Essential Training Package for HPV Vaccine Introduction Module

Essential Training Package for HPV Vaccine Introduction Module 2 HPV vaccine attributes and storage conditions Cervarix. TM

Learning objectives l At the end of the module, you will have learned to: - Describe HPV vaccine characteristics (Cervarix. TM) Discuss the presentation of HPV vaccine Apply vaccine cold chain requirements Describe proper handling of 2 -dose vial Cervarix. TM Vaccine l Duration – 25’ 2 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Key issues 1 What is HPV vaccine, Cervarix. TM, presentation? 2 How effective is the vaccine? 3 How safe is the vaccine? 4 At which temperature should the vaccine be stored? Where in the refrigerator should HPV 5 vaccines be stored? What is the proper handling of 2 - 6 dose vial Cervarix. TM vaccine? 3 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

What is the presentation of Cervarix. TM? l Cervarix. TM is available in a liquid formulation: Ø as single dose vial and 2 -dose vial, both preservative-free l Single dose vial has 0. 5 m. L suspension l 2 -dose vial has 1. 0 m. L suspension l Each vial contains a Vaccine Vial Monitor (VVM) l Vaccine vials are available in pack sizes of 1, 10, and 100 4 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Is Cervarix. TM effective? l Cervarix. TM is a bivalent vaccine to prevent: – Infection due to HPV types 16 & 18 that cause the majority of cervical cancers l High efficacy of Cervarix. TM against persistent infection with HPV types has been demonstrated in females l There is no evidence of waning immunity 5 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Is Cervarix. TM safe? l Cervarix. TM is well-tolerated with no major safety concerns l Injection site reactions such as redness, pain and swelling can occur l Mild adverse events include fever, dizziness and nausea l Syncope can occur after any medical procedure and is not uncommon in adolescents following receipt of a vaccine. l It is recommended that adolescents be seated during HPV vaccine administration and observed for 15 minutes afterwards 6 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

HPV vaccine storage conditions l HPV vaccines should be stored between +2 o. C and +8 o. C l HPV vaccine is freeze sensitive l HPV vaccine is light sensitive 7 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Temperature sensitivity of vaccines Heat sensitivity Most sensitive OPV MMR Measles Rotavirus Pentavalent Pneumo PS-PCV BCG Vaccines to the left of the line are not damaged by freezing Least sensitive Freeze dried Liquid, no adjuvant Liquid, with alum adjuvant Hep. B Freeze sensitivity 8 | HPV vaccine attributes and storage conditions, | September 2020 HPV Vaccine formulation Module 2 Cervarix. TM Most sensitive

Where to place HPV vaccine in the refrigerator? 9 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Which vaccine vials should be stored in front? l Vaccine vials with early expiration dates and vials with VVM that has started to change color should be kept in front to be used first Further expiry date in back Closer expiry date in front 10 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Cold boxes and vaccine carriers 11 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Proper handling of 2 -dose vial of Cervarix. TM? 12 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

Key messages l Cervarix. TM vaccine is safe and effective l Cervarix. TM is available as a single dose vial (0. 5 m. L) and a 2 -dose vial (1. 0 m. L) in a liquid, preservative-free formulation with VVM l HPV vaccine is freeze sensitive and light sensitive – HPV vaccines must be stored at +2 o. C to +8 o. C – HPV vaccines should be stored in their original package l When using icepacks in cold boxes and vaccine carriers, ensure that icepacks are properly conditioned to reduce the risk of vaccine freezing l Discard any open vials with unused Cervarix. TM dose at the end of the immunization session or 6 hours after opening, whichever comes first 13 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

End of module Thank you for your attention! 14 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM

References l HPV vaccine introduction into national immunization programmes: Information for programme managers and health workers. WHO 2014 l Cervarix. TM package inserts. Glaxo. Smith. Kline 2009 15 | HPV vaccine attributes and storage conditions, | September 2020 Module 2 Cervarix. TM