Dr Shafiq Khan Lab Transforming Growth Factor beta

Dr Shafiq Khan Lab Transforming Growth Factor beta (TGF-b) signaling • How TGF-b promotes tumor progression • The role of the different TGF-b isoforms

Dr Jaideep Chaudhary Lab Inhibitors of Differentiation (Id) • Promotes tumor progression Viruses causing prostate cancer • Pathway of action

Dr Valerie Odero-Marah Lab Snail transcription factor • Promotes tumor progression via reactive oxygen species • Promotes metastasis to bone

Dr. Cimona V. Hinton Lab PTEN and CXCR 4 • Studying how loss of tumor suppressors permits metastasis enhancing genes. PTEN usually lost early in cancer progression CXCR 4 associated with metastasis

Dr Godwin Ananaba Lab Role of Sterols in prostate cancer • How high cholesterol and low phytosterol can promote prostate cancer • Using cyclodextran compounds as a delivery system

Sources of Funding § National Institute of Health (NIH): RCMI, P 20 § National Cancer Institute (NCI): RO 1 § Department of Defense (DOD): Idea, New Investigator, Pca Training Grant § Georgia Research Alliance (GRA): equipment and personnel

Publications and Presentations § May 2009 -April 2010: 11 journal articles § 50 presentations in national meetings

Research Facilities § § § Molecular Biology Cell Biology Structural Biology Histology Bioinformatics and Biostatistics Analytical

Collaborative Center for Cancer Genomics (CCGC) § Collaborative effort between Clark Atlanta University and Ovarian Cancer Institute at Georgia Tech § Gene expression analysis of individual patients

Prostate Cancer Tissue Bank § Collaboration between Saint Joseph’s hospital and Georgia Tech § Intend to acquire prostate cancer patient samples for analysis at the Genomics center § Intend to establish a prostate cancer tissue bank