Drugs That Alter Blood Clotting Fantastic Voyage The
Drugs That Alter Blood Clotting Fantastic Voyage
The importance of regulated clotting hemophilia VS Slide. Share Nethealth. Book. com
The importance of regulated clotting hemophilia VS Slide. Share gandhiji 40
The importance of regulated clotting southof 64. com
Background: platelets and clotting The Merck Manuals
Background: platelets and clotting
The importance of proteases https: //www. youtube. com/watch? v=FNVv. Q 788 wzk
Value of a cascade? Ken Miller, Brown University WWW. Britannica. com
Value of a cascade? Ø Amplification Ø Regulation Ken Miller, Brown University WWW. Britannica. com
Key terms Ø clotting factor Ø zymogen (proenzyme)
What would you target to inhibit clotting?
1. Inhibition of clotting factors a) Warfarin Ø Some clotting factors (prothrombin, X, VII, IX) contain several g-carboxyglutamic acid groups.
Importance of gamma carboxylic acid Ø The g-carboxyglutamic acid groups are important for interacting with phospholipid on activated platelets and damaged endothelium. https: //www. studyblue. com/notes/note/n/vpath-final/deck/6443882
Warfarin Ø Warfarin inhibits the formation of g-carboxyglutamic acid groups on clotting factors.
Warfarin – inhibition of Vitamin K regeneration
b) Other inhibitors of clotting cascade Ø Rivaroxaban (Xarelta) – binds to and inhibits factor Xa
2. Exploitation of restorative pathways a. Anti-thrombin Ø Anti-thrombin is a natural inhibitor of several clotting factors including thrombin. Ø It inhibits the clotting factor by directly binding to it. Biochemistry for Medics, N. Chhabra
Exploitation of restorative pathways a. Anti-thrombin Ø Heparin can increase the rate of clotting factor inhibition 1000 -1, 000 fold. Biochemistry for Medics, N. Chhabra
Heparin Ø Q: How would this drug be administered?
Questions for consideration: 1. Why are patients who require an immediate anti-clotting treatment often initially given heparin rather than warfarin? 2. What is an advantage of switching patients from heparin to warfarin as a long-term anti-clotting drug?
b. Tissue plasminogen activator (t. PA) Ø Converts fibrin-bound plasminogen to plasmin Ø Plasmin is a protease that then degrades the clot
Why would an ER physician may want to do some type of brain scan prior to administering t. PA to a stroke patient?
3. Back to the platelet- Inhibitors of platelet activation 123 RF. com
The activated platelet Food and Public Health 2015, 5(1): 1 -9
stimulus Vascular and Endovascular Surgery Volume 40, Number 4, 2006
Activation of fibrinogen binding Current Medicinal Chemistry, 2004, Vol. 11, No. 17 2247
The activated platelet Food and Public Health 2015, 5(1): 1 -9
ADP Vascular and Endovascular Surgery Volume 40, Number 4, 2006
ADP receptor inhibition Clopidogrel (Plavix) ADP
Inhibition of COX 1 Food and Public Health 2015, 5(1): 1 -9
Inhibition of COX 1 by aspirin Food and Public Health 2015, 5(1): 1 -9
Why so complicated? Key points?
Drug List for entire course Ø Ø Ø Warfarin Heparin Clopidogrel Aspirin Tissue plasminogen activator (t. PA)
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