ELSO Registry Data Summary January 2017 350 9000

ELSO Registry Data Summary January 2017

350 9000 300 8000 7000 250 6000 200 5000 150 4000 3000 100 2000 50 Number of Runs Number of Centers Active ECLS Centers 1000 0 0 2016 2014 2012 2010 2008 2006 2004 2002 2000 1998 1996 1994 1992 1990 Centers Cases 2 ELSO Registry January 2017

Overall Patient Outcomes 3 ELSO Registry January 2017

Runs by Year 100% Adult ECPR Ped ECPR 80% Neo ECPR Adult Card Ped Card 60% Neo Card Adult Pulm Ped Pulm 40% Neo Pulm 20% 4 ELSO Registry January 2017 16 20 14 20 12 20 10 20 08 20 06 20 04 20 02 20 00 20 98 19 96 19 94 19 92 19 19 90 0%

1600 35000 1400 30000 Annual Runs 1200 25000 1000 20000 800 15000 600 10000 400 5000 200 ELSO Registry January 2017 5 20 1 13 1 20 9 20 1 7 20 0 5 20 0 3 20 0 1 20 0 9 20 0 7 19 9 5 19 9 3 19 9 19 8 5 9 0 7 0 Cumulative Runs Neonatal Respiratory Cases

Neonatal Diagnoses and Survival 94% 10000 9000 51% 8000 7000 Total Runs 6000 77% 5000 4000 72% 84% 3000 2000 1000 6 62% 61% 0 CDH MAS PPHN/PFC RDS Sepsis Pneumonia Died 3862 586 1188 251 804 Surv 4021 8488 3948 1309 2111 ELSO Registry January 2017 79% Other 159 Air Leak Syndrome 35 218 99 1688 1046

Neonatal Cases by Year and Diagnosis 100% Others Sepsis 80% RDS PPHN/PFC 60% MAS CDH 40% 20% <= 87 19 89 19 91 19 93 19 95 19 97 19 99 20 01 20 03 20 05 20 07 20 09 20 11 20 13 20 15 0% 7 ELSO Registry January 2017

Neonatal Cases by Diagnosis 8 ELSO Registry January 2017

Initial Mode of Neonatal Respiratory Support VA 72% VA VV VVA Unknown 0% Unknown VVA 0% Other 0% VV 27% 9 ELSO Registry January 2017

Neonatal Survival by Diagnosis and Year 100% 75% 50% 25% 0% <=87 1989 1991 1993 1995 1997 1999 2001 2003 2005 2007 2009 2011 2013 2015 1 CDH 10 2 MAS 3 PPHN/PFC ELSO Registry Jan 2017 4 RDS 5 Sepsis 6 Other

Pediatric Respiratory Cases 700 9000 Annual Runs 7000 500 6000 400 5000 300 4000 3000 2000 1000 11 ELSO Registry January 2017 15 13 11 09 07 05 03 01 99 97 95 93 91 0 89 87 0 Cumulative Runs 8000 600

Pediatric Diagnoses and Survival 3000 52% 2500 2000 Total Runs 65% 55% 1500 1000 500 67% 0 12 56% 59% Bacterial pneumonia 317 Aspiration pneumonia 74 ARDS Died Viral pneumonia 606 Surv 1150 469 155 ELSO Registry January 2017 Other 348 Acute resp failure 635 456 802 1551 1417

Pediatric Cases by Year and Diagnosis 100% Others ARF 80% ARDS Aspiration 60% Bact Pneum 40% Viral Pneum 20% <= 87 19 89 19 91 19 93 19 95 19 97 19 99 20 01 20 03 20 05 20 07 20 09 20 11 20 13 20 15 0% 13 ELSO Registry January 2017

Pediatric Cases by Diagnosis 14 ELSO Registry January 2017

Pediatric Survival by Diagnosis and Year 100% 75% 50% 25% Viral Pneum 15 Bact Pneum Aspir ARDS ELSO Registry January 2017 ARF Others 15 20 13 20 11 20 20 09 07 20 05 20 03 20 01 20 99 19 97 19 95 19 93 19 91 19 19 89 0%

Initial Mode of Pediatric Respiratory Support VA 54% Other 1% VV Unknown VVA 0% Other Unknown, 1% VV 44% 16 VA ELSO Registry January 2017

Adult Respiratory Cases 2500 9000 Annual Runs 2000 7000 6000 1500 5000 4000 1000 3000 2000 500 1000 17 ELSO Registry January 2017 13 11 09 07 05 03 01 99 97 95 93 91 89 0 87 0 Cumulative Runs 8000

Adult Cases by Diagnosis 18 ELSO Registry January 2017

Adult Diagnoses and Survival 6000 56% 5000 4000 Total Runs 3000 2000 65% 1000 66% 0 19 56% 61% 57% Bacterial pneumonia 564 Aspiration pneumonia 65 ARDS Died Viral pneumonia 434 Surv 841 896 128 ELSO Registry January 2017 Other 665 ARF, non. ARDS 903 880 1202 2818 2210

Adult Survival by Diagnosis and Year 100% 75% 50% 25% 19 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 1 20 2 1 20 3 1 20 4 1 20 5 16 0% Viral Pneum 20 Bact Pneum Aspir ELSO Registry January 2017 ARDS ARF Others

Initial Mode of Adult Respiratory Support Unknown 4% Other 1% VVA 1% VA 13% VA VV Other Unknown VVA VV 82% 21 ELSO Registry January 2017

Neonatal Cardiac Cases By Year Annual cases 7000 500 6000 400 5000 4000 3000 2000 1000 0 22 ELSO Registry January 2017 20 16 20 14 20 12 20 10 20 08 20 06 20 04 20 02 20 00 19 98 19 96 19 94 19 92 19 90 19 88 0 Cumulative cases 8000 600

800 10000 9000 8000 7000 6000 5000 4000 3000 2000 1000 0 Annual cases 700 600 500 400 300 200 100 0 88 90 92 94 96 98 00 02 04 06 08 10 12 14 16 23 ELSO Registry January 2017 Cumulative cases Pediatric Cardiac Cases By Year

2500 12000 10000 8000 1500 6000 1000 4000 500 2000 0 0 88 90 92 94 96 98 00 02 04 06 08 10 12 14 16 24 ELSO Registry January 2017 Cumulative cases Annual cases Adult Cardiac Cases By Year

Cardiac ECLS by Diagnosis Neonatal 25 ELSO Registry January 2017

Cardiac ECLS by Diagnosis Pediatric 26 ELSO Registry January 2017

Cardiac ECLS by Diagnosis Adult 27 ELSO Registry January 2017

Cardiac Survival by Diagnosis and Year Neonatal 100% 75% 50% Congenital Defect Cardiomyopathy 28 Cardiac Arrest Myocarditis ELSO Registry January 2017 Cardiogenic Shock Others 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 0% 1991 25%

Cardiac Survival by Diagnosis and Year Pediatric 100% 75% 50% Congenital Defect Cardiomyopathy 29 Cardiac Arrest Myocarditis ELSO Registry January 2017 Cardiogenic Shock Others 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 0% 1991 25%

Cardiac Survival by Diagnosis and Year Adult 100% 75% 50% Congenital Defect Cardiomyopathy 30 Cardiac Arrest Myocarditis ELSO Registry January 2017 Cardiogenic Shock Others 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 0% 1991 25%

160 1800 140 1600 120 1400 1200 1000 80 800 60 600 40 400 20 200 ELSO Registry January 2017 6 20 1 4 20 1 2 20 1 0 20 1 8 20 0 6 20 0 4 20 0 2 20 0 0 20 0 8 19 9 31 6 0 4 0 Cumulative Runs Annual Runs Neonatal ECPR Cases

400 4000 3500 3000 2500 2000 1500 1000 50 500 32 ELSO Registry January 2017 15 13 11 09 07 05 03 01 99 97 95 0 92 0 Cumulative Runs Annual Runs Pediatric ECPR Cases

900 4000 800 3500 700 3000 600 2500 2000 400 1500 300 200 100 500 33 ELSO Registry January 2017 15 13 11 09 07 05 03 01 99 97 95 0 92 0 Cumulative Runs Annual Runs Adult ECPR Cases