Ecotoxicology in a DEB context 2019 Bas Kooijmanvu

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Ecotoxicology in a DEB context 2019 Bas. Kooijman@vu. nl http: //www. bio. vu. nl/thb

Ecotoxicology in a DEB context 2019 Bas. [email protected] nl http: //www. bio. vu. nl/thb Brest, 2019/04/06/09: 00

Contents Chemical stress Research - in biology - in energetics - in stress Meta-models

Contents Chemical stress Research - in biology - in energetics - in stress Meta-models 2019

Stress stress 2019 0 too little enough too much factor No stress for a

Stress stress 2019 0 too little enough too much factor No stress for a range of factor values Stress = difference from no-stress Consequence: We need to know the no-stress situation to recognize stress, including `variability’

Arrhenius relationship 2019 ln pop growth rate, h-1 stress 103/T, K-1 103/TH 103/TL

Arrhenius relationship 2019 ln pop growth rate, h-1 stress 103/T, K-1 103/TH 103/TL

Stress by chemical compounds 2019 Par values depend on internal concentration: transport 1 compartment

Stress by chemical compounds 2019 Par values depend on internal concentration: transport 1 compartment 1 -1 compartment partition coef = internal conc external conc dim(partition coef) = dim(accum rate) = vol environ vol organism time × vol environ dim(elim rate) = 1 time

n, n-compartment models 1, 1 -comparment model 2019 film model Compound can cross, interface

n, n-compartment models 1, 1 -comparment model 2019 film model Compound can cross, interface between media with different rates vice versa sub-layers with equal rates for all sublayers

Meta models 2019 models for parameter values Null model: • • group pars in

Meta models 2019 models for parameter values Null model: • • group pars in either intensive or extensive find a simple function of pars that contains 1 extensitive par x example: max struct length for standard DEB model, example: bioconc factor for 1 compartment model find ratios of extensive pars that are intensive and contains x this links all extensive parameters to x write property of interest as function of pars and study how is scales with x

Primary parameters standard DEB model 2019 Kooijman 1986 J. Theor. Biol. 121: 269 -282

Primary parameters standard DEB model 2019 Kooijman 1986 J. Theor. Biol. 121: 269 -282

 time to reach x-level saturation Primary parameters 1 -1 compartment, film model 2019

time to reach x-level saturation Primary parameters 1 -1 compartment, film model 2019 film model Kooijman et al 2007 SAR & QSAR Environ. Res. 18: 315 -330