Embase Find quick relevant answers to your biomedical

Embase Find quick, relevant answers to your biomedical questions

Section 1. Review / Confirm understanding of your research needs

Section 1. Your challenges & Research Needs • Conduct systematic reviews of the literature • Set up complex search strategies and alerts for stakeholders and departments • Search Medline and Embase together • Set up and distribute alerts relating to evidence-based medicine • Access the most up to date information related to a disease that you are tracking • Make sure that all relevant information is disseminated throughout the organization • Monitor and track all adverse events for early and complete detection of any and all adverse effects (signaling) • Make sure you respond to your internal stakeholder’s request in a timely manner

Section 2. Evidence Based Medicine / Systematic Searching

Section 2. “How do you know if one treatment will work better than another, or if it will do more harm than good? ” Cochrane Reviews are systematic reviews of primary research in human health care and health policy, and are internationally recognized as the highest standard in evidence-based health care. They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting. They are published online in The Cochrane Library.

Section 2. “How do you know if one treatment will work better than another, or if it will do more harm than good? ” Each systematic review addresses a clearly formulated question. For example: Can antibiotics help in alleviating the symptoms of a sore throat? All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence.

Section 2. Case Study: Embase & Evidence Based Medicine A real example of the high risks of NOT using Embase

Section 2. Medicine Without Evidence Johns Hopkins’ Tragedy: Could Librarians Have Prevented a Death? Source: http: //newsbreaks. infotoday. com/nbreader. asp? Article. ID=17534

Section 2.

Section 2.

Section 2. EBM Terms in Embase / Emtree via Advanced Limits in Advanced Search via Emtree

Section 3. What is Embase and How it Supports Academic Institutions

Section 3. What is Embase? Embase is the world’s most comprehensive, intelligent biomedical research tool, providing the drug and drug-related research community with reliable and authoritative content, to advance new biomedical and pharmaceutical discovery. Confidence Find all relevant articles that may not otherwise be found by alternative databases Deep Biomedical Indexing All relevant, up-to-date, biomedical information from the research literature Precise Retrieval Deep and focused research through powerful retrieval tools

Section 3. How Embase Delivers Value… . . . by including literature and information resources in a timely manner. . . by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc. Conference proceedings Scientific Journals In Press (unpublished) We make sure you don’t miss any biomedical literature Deep indexing using own taxonomy (EMTREE) They only close alternative is reading all the articles Very powerful Search Environment Good precision and recall balance . . . by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set . . . by allowing users to automate searching and result management Automation and documentation

Section 3. 1 Content

Section 3. 1 Content Overview Emtree: Biomedical thesaurus, over 60 k terms Embase: Fully indexed: Over 7, 700 journals (including MEDLINE), 1950 MEDLINE: 2, 500 journals unique to Embase, mapped to Embase indexing, 1950 - (including MEDLINE Classic) AIP and In Process: Indexing added, from 2009 Embase Classic: Digitally scanned and re-indexed, 1947 -1973 1947 1950 And counting… 2, 700 records added per day 1, 000 records added per year Conference Abstracts: Indexing added, from 2009 1974 2009

Section 3. 1 Embase Scope & Coverage (2012) Pharmacology & Taxicology 12% General Clinical Medicine 11% Genetics, Biochemistry & Molecular Biology 10% Neurology & Behavioral Medicine 8% Microbiology & Infectious Disease 7% Cardiology & Hematology 6% Psychiatry & Mental Health 6% Oncology 5% Healthcare Policy & Management 4% Allergy & Immunology 4% Pediatrics 4% Endocrinology & Metabolism 3% Obstetrics & Gynecology 3% Biomedical Engineering & Medical Devices 3% Anesthesiology & Intensive Care 3% Gastroenterology 2% Respiratory Medicine 2% Nephrology & Urology 2% Dermatology 2% Other topics 28% Including public health, basic biomedical science and topics included from MEDLINE

Section 3. 1 Embase vs MEDLINE – Scope Similar overall pattern of coverage. . . but with two major differences 1. Pharmacology & toxicology Embase: 11. 2% (889 titles) MEDLINE: 8. 3% (465 titles) 2. General clinical medicine Embase: 10. 5% (835 titles) MEDLINE: 8. 9% (495 titles)

Section 3. 1 Embase vs MEDLINE – Searching the Difference

Section 3. 1 Embase Records

Section 3. 1 Embase Records Medline on Pub. Med 1. 0 m 800 K 600 K 400 K 200 K 01 02 03 04 05 06 07 08 09 10 11

Section 3. 1 Embase (Active) Journals in 2012 Embase: now covers 7960 journals (20 March 2012) Indexed at Embase (5396 titles) Indexed by MEDLINE (e. g on Pub. Med) (5592 titles) 2368 journals Indexed at Embase Unique to Embase Search: [embase]/lim 3028 journals 2564 journals Indexed at Embase Also covered by MEDLINE Indexed by MEDLINE Also in MEDLINE Search: [embase]/lim AND [medline]/lim NOT [embase]/lim

Section 3. 1 Journal Articles Conference Abstracts 1. 0 m 800 K 600 K 400 K 200 K 01 02 03 04 05 06 07 08 09 10 11

Section 3. 2 Indexing (Emtree Thesaurus)

Section 3. 2 Deep Indexing – EMTREE Emtree is a Life Science Thesaurus. A controlled vocabulary for Biomedicine and related Life Sciences ü Easy to Search Over 60, 000 preferred terms and more than 270, 000 synonyms ü Comprehensive Drug Searching Chemical names, trade names, laboratory/research codes, and more than 28, 000 generic drugs and chemicals (FDA, EMEA and WHO) ü Up-To-Date The latest drugs, diseases, organisms and procedures are indexed and added annually ü Inclusive Terminology All Me. SH terms, with links to more than 20, 000 CAS registry number

Section 3. 2 Deep Indexing – EMTREE 60 K terms (>260, 000 synonyms) and all Me. SH terms 29 K drug and chemical terms Emtree updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non-Proprietary Names (INNs) described by WHO from 2000. What is mapping? Mapping means that searchers get the same results regardless of which term they use, e. g. Vioxx (synonym) or rofecoxib (the preferred term).

Section 3. 2 Deep Indexing – EMTREE Database Embase Pub. Med Thesaurus Search Emtree 'monoclonal antibody'/exp/dd_dt AND 'breast cancer'/exp/dm_dt AND [2009 -2010]/py [Note: dt = drug therapy] Me. SH "Antibodies, Monoclonal/therapeutic use“[Mesh] AND "Breast Neoplasms/drug therapy"[Mesh] Limits: Publication Date from 2009 to 2010 Embase vs. Pub. Med : in-depth indexing + Emtree structure Result 2075 357

Section 3. 2 Embase vs Pub. Med 2 thesaurus assisted searches but different results!

Section 3. 2 Embase vs Pub. Med This article, although present in Medline, is not indexed with ‘digoxin’ and therefore our search for ‘digoxin’ and ‘antibacterial agents’ did not find this article – it’s found in Embase.

Section 3. 2 Embase vs MEDLINE – Randomized Controlled Trails Language Embase on Elsevier Medline on Ovid Embase Advantage Percent Turkish 613 75 538 717% Korean 134 46 88 191% Portuguese 712 442 270 61% Dutch 606 442 164 37% Chinese 5366 3945 1421 36% Polish 491 434 57 13% Spanish 2316 2137 179 8% French 3952 3904 48 1% German 8393 8566 -173 -2%

Section 3. 2 Embase vs MEDLINE – Searching for Drugs Product Name 2 Search Term Citations Emtree Preferred Term Me. SH Preferred Term or Substance Name 3 Embase Medline Liptor Atrovastatin 3 7, 668 1, 654 Advair Fluticasone propionate plus Salmeterol 3 839 39 Plavix Clopidogrel 3 9, 552 1, 613 Nexium Esomeprazole Omeprazole 4 1, 493 1, 558 Norvasc Amlodipine besylate Amlodipine 4 439 621 Enbrel Etanercept TNFR-Fc fusion protein 4 5, 197 1, 375 Zyprexa Olanzapine 3 7, 775 1, 498 Remicade Infliximab 3 8, 223 2, 461 Diovan Valsartan 3 2, 725 508 Risperdal Risperidone 7, 991 1, 488