Draft ICT WP 2011 12 Challenge 5 ICT

Draft ICT WP 2011 -12 Challenge 5 “ICT FOR HEALTH, AGEING WELL, INCLUSION AND GOVERNANCE” Strategic Objectives 5. 2: “Virtual Physiological Human” Joël Bacquet ICT for Health DG Information Society & Media European Commission

Draft Outline • Part I VPH overview/status

Draft Towards full picture of individual’s health status “Omics”-based personalized medicine Biochips Biosensors Genomic data Environmental Data Phenomic data ICT Systems

Draft The Virtual Physiological Human (VPH) concept Based on the ideas of the International Physiome project Baseline: • The VPH is a methodological and technological framework using advanced ICT to enable the investigation of the human body as a complex system • Inter-disciplinary research (bioinformatics, medical informatics, genomics, medicine) • STEP: pioneer FP 6 project defined the VPH research roadmap, see http: //www. europhysiome. org • VPH NOE Call 2: second VPH vision and strategy http: //www. vph-noe. eu/news/168 Goals: • Personalised (patient-specific) healthcare solutions • Early diagnostics & predictive medicine • Understanding diseases for the first time across several biological levels

Draft First VPH Call: FP 7 call 2 Technical focus: • Patient-specific computational modelling and simulation of organs targeting specific clinical needs • Data integration and new knowledge extraction Clinical focus: • Simulation environments for surgery training, planning and intervention • Prediction of disease or early diagnosis • Simulation and assessment of the efficacy and safety of specific drugs Results: • 15 projects - details in VPH resource book: http: //ec. europa. eu/information_society/activities/health/docs/projects/fp 7/binder-fp 7 vph-projects. pdf

Results of the 1 st VPH call: 15 FP 7 projects Industry Grid access CA CV/ Atheroschlerosis IP Breast cancer/ diagnosis STREP Osteoporosis IP Oral cancer/ BM D&T STREP Cancer STREP Networking No. E Vascular/ AVF & haemodialysis STREP Liver cancer/RFA therapy STREP Alzheimer's/ BM & diagnosis STREP Heart /CV disease STREP Reproduction from VPH No. E Parallel VPH projects Liver surgery STREP Heart/ LVD surgery STREP Heart /CV disease STREP Draft Security and Privacy in VPH CA Clinics

Draft Virtual Physiological Human Network of Excellence (VPH No. E) No. E: team of organisations working in key focus areas to support and enable VPH research, within and beyond the VPH Initiative • Identification of user needs, standards, ontologies, applications and development of VPH Tool. Kit • VPH training activities and materials - MSc, interdisciplinary study groups, focused journal issues, textbook • Research/news dissemination and international networking • 2 nd research roadmap on VPH • VPH 2010 conference 30 September -1 st October 2010 (http: //www. vph-noe. eu/vph 2010)

International Cooperation on VPH FP 7 call 4 Draft Focus of Call 4: • • • Interoperability (interfaces databases, web services, mark-up languages, meta-data, ontologies) Tools and services for global cooperation (for modelling/simulation, curated models, interconnected libraries) International validation environment (joint verification of clinical relevance of models) Budget: 5 M€ Results: 5 STREPs

Results of VPH call 4 : 5 STREPs Draft NMS Physiome VPHOP Sim-e-Child VPHOP MSV National Alliance for medical Imaging Computing IUPS Physiome Project

Draft Second VPH Call: FP 7 call 6 Target outcomes overview: a) Patient-specific computer based models and simulation b) ICT tools, services and infrastructures for biomedical researchers c) Evaluation and assessment of VPH Projects d) Observatory on achievements and evolution of the broader BMI field (e. g. bioinformatics, Medical informatics, neuro-informatics) a) and b) IP/STREP 61 M€ c) SA 1 M€ d) CSA 1 M€

Draft Outline • Part II VPH FP 7 Call 7 & 9

Draft WP 2011 -12 Objective 5. 2 VPH Target outcomes overview: a) Patient-specific predictive computer based models and simulation (including environmental factors) b) ICT tools, services and infrastructures to obtain more elaborate and reusable multi-scale models and larger repositories c) RTD roadmap preparing the ground for a “Digital Patient” challenge d) Early demonstrators and proof of concept of digital representations of health status. a) and b) IP/STREP 58 M€ c) CSA 1. 5 M€ d) STREP 8. 5 M€

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Focus a) Patient-specific predictive computer based models and simulation • Predictive models & simulation of major diseases integrating medical, biological and environmental data • Emphasis on influence of environmental factors on diseases • Interaction and integration of environmental factors with other health factors in developing predictive models • Applied goals, use and benefits should be demonstrated for a specific clinical need. • All major diseases targeted

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Focus b) ICT tools, services and infrastructures to obtain more elaborate and reusable multi-scale models and larger repositories Projects to address at least 1 of the 2 activities: 1. Robustness and reproducibility of VPH models • Allowing models to be re-used • Standards for models and data • Tools to support robustness and reproducibility of models 2. Development of VPH info-structure • Sustainable VPH model and data repositories • Appropriate tools to support this info-structure • Address attributes such as usability and accessibility (community acceptance) • Open environment and open-source software

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Focus a) and b) Instruments/budget: • STREP/IP • Budget: 58 M€ • Minimum 30% to STREPs; minimum 50% to IPs • A maximum of EUR 3 million will be reserved for third country participants from USA, Japan, Canada, Australia, New Zealand Call 9

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Focus c) RTD roadmap preparing the ground for a “Digital Patient” challenge • Digital representation of the different patients specific models • Provide patients with personalised and predictive care • The roadmap will provide: Ø Consolidation of research so far Ø Identify and quantify the needs Ø Develop a vision and ICT research agenda for the”Digital Patient” Instruments/budget: • One CSA max funding of 1. 5 M€ Call 7 Draft

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Focus d) Early demonstrators and proof of concept of digital representations of health status • Health status based on patient specific data and VPH models (medical, anatomical, physiological and genetic) • Innovative representations of health status • Representations usable for care, personalised prevention and research Instruments/budget: • STREP – budget: 8. 5 M€ Call 9

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Expected impacts: For all target outcomes • More predictive, individualised, effective and safer healthcare • Reinforced leadership of European industry and strengthened multidisciplinary research excellence in supporting innovative medical care

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Specific additional expected impacts: For target outcome a) • Accelerate medical knowledge discovery and management through the exploration of environmental factors in predictive models of disease For target outcome b) • Improve interoperability of Bio. Medical information and knowledge • Increase acceptance and use of realistic and validated models • Accessibility to existing knowledge by bio-medical researchers through the VPH repositories linking data with models

FP 7 ICT Objective 5. 2 – Virtual Physiological Human Draft Specific additional expected impacts: For target outcome c) • Availability of a common strategic research agenda on the “Digital Patient” between all relevant stakeholders For target outcome d) • Proven concepts of digital representations of patient health status

Draft Contact/Information • DG Information Society and Media Unit “ICT for Health” http: //ec. europa. eu/information_society/ehealth • • • Call information: http: //cordis. europa. eu/fp 7 VPH project portfolio: http: //ec. europa. eu/information_society/activities/health/docs/ projects/fp 7/binder-fp 7 vph-projects. pdf Virtual Physiological team: Joël Bacquet (Joel. Bacquet@ec. europa. eu) Amalia Vlad (Amalia-Irina. Vlad@ec. europa. eu) Karina Marcus (Karina. Marcus@ec. europa. eu)