ENZYMES 8 Dr AQSA MALIK DIAGNOSTICALLY IMPORTANT ENZYMES

ENZYMES- 8 Dr. AQSA MALIK

DIAGNOSTICALLY IMPORTANT ENZYMES ENZYME PRINCIPLE SOURCE Principle clinical use Acid phosphatase PROSTRATE , RBC’s Carcinoma of prostrate Aldolase SK, Heart Muscular dystrophies Amylase Salivary glands, pancreas, Pancreatic disease Choline esterase Liver Organophosphorus insectisides poisoning, hepatic disease

Glutamate dehydrogenase Liver Hepatic paranchymal disease -DO- Isocitrate dehydrogenase Liver Glucose-6 phosphate dehydrogenase Lipase Liver Hemolytic disorders Pancrease Acute pancreatitis 5 -Nucleotidase Liver Hepatobiliary disease

ENZYMES AS MEDICINES Enzyme substitution in digestive distubances Blood coagulation (Thrombin) To increase blood supply to tissues (Kallekrein) Locally applied enzyme preparations (Hyaluronidase, Trypsin, Chymotrypsin)

Enzyme inhibitors as medicines Example: ACE Inhibitors (Captopril) hyperetension L. DOPA ( DOPA decarboxylase) Parkinsonism NSAIDS (COX 1 and COX 2) Fever, arthritis Levostatin (HMG Co. A reductase) hypercholesterolemia Omeprazole (proton pupm) peptic ulcer

DISEASES CAUSED BY DEFICIENCY OF ENZYMES. Phenylketoneuria Albinism Maple syrup urine disease Glycogen storage diseases Lipid storage diseases Lactase deficiency

DISEASES CAUSED BY EXCESSIVE ENZYME ACTIVITIES. Phosphoribosyl pyrophosphate[PRPP]synthase. δALA synthase