Eukaryotic initiation factor 2 phosphorylation is required for

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Eukaryotic initiation factor 2α phosphorylation is required for B-cell maturation and function in mice

Eukaryotic initiation factor 2α phosphorylation is required for B-cell maturation and function in mice by Nina Mielke, Rolf Schwarzer, Cornelis F. Calkhoven, Randal J. Kaufman, Bernd Dörken, Achim Leutz, and Franziska Jundt haematol Volume 96(9): 1261 -1268 August 31, 2011 © 2011 by Ferrata Storti Foundation

Reconstitution of fetal liver chimeras. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268

Reconstitution of fetal liver chimeras. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation

Differential blood counts. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011

Differential blood counts. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation

Decrease of CD 19+ B cells in the peripheral blood of transplanted mice. Nina

Decrease of CD 19+ B cells in the peripheral blood of transplanted mice. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation

Diminished mature B cells in the bone marrow of mice transplanted with e. IF

Diminished mature B cells in the bone marrow of mice transplanted with e. IF 2α-AA (n=13) mutant fetal liver cells as compared to WT controls (e. IF 2α-SS, n=17). Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation

Follicular B cells are reduced in mice transplanted with e. IF 2α-AA mutant fetal

Follicular B cells are reduced in mice transplanted with e. IF 2α-AA mutant fetal liver cells. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation

Impaired proliferative responses of splenic B cells of mice transplanted with e. IF 2α-AA

Impaired proliferative responses of splenic B cells of mice transplanted with e. IF 2α-AA mutant fetal liver cells. Nina Mielke et al. Haematologica 2011; 96: 1261 -1268 © 2011 by Ferrata Storti Foundation