy testing and stable. The result is clearly related to atherosclerosis disease.