Exam 2 Review Kent Lin and Mc Kenna

Exam 2 Review Kent Lin and Mc. Kenna Wilhelm

Lecture 9/23 Lecture Overview • History • Lipid components and asymmetry • Bioactive lipid metabolites • Membrane proteins • Amino acids in the membrane • Lipid modifications • Subdomains (lipid rafts)

Lecture 9/25 Lecture Overview • Selective permeability • Osmolarity and osmotic pressure • Ionic gradients • Electrical properties: resistance and capacitance • Electrochemical equilibrium • Environmental change • GHK equation • Intro to simulation

Nice little website: https: //www. medicine. mcgill. ca/physio/vlab/rmp/theory_RMP_n. htm

In General: Eion = (60 m. V / z) * log ([ion]out / [ion]in) @ 30°

Lecture 9/30 Lecture Overview • Review of cellular electricity • Recording cellular electricity • Theories about channel selectivity • Channel structures and selectivity • Voltage-dependent gating • Channel-lipid interactions • Ligand-gated channels • Aquaporins and connexins

The derivative of a function y = f(x) of a variable x is a measure of the rate at which the value y of the function changes with respect to the change of the variable x. It is called the derivative of f with respect to x.

Probability in respect to open or closed Time constant for when the system reaches equilibrium if starts out closed with consideration to a and b

Hyperinsulinemia in absence of KATP channel activity ? b-cell response to a fall in blood glucose in absence of KATP Glucose Glut 2 Glucose Blood Insulin ATP + Ca 2+ KATP ADP KATP channel is not activated, insulin secretion is maintained, and blood glucose drops further…?

Diabetes if KATP channels become overactive? If KATP channel is not inhibited, insulin secretion remains turned off? Glucose Glut 2 Glucose Blood Insulin 2+ Ca KATP ADP

• Membrane flux what is it governed by • How types of transporter affects flux of solutes • How transport is determined by membrane potential