Evolution of biomedical innovation potential 1970 s 1975

Evolution of biomedical innovation potential … 1970 s 1975 1980 1985 From … 1990 1992 1994 1995 Functional Genetics 1996 1997 1998 … to … 1999 2000 2001 2002 2004 2006 Functional Genomics

An Integrative Approach for Discovery of Gene Function in Immunological Disease New Animal Models Functional Genetics Molecular & Cellular pathways Sensitized ENU mutagenesis Gene & pathway validation in animal models Gene & pathway prediction Cross platform validation (GO, QTLs, human) Expression profiling

New knowledge & Innovation Business Research €€€€

The Greek perspective; Can we succeed in a new knowledge-driven economy? • Excellent Greek scientists exist all over the world (including Greece) • EU membership • Small country providing advantages on focus and synergies

… on research • Biomedical Research highly fragmented • National Policies and Instruments still pending • Industrial collaborations without impact • Nuclei of excellence still exist • Reforms and investment necessary

A few Recommendations for an Integrated Support of the Greek Research Environment • Reform National Research Funding System (involve stakeholders) • Meritocracy and accountability – follow international standards • Integrated design based on excellence and first-rate scientists • Foster creative research careers of outstanding young researchers • Develop large infrastructures / projects needed for innovation • Invest more on Research Institutes (rather than Universities) • Incubate technology transfer structures with free academic research

… on commercialization • Lack of entepreneurship and business skills • Little help for start-ups (IPR management, financing, management) • Limited access to knowledge portfolios • Need for a common vision between R&B • Reforms and investment necessary

A few Recommendations for an Integrated Support of the Greek Innovative Business Environment • Business start-up incentives and assistance or mentoring • IPR assistance and management for Biotech • High standards incubating facilities / clusters • Financing and further organizational support • Support for further R&D in start-ups • Integrated National Innovation System

BIOMEDICAL SCIENCES RESEARCH CENTRE ‘ALEXANDER FLEMING’ (Vari – Greece) A European Centre of Excellence in Functional Genomics Research Institutes Mouse Clinic Technology Incubator