EXPERIENCE THE REVEAL LINQ ADVANTAGE Reveal LINQ Insertable

EXPERIENCE ™ THE REVEAL LINQ ADVANTAGE Reveal LINQ™ Insertable Cardiac Monitoring System with Tru. Rhythm™ Detection

REVEAL™ INSERTABLE CARDIAC MONITOR LEADING INNOVATION FOR MORE THAN 20 YEARS 1998 Reveal 2000 Reveal Plus 2007 Reveal 2009 Reveal 2011 DX XT Full. View Software World’s first ICM 14 -month battery 3 -year battery Added to the Medtronic Care. Link™ Network MR Conditional World’s second ICM 14 -month battery MR Conditional 2014 Reveal LINQ™ World’s smallest ICM Simplified insertion procedure Improved AF detection Simplified reporting and patient management Reveal LINQ™ Insertable Cardiac Monitoring System Improved data viewing and collection Improved noise discrimination Improved AF detection 2017 Tru. Rhythm™ Detection inside the Reveal LINQ ICM 2 3 -year battery AF detection algorithm Cardiac Compass™ diagnostics World’s most accurate ICM New smart filtering & self-learning detection algorithms Improved reporting

THE REVEAL LINQ ADVANTAGE POWERFUL CARDIAC MONITORING Indications for use The Reveal LINQ Insertable Cardiac Monitor (ICM) is an implantable patient-activated and automatically-activated monitoring system that records subcutaneous ECG and is indicated in the following cases: Patients with clinical syndromes or situations at increased risk of cardiac arrhythmias Patients who experience transient symptoms such as dizziness, palpitation, syncope, and chest pain, that may suggest a cardiac arrhythmia The device has not been tested specifically for pediatric use. 3 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE POWERFUL CARDIAC MONITORING ICMs are underutilized ICMs are recommended by clinical guidelines 1, 2 ─ yet significantly underutilized Up to 3 in 4 Patients who met appropriate criteria for ICM implantation did not receive one 3 4 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE AN ADVANCED MONITORING SOLUTION Reveal LINQ ™ ICM My. Care. Link™ Patient Monitor Care. Link™ Network and Reports SOLUTION ENABLERS Insertion Tools Minimally invasive procedure Patient Assistant One-button symptom marking 5 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE REVOLUTIONIZING CARDIAC MONITORING The world’s smallest, most accurate ICM One-third the size of a AAA battery (1. 2 cc) Minimally invasive, simplified insertion procedure 4 Up to a 3 -year longevity for long-term monitoring 5 MR Conditional at 1. 5 and 3. 0 Tesla 6 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE OPTIMIZED LONGEVITY Device longevity that optimizes diagnostic yield Up to 3 years 5 of continuous, long-term cardiac monitoring for infrequent symptoms and ongoing arrhythmia management. 7 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE SIMPLE INSERTION PROCEDURE Best Location: 45 degrees to sternum over 4 th intercostal space, 2 cm from left edge of sternum 97% of physicians found the insertion tool simple and intuitive 4 8 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE SMART ECG DATA STORAGE ECG data storage: 59 minutes total Patient-activated: up to 30 minutes 4 episodes @ 7. 5 minutes each 6. 5 min prior 1 min Patient-activated 3 episodes @ 10 minutes each 9 min prior 1 min Patient-activated 2 episodes @ 15 minutes each 14 min prior Patient Assistant 9 Reveal LINQ™ Insertable Cardiac Monitoring System 1 min Patient-activated

THE REVEAL LINQ ADVANTAGE SMART ECG DATA STORAGE ECG data storage: 59 minutes total Automatically detected: 27 minutes End of episode Pause, Brady, Tachy 30 sec 27 sec Start of episode AT/AF Automatic detection 2 minutes of longest AF episode stored since last interrogation in addition to the 27 minutes of automatically detected episodes. 10 Reveal LINQ™ Insertable Cardiac Monitoring System

THE REVEAL LINQ ADVANTAGE POWERFUL CARDIAC MONITORING Reveal LINQ™ System with Tru. Rhythm™ Detection The world’s smallest, most accurate ICM delivers actionable data to diagnose and treat even the most difficult-to-detect arrhythmias 11 Reveal LINQ™ Insertable Cardiac Monitoring System

UNMATCHED ACCURACY

THE REVEAL LINQ ADVANTAGE UNMATCHED ACCURACY Driving accuracy evolution Dedicated to advancing accuracy with every device generation 13 Reveal LINQ™ Insertable Cardiac Monitoring System

UNMATCHED ACCURACY TRURHYTHM™ DETECTION New intelligence inside Our newest detection algorithms streamline episode review without sacrificing sensitivity Smart filtering NEW second sensing filter analyzes rhythms for possible undersensing in Brady and Pause Self-learning NEW AF algorithm learns and adapts to patients with sinus arrhythmia 14 Reveal LINQ™ Insertable Cardiac Monitoring System

UNMATCHED ACCURACY ATRIAL FIBRILLATION Advanced AF detection* Superior AF detection accuracy that streamlines episode review * In known AF patients. Confirm™ ICM 9 Confirm-AF 9 AF False Positives %† Reveal LINQ ICM 8 Bio. Monitor 2 -AF 10 Reveal LINQ 11 Reveal LINQ with Tru. Rhythm Detection 8 †% of False Positives = (1 -Episode PPV). Episode PPV may vary (gross, patient average). 15 Reveal LINQ™ Insertable Cardiac Monitoring System

UNMATCHED ACCURACY ACTIONABLE REPORTING Cardiac Compass™ Report Daily AF Burden Ventricular Rate During AF Day/Night HR Patient Activity Heart Rate Variability All patient and clinical data are fictitious and for demonstration purposes only. 16 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE

THE REVEAL LINQ ADVANTAGE SUPERIOR EVIDENCE MOST STUDIED Evidence portfolio that includes 500+ published clinical articles and abstracts 12 MOST VALIDATED Clinical validation across Cryptogenic Stroke, Syncope, and Atrial Fibrillation patients 6, 11, 13, 14 MOST UTILIZED Data leveraged by clinical societies to develop treatment guidelines across conditions 1, 2 18 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE CRYPTOGENIC STROKE Each year, at least 200, 000 cryptogenic strokes occur in the United States 15 Cryptogenic stroke accounts for approximately 1/3 of ischemic strokes in the majority of modern stroke registries 16 -21 19 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE CRYPTOGENIC STROKE AF DETECTION AND TREATMENT MATTERS 5 X 2 X % 67 increase in ischemic stroke risk for AF patients 22 more likely for AF-related ischemic stroke to be fatal than non-AF stroke 23 decrease in AF stroke risk with oral anticoagulants 24 20 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE CRYPTOGENIC STROKE CRYSTAL AF Study 6 The CRYSTAL-AF Study found that continuous monitoring with Reveal ICM is superior to standard medical care for the detection of AF in cryptogenic stroke patients 84 DAYS median time to AF detection in cryptogenic stroke patients 6 % 88 of patients who had AF would have been missed if only monitored for 30 days 6 21 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE CRYPTOGENIC STROKE 2016 ESC guidelines for the management of AF Long-term insertable cardiac monitoring recommended for cryptogenic stroke patients to document silent AF 1 22 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE SYNCOPE AVERAGES 740, 000 ER VISITS PER YEAR*25 237, 000 HOSPITALIZATIONS 25 26 *Data obtained from National Hospital Ambulatory Medical Care Survey between 1992 to 2000. SYNCOPE WITH A CARDIAC CAUSE INCREASES MORTALITY RATES 23 Reveal LINQ™ Insertable Cardiac Monitoring System HALF OF PATIENTS ADMITTED TO THE HOSPITAL LEAVE WITHOUT A DIAGNOSIS 2 X % >10 increased risk of death 27 mortality rate at six months 27

SUPERIOR EVIDENCE SYNCOPE 3 Patients want answers specialists visited on average 13 Patients endure ongoing diagnostic testing and still come away with no answers 13 Physician specialties consulted 13 Diagnostic tests performed 13 13 inconclusive tests 13 1 in 4 undergo more than 20 tests 13 24 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE SYNCOPE PICTURE Study 13 570 patients enrolled 100% OF THESE PATIENTS RECEIVED A DIFFERENTIAL DIAGNOSIS 25 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE SYNCOPE 2017 ACC/AHA/HRS guidelines for the management of syncope 2 Insertable cardiac monitoring recommended for syncope patients based on frequency and nature of events 26 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE ATRIAL FIBRILLATION 29 28 SYMPTOMS ARE NOT A RELIABLE INDICATIOR OF AF 27 % ~90 th 1/5 STROKE % 61 of AF episodes may be asymptomatic 30 of patient symptoms thought to be AF were actually due to AF 30 is the first symptom for ~20% of patients who have an AF-related stroke 23 of patients who had both AF and a stroke did not know they had AF before their stroke 31 Reveal LINQ™ Insertable Cardiac Monitoring System

SUPERIOR EVIDENCE ATRIAL FIBRILLATION REVEAL AF Study 14 AF detection increases over time for patients at high risk for AF and stroke. % 40 AF detection rate at 30 months 14 % 84. 5 of patients with AF would have been missed if only monitored for 30 days 14 28 Reveal LINQ™ Insertable Cardiac Monitoring System

SIMPLIFIED MONITORING

THE REVEAL LINQ ADVANTAGE SIMPLIFIED MONITORING APP-BASED INSERTION WORKFLOW MORE EFFICIENT DATA MANAGEMENT A VIRTUAL EXTENSION OF YOUR CLINICAL TEAM Reveal LINQ Mobile Manager Enhanced Care. Link™ Network Reveal LINQSM Monitoring Service 30 Reveal LINQ™ Insertable Cardiac Monitoring System

SIMPLIFIED MONITORING REVEAL LINQ MOBILE MANAGER Powerfully simple device management Manage device registration, activation, Care. Link™ pre-enrollment and patient education – right from your tablet 31 Reveal LINQ™ Insertable Cardiac Monitoring System

SIMPLIFIED MONITORING THE CARELINK NETWORK More efficient data management Quick Look™ update provides new timesaving for clinicians who manage Reveal LINQ patients Fewer Downloads Fewer downloads mean less time waiting for the Care. Link Network to access the information you need Fewer Clicks 32 Transmission Details opens the Quick Look view Assess and adjudicate episodes right from the Quick Look page -- no need to navigate between episodes Reveal LINQ™ Insertable Cardiac Monitoring System Previous Workflow NEW Workflow

SIMPLIFIED MONITORING THE CARELINK NETWORK Clinically actionable reports Simple and clear reporting that provides the information you need to take action Event Reports Summary Reports Delivered based on clinician-ordered criteria Delivered every 30 days Clinical and patient data are fictitious and for demonstration purposes only. 33 Reveal LINQ™ Insertable Cardiac Monitoring System Full Report Delivered when you request manual transmission

SIMPLIFIED MONITORING REVEAL LINQ MONITORING SERVICE Support to optimize your time A virtual extension of your clinical team, helping you streamline patient management and cardiac data review for patients with a Reveal LINQ™ ICM. * * Patients must be covered by insurance providers who are on contract with the service. Patient management and communication ensures data transmission 34 Reveal LINQ™ Insertable Cardiac Monitoring System Cardiac data review by certified technicians identifies the most clinically relevant data Clinically actionable reporting summarizes what you want to know to inform decisions

THE REVEAL LINQ ADVANTAGE SYNCOPE PATIENT IMPACT William’s story Reveal LINQ ICM used to discover Atrioventricular Nodal Reentrant Tachycardia The first time William fainted was just after he stood up to get a second cup of coffee. He was unconscious for 30 seconds while his wife feared he was dead. Another time while out for dinner, without warning his head fell forward and he lost consciousness. Over the years, William experienced an ambulance trip, multiple visits to the hospital, and appointments with various physician specialties. Multiple tests showed nothing. Years went by without incident until he was on vacation in Paris. As he walked along a cobblestone street with his family, William collapsed. His face slammed into the cobblestone curb causing serious injury. Back in the US, his doctor recommended the Reveal LINQ ICM. The device was inserted in February, 2016. The following August, an episode of nonsustained SVT was detected while he slept. Today, following a successful ablation procedure, William is back to enjoying life. He works out multiple times a week and enjoys traveling with his family, playing basketball, tennis, and golf. 35 Reveal LINQ™ Insertable Cardiac Monitoring System This story reflects one person’s experience. Not every person will receive the same results.

THE REVEAL LINQ ADVANTAGE CRYPTOGENIC STROKE PATIENT IMPACT Scott’s story Reveal ICM used to discover AF in 22 -year-old stroke patient On his way to a soccer game, 22 -year-old Scott suddenly began wobbling. His head started throbbing. What he thought was dehydration turned out to be much worse. The college student had suffered a stroke. Surgeons removed a blood clot in his brain, but a looming question remained: What caused the stroke in this seemingly healthy young man? Scott’s doctors suspected it was the result of atrial fibrillation (AF). So Scott’s doctors turned to the Reveal LINQ ICM, which, within a few months, confirmed he had AF. The diagnosis not only gave Scott’s doctors the information they needed to prescribe strokepreventive blood thinners; it gave Scott the peace of mind to live life fully again. 36 Reveal LINQ™ Insertable Cardiac Monitoring System FPO This story reflects one person’s experience. Not every person will receive the same results.

THE REVEAL LINQ ADVANTAGE ATRIAL FIBRILLATION PATIENT IMPACT Debbie’s story Reveal ICM finds AF and informs treatment plan When Debbie started experiencing an uncomfortable heart fluttering, she tried to ignore it. When the episodes became more frequent, she could no longer deny something was wrong. That’s when she made an appointment with a cardiologist. Debbie’s doctor suggested an insertable cardiac monitor to determine the cause of her episodes. The Reveal ICM discovered that the upper chambers of Debbie’s heart were beating very fast and irregularly. She was referred to an EP, who used the Reveal ICM data to guide the development of a treatment plan. Eventually, Debbie regained her old energy and enthusiasm. “I was so excited that it captured an abnormal heart rhythm. It wasn’t in my head after all, ” Debbie said. 37 Reveal LINQ™ Insertable Cardiac Monitoring System This story reflects one person’s experience. Not every person will receive the same results.

REFERENCES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 38 Kirchhof P, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016; 37: 2893 -2962 Shen WK, et al. 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope. J Am Coll Cardiol. 2017. DOI: 10. 1016/j. jacc. 2017. 03. 003. Vitale E, Ungar A, Maggi R, et al. Discrepancy between clinical practice and standardized indications for an implantable loop recorder in patients with unexplained syncope. Europace. October 2010; 12(10): 1475 -1479. Sanna T, Diener HC, Passman RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. June 26, 2014; 370(26): 2478 -2486. Reveal LINQ Usability Study. Medtronic data on file. 2013. Reference the Reveal LINQ ICM Clinician Manual for usage parameters. Sanna T, Diener HC, Passman RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. June 26, 2014; 370(26): 2478 -2486. Furukawa T, Maggi R, Bertolone C, Fontana D, Brignole M. Additional diagnostic value of very prolonged observation by implantable loop recorder in patients with unexplained syncope. J Cardiovasc Electrophysiol. January 2012; 23(1): 67 -71. Tru. Rhythm Detection Algorithms. Medtronic data on file. 2017. Nölker G, Mayer J, Boldt LH, et al. Performance of an Implantable Cardiac Monitor to Detect Atrial Fibrillation: Results of the DETECT AF Study. J Cardiovasc Electrophysiol. December 2016; 27(12): 1403 -1410. Biotronik Bio. Monitor 2 Clinical Manual. 2016. Sanders P, Pürerfellner H, Pokushalov E, et al. Performance of a new atrial fibrillation detection algorithm in a miniaturized ICM: Results from the Reveal LINQ Usability Study. Heart Rhythm. July 2016; 13(7): 1425 -1430. Medtronic Reveal Publications. Medtronic data on file. 2016. Edvardsson N, Frykman V, van Mechelen R, et al. Use of an implantable loop recorder to increase the diagnostic yield in unexplained syncope: results from the PICTURE registry. Europace. February 2011; 13(2): 262 -269. Reiffel JA, Verma A, Kowey PR, et al. High Incidence of Previously Unknown (“Silent”) Atrial Fibrillation in Patients at High Risk for Atrial Fibrillation and Stroke: Primary Results from the REVEAL AF Study. Abstract presented at Heart Rhythm Society Annual Scientific Sessions. 2017. American Heart Association. Heart Disease and Stroke Statistics, 2015 Update. Available at: http: //www. heart. org/HEARTORG/General/Heartand-Stroke-Association-Statistics_UCM_319064_Sub. Home. Page. jsp. Accessed April 12, 2015. Sacco RL, Ellenberg JH, Mohr JP, et al. Infarcts of undetermined cause: the NINCDS Stroke Data Bank. Ann Neurol. April 1989; 25(4): 382 -390. Petty GW, Brown RD Jr, Whisnant JP, Sicks JD, O’Fallon WM, Wiebers DO. Ischemic stroke subtypes: a population-based study of incidence and risk factors. Stroke. December 1999; 30(12): 2513 -2516. Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. December 1, 2001; 32(12): 2735 -2740. Schulz UG, Rothwell PM. Differences in vascular risk factors between etiological subtypes of ischemic stroke: importance of population-based studies. Stroke. August 2003; 34(8): 2050 -2059. Reveal LINQ™ Insertable Cardiac Monitoring System

REFERENCES 20. Schneider AT, Kissela B, Woo D, et al. Ischemic stroke subtypes: a population-based study of incidence rates among blacks and whites. Stroke. July 2004; 35(7): 1552 -1556. 21. Lee BI, Nam HS, Heo JH, Kim DI, Yonsei Stroke Team. Yonsei Stroke Registry. Analysis of 1, 000 patients with acute cerebral infarctions. Cerebrovasc Dis. 2001; 12(3): 145 -151. 22. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med. September 1987; 147(9): 1561 -1564. 23. Lin HJ, Kelly-Hayes M, Beiser AS, et al. Stroke Severity in Atrial Fibrillation: The Framingham Study. Stroke. 1996; 27: 1760 -1764 24. Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation. August 1991; 84(2): 527 -539. 25. Sun BC, Emond JA, Camargo CA Jr. Inconsistent electrocardiographic testing for syncope in United States emergency departments. Am J Cardiol. May 15, 2004; 93(10): 1306 -1308. 26. Mendu ML, Mc. Avay G, Lampert R, Stoehr J, Tinetti ME. Yield of diagnostic tests in evaluating syncopal episodes in older patients. Arch Intern Med. July 27, 2009; 169(14): 1299 -1305. 27. Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. September 19, 2002; 347(12): 878 -885. 28. World Heart Federation statistics. http: //www. world-heart-federation. org/cardiovascular-health/stroke/. 29. Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics — 2017 Update. A Report From the American Heart Association. Circulation. March 7, 2017; 135(10): e 146 -e 603. 30. Strickberger, SA, Ip J, Saksena S, et al. Relationship between atrial tachyarrhythmias and symptoms. Heart Rhythm. February 2005; 2(2): 125131. Frankel D, Parker S, Rosenfeld L, et al. HRS/NSA 2014 survey of atrial fibrillation and stroke: Gaps in knowledge and perspective, opportunities for improvement. Heart Rhythm. August 2015; 12(8): e 105 -e 113. 39 Reveal LINQ™ Insertable Cardiac Monitoring System

INDICATIONS, SAFETY, AND WARNINGS If you are located in the United States, please refer to the brief statement below to review applicable indications, safety, and warning information. See the device manual for detailed information regarding the implant procedure, indications, contraindications, warnings, precautions, and potential complications/adverse events. For further information, please call Medtronic at 763 -514 -4000 and/or consult the Medtronic website at medtronic. com. If you are located outside the United States, see the device manual for detailed information regarding the implant procedure, indications, contraindications, warnings, precautions, and potential adverse events. For further information, contact your local Medtronic representative and/or consult the Medtronic website at medtronic. com. Consult instructions for use at this website. Manuals can be viewed using a current version of any major Internet browser. For best results, use Adobe Acrobat Reader® with the browser. Important Reminder: This information is intended only for users in markets where Medtronic products and therapies are approved or available for use as indicated within the respective product manuals. Content on specific Medtronic products and therapies is not intended for users in markets that do not have authorization for use. The Medtronic My. Care. Link Patient Monitor and the Medtronic Care. Link Network are indicated for use in the transfer of patient data from Medtronic implantable cardiac devices. These products are not a substitute for appropriate medical attention in the event of an emergency. Data availability and alert notifications are subject to Internet connectivity and access, and service availability. The My. Care. Link Patient Monitor must be on and in range of the device. Alert notifications are not intended to be used as the sole basis for making decisions about patient medical care. Reveal LINQ™ Insertable Cardiac Monitor, Reveal LINQ™ Mobile Manager System and Patient Assistant Indications: The Reveal LINQ insertable cardiac monitor (ICM) is an implantable patient-activated and automatically-activated monitoring system that records subcutaneous ECG and is indicated in the following cases: Patients with clinical syndromes or situations at increased risk of cardiac arrhythmias Patients who experience transient symptoms such as dizziness, palpitation, syncope, and chest pain, that may suggest a cardiac arrhythmia The device has not been tested specifically for pediatric use. Reveal LINQ Mobile Manager System The Reveal LINQ Mobile Manager app is intended for programming and interrogating the Reveal LINQ ICM LNQ 11. The Medtronic 24965 patient connector is a portable electronic device using low frequency inductive telemetry to communicate with the Reveal LINQ ICM. The patient connector uses Bluetooth® technology to transmit implantable heart device data to the Reveal LINQ Mobile Manager app for further processing. The patient connector is intended to be used by healthcare personnel only in a clinical or hospital environment. 40 Reveal LINQ™ Insertable Cardiac Monitoring System

INDICATIONS, SAFETY, AND WARNINGS Patient Assistant The Patient Assistant is intended for unsupervised patient use away from a hospital or clinic. The Patient Assistant activates the data management feature in the Reveal™ insertable cardiac monitor to initiate recording of cardiac event data in the implanted device memory. Contraindications: There are no known contraindications for the implant of the Reveal LINQ ICM or for the Reveal LINQ Mobile Manager system. However, the patient’s particular medical condition may dictate whether or not a subcutaneous, chronically implanted device can be tolerated. Reveal LINQ Insertable Cardiac Monitor Warnings/Precautions Patients with the Reveal LINQ ICM should avoid sources of diathermy, high sources of radiation, electrosurgical cautery, external defibrillation, lithotripsy, therapeutic ultrasound and radiofrequency ablation to avoid electrical reset of the device, and/or inappropriate sensing as described in the Medical procedure and EMI precautions manual. MRI scans should be performed only in a specified MR environment under specified conditions as described in the Reveal LINQ MRI Technical Manual. Reveal LINQ Mobile Manager System Before inserting the Reveal LINQ ICM, verify that the patient connector and mobile device are fully charged. The patient connector and mobile device may run out of power during the insertion procedure if they are not fully charged. You will not be able to program or interrogate the patient’s Reveal LINQ ICM until the patient connector and the mobile device have power. Only use the patient connector to communicate with the intended implanted device. Do not use the patient connector to communicate with other implanted devices. Using the patient connector to communicate with other implanted devices can interfere with those devices, potentially affecting the other implanted device’s functionality or therapy delivery. Use of wireless devices — The patient connector incorporates radiofrequency (RF) communications components which may affect other devices and equipment in the medical environment. The use of wireless devices in the medical environment must be evaluated and authorized by the responsible organization. RF interference may affect device performance. Electromagnetic Compliance (EMC) testing shows that the patient connector provides reasonable protection against harmful interference and provides EMC immunity in a typical medical installation. The use of wireless devices in the medical environment must be evaluated and authorized by the responsible organization. However, there is no guarantee that interference will not occur in a particular installation. If the patient connector does cause harmful interference to other devices or is negatively impacted by other devices, correct the interference by one or more of the following measures: reorient or relocate the patient connector and other devices; increase the separation between the patient connector and other devices by at least two meters (approximately 6 feet); and/or turn off any interfering equipment. Radiofrequency (RF) interference — Portable and mobile RF communications equipment can interfere with the operation of the patient connector. There is no guarantee that it will not receive interference or that any particular transmission from this system will be free from interference. To avoid interference, do not use the patient connector and mobile device within 2 m (6 feet) of other wireless communications equipment. Using the patient connector near these devices could interfere with communication between the Reveal LINQ ICM and the patient connector. 41 Reveal LINQ™ Insertable Cardiac Monitoring System

INDICATIONS, SAFETY, AND WARNINGS Security — Maintain adequate physical security of the patient connector to prevent unauthorized use that could lead to harm to patients. Bluetooth communication in the patient connector is encrypted for security. Medtronic inductive telemetry uses short-range communication to protect patient information. If the patient connector should fail, there is no risk of patient harm. Environmental precautions — To ensure safe and effective operation, use the device with care to avoid damage to the patient connector from environmental factors that may impair its function. Care is exercised in design and manufacturing to minimize damage to devices under normal use. However, electronic devices are susceptible to many environmental stresses. Specifically, the patient connector may be affected by electrostatic discharge (ESD). In an environment likely to cause ESD, such as a carpeted floor, discharge any charge collected on your body before touching the device. Patient Assistant Operation of the Patient Assistant near sources of electromagnetic interference, such as cellular phones, computer monitors, etc. , may adversely affect the performance of this device. Potential Complications: Potential complications of the Reveal LINQ device include, but are not limited to, device rejection phenomena (including local tissue reaction), device migration, infection, and erosion through the skin. Medtronic My. Care. Link™ Patient Monitor, Medtronic Care. Link™ Network and Care. Link™ Mobile Application Intended Use: The Medtronic My. Care. Link patient monitor and Care. Link network are indicated for use in the transfer of patient data from some Medtronic implantable cardiac devices based on physician instructions and as described in the product manual. The Care. Link mobile application is intended to provide current Care. Link network customers access to Care. Link network data via a mobile device for their convenience. The Care. Link mobile application is not replacing the full workstation, but can be used to review patient data when a physician does not have access to a workstation. These products are not a substitute for appropriate medical attention in the event of an emergency and should only be used as directed by a physician. Care. Link network availability and mobile device accessibility may be unavailable at times due to maintenance or updates, or due to coverage being unavailable in your area. Mobile device access to the Internet is required and subject to coverage availability. Standard text message rates apply. Contraindications: There are no known contraindications. Warnings and Precautions: The My. Care. Link patient monitor must only be used for interrogating compatible Medtronic implantable devices. See the device manuals for detailed information regarding the implant procedure, indications, contraindications, warnings, precautions, and potential complications/adverse events. For further information, please call Medtronic at 1 -800 -328 -2518 and/or consult the Medtronic website at medtronic. com. Caution: Federal law (USA) restricts these devices to sale by or on the order of a physician. 42 Reveal LINQ™ Insertable Cardiac Monitoring System

Medtronic and the Medtronic logo are trademarks of Medtronic. ™ * Third party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company. Medtronic 710 Medtronic Parkway Minneapolis, MN 55432 -5604 USA Tel: 763. 514. 4000 Fax: 763. 514. 4879 medtronic. com 43 Toll-free: 1. 800. 328. 2518 (24 -hour technical support for physicians and medical professionals) UC 201700319 b EN © 2017 Medtronic. Minneapolis, MN. All Rights Reserved. 07/2017 Reveal LINQ™ Insertable Cardiac Monitoring System