ePreference A Tool for Incorporating Patient Preferences into
- Slides: 52
e-Preference: A Tool for Incorporating Patient Preferences into Health Decision Aids Amar K. Das, MD, Ph. D Assistant Professor Departments of Medicine (Medical Informatics) and Psychiatry and Behavioral Sciences Stanford University
Outline § § Health decision aids Clinical example e-Preference approach Prototype system and evaluation
Health Decisions in Aging § Older individuals often face complex health decisions involving significant risk of morbidity and/or mortality § Patient participation is desirable in such decisions § Clinicians’ ability to facilitate shared decision making varies
Health Decision Aids § Focus typically on Improvements in patient knowledge Explanation of treatment alternatives Communication of risk
HDA Presentation § Non-interactive formats Brochure (paper booklet or Web based) Audiotape Video § Interactive formats Decision board Computer Multimedia
Outline § § Health decision aids Clinical example e-Preference approach Prototype system and evaluation
Atrial Fibrillation § Atrial fibrillation leads to a significant risk of stroke, ranging from 1% to 15% per year, based on patient factors § Anticoagulation therapy (warfarin) can reduce the risk of stroke by approximately two thirds, but incurs a risk of major bleeding complications of 1% to 3% per year
Measuring Preferences § Eight studies that modeled treatment preferences of patients with atrial fibrillation § Studies used three methods Probability tradeoff technique Decision aid Decision analysis (Man-Son-Hing et al. , 2005)
Audiobooklet (Man-Son-Hing et al. , 2000)
Audiobooklet (Man-Son-Hing et al. , 2000)
Audiobooklet (Man-Son-Hing et al. , 2000)
Decision Analysis (Protheroe et al. , 2000)
Decision Analysis (Protheroe et al. , 2000) Decision Analysis Guideline Treat Do not treat Total Treat 48 22 70 Do not treat 11 16 27 59 38 97 28 on treatment 17 on treatment
Decision-Support Tool (Thomson et al. , 2002)
Decision-Support Tool (Thomson et al. , 2002)
HDA Limitations § Typically designed for one type of health decision § May not provide patient-specific information on alternatives and risks § May be only accessible in particular settings § Does not have readily modifiable design
Design Desiderata for HDAs § We need a design that can Be tailored to specific health problems Incorporate patient-specific data Be accessible via the Internet Be easily modified
Outline § § Health decision aids Clinical example e-Preference approach Prototype system and evaluation
Motivation for e-Preference § Create an environment for clinical experts and software developers to design and implement HDAs § Based on our research group’s long standing interest in developing customizable and reusable software architectures for decision support
EON Architecture End-User Application Protégé Problem-Solving Method Query Engine Protocol KB Patient Database
Design of e-Preference § A set of software methods for Knowledge representation Decision-analytic computation Data access from existing database Web-based multimedia presentation
e-Preference Architecture HDA FLAIR Protégé Netica Query Engine KBDM Patient Database
Knowledge-Based Decision Model § Encode concepts related to Influence diagrams Health decisions and outcomes Risk factors Patient preferences Relationships between these factors
Netica
FLAIR
Aristotle’s Categories Supreme genus: Differentiae: SUBSTANCE material Subordinate genera: Differentiae: BODY animate Subordinate genera: Differentiae: inanimate sensitive MINERAL insensitive ANIMAL rational Species: Individuals: SPIRIT LIVING Proximate genera: Differentiae: immaterial PLANT irrational HUMAN Socrates Plato BEAST Aristotle …
The NCI Thesaurus
Structuring Knowledge
Web Ontology Language § A Semantic Web standard to use ontologies to represent knowledge on the Internet § OWL can be used to build ontologies of highlevel descriptions, based on three concepts: Classes (e. g. , Influence Diagram, Nodes, Patient) Properties (e. g. , has_node, has_disease) Individuals (e. g. , “atrial fibrilaton”)
OWL Example Patient Influence Diagrams has_chance_node AF E. My. Chart has_model has_diagnosis Diagnoses AF DM Nodes Decision Chance Outcome
Semantic Web Rule Language § A language for expressing logical rules in terms of OWL concepts § Rules in SWRL can be used to deduce new knowledge about an existing OWL ontology Patient(? pt) ^ has_dx(? pt, ? dx) ^ has_model(dx, ? hda) activate_HDA(? pt, ? hda)
Making Restrictions
Generating a Decision Model
Remaining Challenges § Modeling and editing probabilities in Protégé OWL § Generating interface based on modified influence diagram
KBDM Approach § Advantages Ability to modify knowledgebase and create tailored decision model for HDA § Disadvantages Efforts needed for acquiring and maintaining knowledge
Outline § § Health decision aids Clinical example e-Preference approach Prototype system and evaluation
Conclusions § HDAs can help to incorporate patient preferences into shared decision making § The knowledge used in developing HDAs using decision analyses can be encoded § Such knowledge can be used to generate and tailor HDAs
Acknowledgments Stanford Medical Informatics Bilal Ahmed Yael Garten Jeremy Robin Daniel Rubin Ravi Shankar Samson Tu Center for Primary Care and Outcomes Research Mary Goldstein Doug Owens Tamara Sims NIA and CADMA for funding support
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