Duke Breast Models Prepared for Allergan Ansys Paul

Duke Breast Models Prepared for Allergan & Ansys Paul Segars Greg Sturgeon

Breast MRI (prone) Types of Data Patient CT (supine) Resolution: 0. 85 mm XY; 1. 6 mm Z Breast CT (prone) Resolution: 0. 97 mm XY; 3. 27 mm Z Resolution: 0. 155 to 0. 25 mm

Two Sources of Breast Models Full Body XCAT Models Isolated High Resolution Breast Models • Based on patient CT data • Segmented breast CT data • with ‘morphed’ structures

Full Body XCAT Models • Based on patient CT data • ~3000 structures modeled as individual NURBS surfaces. • Some objects built from patient specific segmentations • Some ‘morphed’ from detailed reference phantoms

Extrapolating the FOV • Part of the torso or breast may be outside of the reconstruction in some CT scans. • NURBS surfaces created for the overall body habitus and breasts. • Geometry is extrapolated from imaging and patient BMI. • Full-body XCAT models do not currently have patient specific fibroglandular tissue or ducts modeled. • Possible to segment inner tissue from CT if not truncated

Variability of Full Body XCAT Models

High Resolution Breast Models • Segmented Breast CT • . 155 mm voxel resolution • Segmented into 6 classes • (skin + 4 fibroglandular levels + adipose) • Imaged in pendant geometry • Limited pectoral muscle / no chestwall

Size / Density Variability of High Resolution (isolated) Breast Models

Addition of Breast (based upon Breast CT) to XCAT model +

FE compression using template hex mesh • Modeled gravity and compression to allow for simulated mammography and breast tomosynthesis imaging. • Chest wall modeled simplistically • Patient specific chest wall information wasn’t available for these cases. • Use of template mesh allowed for easy mapping between breast geometries. • Allow for breasts to be mapped to consistent shell.

Subpopulation of breast models – mapped to consistent geometry • Subpopulation of larger less dense breasts. • Mapped to a consistent compressed breast ‘shell’. • Allows of modeling of breast texture independent of geometry.