ENTEROTOXIGENIC BACTEROIDES FRAGILIS ETBF Bacteroides fragilis toxinBFT 1983

新衍生的食品中毒細菌 ENTEROTOXIGENIC BACTEROIDES FRAGILIS (ETBF)

Bacteroides fragilis toxin(BFT) 1983年在羊群腹瀉的糞便中發現, 刺激羊的結腸 的分泌反應 1987年在急性腹瀉成人和小孩的糞便中發現 依據能否分泌BFT來將菌種分類為 enterotoxigenic Bacteroides fragilis(ETBF) nonenterotoxigenic Bacteroides fragilis(NTBF) 有3種BFT異構體, 即BFT-1 , BFT-2 , BFT-3

鑑定&耐受性 • • • 用 primers 404/407 和PCR 去鑑定B. fragilis enterotoxin (fragilysin) 基因 菌株對抗生素的耐受性由藥物敏感性測試(Etest) 決定 (對amoxicillin/clavulanic acid, imipenem and metronidazole是 susceptible ) 在體外(in vivo)實驗中, 和 beta-lactamase inhibitors, carbapenems and metronidazole結 合的beta-lactams 最有效用

Gram stain of Enterotoxigenic B. fragilis (ETBF) under oil immersion. 100 x.

Tumors in the colons of multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF) for 3 months compared to Min mice not colonized with ETBF. The colons are stained with methylene blue.

References： • • • CAT. INIST Cat. inist or about 15 million bibliographic records (back to 1973) of documents held in the INIST/CNRS collections and covering all fields of worldwide research in Science, Technology, Medicine, Humanities and Social Sciences. http: //cat. inist. fr/? a. Modele=affiche. N&cpsidt=3582450 Myers LL, Shoop DS, Stackhouse LL, Newman FS, Flaherty RJ, Letson GW, Sack RB. Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea. J Clin Microbiol. 1987 Dec; 25(12): 2330 -3. Vu Nguyen T, Le Van P, Le Huy C, Weintraub A. Diarrhea caused by enterotoxigenic Bacteroides fragilis in children less than 5 years of age in Hanoi, Vietnam. Anaerobe. 2005 Feb-Apr; 11(1 -2): 109 -14. Epub 2004 Dec 9. http: //www. blackwellpublishing. com/eccmid 14/abstract. asp? id=14528 http: //www. cqvip. com/onlineread. asp? ID=15949818&SUID=EGBNBFDH DNCBCOPIBOLGEMCBCDOIPNFP#