Empowering Target Identification at GSK Giovanni M DallOlio

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Empowering Target Identification at GSK Giovanni M Dall’Olio, Target Sciences, GSK 1

Empowering Target Identification at GSK Giovanni M Dall’Olio, Target Sciences, GSK 1

Target Sciences and the Drug Discovery Process at GSK Target Sciences Target ID Target

Target Sciences and the Drug Discovery Process at GSK Target Sciences Target ID Target validation Lead ID Lead Op Preclinical Clinical Earm and Earm, Drug Discovery Today 2014 Empowering Target Identification at GSK 2

What evidence is needed for a convincing target? Genetic evidences Literature Mining Public databases

What evidence is needed for a convincing target? Genetic evidences Literature Mining Public databases Data Integration Experimental validation Empowering Target Identification at GSK Image Source: http: //ebi. ac. uk 3

Data and Scientific Computing Plan Communication and Dataset Expertise Data Ingestion and Integrity Technology

Data and Scientific Computing Plan Communication and Dataset Expertise Data Ingestion and Integrity Technology support Presentation title • Who is using dataset X in TSci? • Face 2 Face strategy • What are the best procedures to import a new dataset? • How to handle dataset updates and cleaning procedures? • Is there anything better than CSV file to store and query data? 4

Communication strategy – Face 2 Face meetings Strategy of 10 -20 F 2 F

Communication strategy – Face 2 Face meetings Strategy of 10 -20 F 2 F meetings per quarter • Who is using which dataset and how? • Which other datasets can be used? • Are there any data access issues? Presentation title 5

How long does it take to import a dataset? What is the business value

How long does it take to import a dataset? What is the business value of this dataset? 2 -3 days How is the Data generated? 3 -4 days Import the dataset, (cleaning, ID mapping, DBs) Optimization (databases, integration) Several hours/days Days/weeks Data managing in TSci Where to store it, who will access it? 2 -3 meetings Documentation, Maintenance, Integration Long-term committment 6

Database Technology support https: //www. mysql. com/ https: //neo 4 j. com/ Presentation title

Database Technology support https: //www. mysql. com/ https: //neo 4 j. com/ Presentation title http: //hadoop. apache. org/ https: //www. w 3. org/TR/rdf-sparql-query/ http: //hadoop. apache. org/ https: //www. sqlite. org/ 7