Essential Training Package for HPV Vaccine Introduction Module

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Essential Training Package for HPV Vaccine Introduction Module 2 HPV vaccine attributes and storage

Essential Training Package for HPV Vaccine Introduction Module 2 HPV vaccine attributes and storage conditions Gardasil. TM

Learning objectives l At the end of the module, you will have learned to:

Learning objectives l At the end of the module, you will have learned to: - Describe HPV vaccine characteristics (Gardasil. TM) - Discuss the presentation of HPV vaccine - Apply vaccine cold chain requirements l Duration – 25’ 2 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Key issues 1 What is HPV vaccine, Gardasil. TM, presentation? 2 How effective is

Key issues 1 What is HPV vaccine, Gardasil. TM, presentation? 2 How effective is the vaccine? 3 How safe is the vaccine? 4 At which temperature should the vaccine be stored? 5 Where in the refrigerator should HPV vaccines be stored? 3 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

What is the presentation of Gardasil. TM? l Gardasil. TM (or Silgard. TM) is

What is the presentation of Gardasil. TM? l Gardasil. TM (or Silgard. TM) is available in a liquid formulation: Ø as a single dose vial Ø intramuscular injection l 1 vial has 0. 5 m. L suspension l Each vial contains a Vaccine Vial Monitor (VVM) l Vaccine vials are available in pack sizes of 1, 10, and 100 4 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Is Gardasil. TM effective? l Gardasil. TM is a quadrivalent vaccine to prevent from:

Is Gardasil. TM effective? l Gardasil. TM is a quadrivalent vaccine to prevent from: – Infection due to HPV types 16 & 18 that cause the majority of cervical cancers – Infection due to HPV types 6 & 11 that are responsible for genital warts l High efficacy of Gardasil. TM against persistent infection with HPV types has been demonstrated in females l There is no evidence of waning immunity 5 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Is Gardasil. TM safe? l Gardasil. TM is well-tolerated with no major safety concerns

Is Gardasil. TM safe? l Gardasil. TM is well-tolerated with no major safety concerns l Injection site reactions such as redness, pain and swelling can occur l Mild adverse events include fever, dizziness and nausea l Syncope can occur after any medical procedure and is not uncommon in adolescents following receipt of a vaccine. l It is recommended that adolescents be seated during HPV vaccine administration and observed for 15 minutes afterwards 6 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

HPV vaccine storage conditions l HPV vaccines should be stored between +2 o. C

HPV vaccine storage conditions l HPV vaccines should be stored between +2 o. C and +8 o. C l HPV vaccine is freeze sensitive l HPV vaccine is light sensitive 7 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Temperature sensitivity of vaccines Heat sensitivity Most sensitive OPV MMR Measles Rotavirus Pentavalent Pneumo

Temperature sensitivity of vaccines Heat sensitivity Most sensitive OPV MMR Measles Rotavirus Pentavalent Pneumo PS-PCV BCG Vaccines to the left of the line are not damaged by freezing Least sensitive Freeze dried Liquid, no adjuvant Liquid, with alum adjuvant Hep. B Freeze sensitivity 8 | HPV vaccine attributes and storage conditions, | March 2021 HPV Vaccine formulation Module 2 Gardasil. TM Most sensitive

Where to place HPV vaccine in the refrigerator? 9 | HPV vaccine attributes and

Where to place HPV vaccine in the refrigerator? 9 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Which vaccine vials should be stored in front? l Vaccine vials with early expiration

Which vaccine vials should be stored in front? l Vaccine vials with early expiration dates and vials with VVM that has started to change color should be kept in front to be used first Further expiry date in back Closer expiry date in front 10 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Cold boxes and vaccine carriers 11 | HPV vaccine attributes and storage conditions, |

Cold boxes and vaccine carriers 11 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

Key messages l Gardasil. TM vaccine is safe and effective l Gardasil. TM is

Key messages l Gardasil. TM vaccine is safe and effective l Gardasil. TM is available as a single dose vial (0. 5 m. L) in a liquid formulation with VVM l HPV vaccine is freeze sensitive and light sensitive – HPV vaccine must be stored at +2 o. C to +8 o. C – HPV vaccine should be stored in their original package l When using icepacks in cold boxes and vaccine carriers, they should be conditioned to reduce the risk of vaccine freezing 12 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

End of module Thank you for your attention! 13 | HPV vaccine attributes and

End of module Thank you for your attention! 13 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM

References l HPV vaccine introduction into national immunization programmes: Information for programme managers and

References l HPV vaccine introduction into national immunization programmes: Information for programme managers and health workers. WHO 2014 l Gardasil/Silgard. TM package inserts. Merck & Co, Inc. 2009 14 | HPV vaccine attributes and storage conditions, | March 2021 Module 2 Gardasil. TM