Erectile Dysfunction and Cardiovascular Disease ED and Cardiovascular

Erectile Dysfunction and Cardiovascular Disease

ED and Cardiovascular Diseases

Malattie cardiovascolari e disfunzione erettile • Alterazione vascolare • Aterosclerosi diffusa, ostruzione al flusso ematico • Produzione di EDRF • Peptidi vasoattivi • Sindrome dismetabolica • Terapia farmacologica • Psicologica

Malattie cardiovascolari e disfunzione erettile Effetto della terapia farmacologica • Diuretici • Beta-bloccanti • Ca- antagonisti Verapamil Diltiazem Amlodipina • ACE-Inibitori • ATII antagonisti • Alfa-litici Frequente Frequente Raro Potenziamento erezione

Study Design 3 months Run in Sildenafil Atenolol - do not know drug Atenolol - do not know side effects Atenolol - know side effects Placebo Sildenafil Placebo Report of ED QOL Questionnaire Silvestri et al. In Press Eur Heart J 2003

Beta-blockers and Report of ED P<0. 01 P<0. 05 Comparisons vs pts blinded on treatment drug Silvestri et al. In Press Eur Heart J 2003

Effect of Sildenafil Citrate and Placebo in Patients Reporting ED Silvestri et al. In Press Eur Heart J 2003

Incidence of Cardiovascular Disease in Patients Referred for ED Study Objective · Evaluate cardiovascular risk and incidence of cardiovascular disease in cardiac asymptomatic patients with ED Study esign · Indication of exercise ECG and eventually to coronary angiography to 50 cardiac asymptomatic patients with suspected vasculogenic ED Pritzker MR. Circulation. 1999; 100 (suppl 1): I-711. Abstract 3751

Cardiovascular Disease in Patients with ED · In 40 patients out of 50 (80%) there was presence of multiple risk factors for CAD - Family history (n=32) - cigarette smoking (n=40) - total cholesterol >200 mg/dl (n=35) - HDL-c <40 mg/dl (n=18) - Hypertension (n=24) - Sedentary life style (n=38) - diabetes (n=10) · Exercise ECG was positivein 28/50 pazients · Coronary angiography was performed in 20 patients and showed - proximal LAD or 3 vd in 6 pts - 2 vd in 7 - Single vessel disease in 7 pts Pritzker MR. Circulation. 1999; 100 (suppl 1): I-711. Abstract 3751

ED and Cardiovascular Disease · Asymptomatic patients with vasculogenic ED have a high incidence of CAD and high prevalence of CAD risk factors - but only a minority undergoes cardiovascular screening · Screening for cardiovascular disease in patients with vasculogenic ED may help to identify patients at high risk of cardiovascular events Pritzker MR. Circulation. 1999; 100 (suppl 1): I-711. Abstract 3751

Cardiac Contraindications to Sexual Activity • Acute Ischemic Syndromes • Severe Heart Failure (NYHA IV) • Severe malignant effort-induced tachyarrhythmia ACC/AHA Clinical Statement

Myocardial Ischemia During Sexual Activity in Patients with CAD All Patients with myocardial ischemia during sexual activity had also ischemia on Holter ECG monitoring Drory et al Am J Cardiol 1995

Myocardial Ischemia During Sexual Activity in Patients with CAD • In 19 pts with CAD during sexual activity ß-blockers completely abolished ECG changes and symptoms Drory et al Am J Cardiol 1995

Sildenafil Use and Myocardial Ischemia in Patients with CAD • • Exercise tolerance Ischemic treashold Effect of Sildenafil on Myocardial Ischemia in patients with CAD on therapy

Use of Sildenafil in Patients with CAD Using NItrates • Chronic use of nitrats has no beneficial efect upon cardiovasular mortality and morbidity and therefore can be easily changed with other drugs for the treatment of CAD in those patients requiring Sildenafil • Acute nitrate administration must be always performed under medical supervision and the dose must be adjusted according to the degree of peripheral vasodilation

Effect of Sildenafil in Patients with CAD treated with ß-blockers ** Patrizi R. et al. It Heart J 2001

Effect of Sildenafil in Patients with CAD treated with ß-blockers ** Patrizi R. et al. It Heart J 2001

Effects on Primary/Secondary End Points % change from baseline Placebo Sildenafil 30 25 * 20 15 * 26. 5 10 17. 3 * 20. 4 9. 8 5 4. 7 0 Time to limiting angina 8. 7 4. 7 Time to angina *P<0. 05 Fox KM et al Circulation 2001, abstract supplement 3. 9 Time to 1 mm ST-segment depression Exercise duration

Trimetazidine and Nitrates on Total Ischemic Burden P=0. 07 between treatments Rosano et al Eur Heart J 2003 (abstr)

Trimetazidine and Nitrates on Ischemic Episodes During Sexual Activity P<0. 04 Rosano et al Eur Heart J 2003 (abstr)

Trimetazidine vs Nitrates on the Control of Anginal Episodes p<0. 01 vs baseline p=0. 048 vs nistrates Rosano et al Eur Heart J 2003 (abstr) p<0. 01 vs baseline p<0. 04 vs nistrates

Trimetazidine plus Sildenafil vs Nitrates Positive Exercise Tests p<0. 05 Rosano et al Eur Heart J 2003 (abstr) p<0. 01

Trimetazidine plus Sildenafil vs Nitrates Heart Rate and Blood Pressure Rosano et al Eur Heart J 2003 (abstr)

Trimetazidine plus Sildenafil or Nitrates on Exercise Test Parameters Rosano et al Eur Heart J 2003 (abstr) P<0. 01 for all comparisons TMZ+S vs Baseline P<0. 05 for all comparisons TMZ+S vs Nitrates+P

Trimetazidine plus Sildenafil or Nitrates on ST segment Depression P=0. 048

Conclusions l l Sildenafil has positive effect on cardiac haemodynamics and increase coronary blood flow The effect of Sildenafil on blood pressure is minimal Sildenafil has a positive effect on exercise-induced myocardial ischemia in patients with CAD The use of sildenafil in patients with myocardial ischemia well controlled by anti-anginal drugs is safe