DR R PAYNE 9 YEARS ON REBECCA P
DR. R PAYNE …. . . 9 YEARS ON REBECCA P PAYNE (@REBECCA 37704429)
STEM CELL TRANSPLANTATION
OLOGY Eberl G. et al Nature Immunology 2015 Ai Ing lim et al Cell 2017
Immunity. 2012 Oct 19; 37(4): 601– 610. Curr Opin Gastroenterol. 2015 Nov; 31(6): 449– 455.
GUT MICROBIOME STUDIES • Anaerobic chamber – Marie Curie fellowship and Newcastle University (C. Stewart) – LUSH prize (R Payne) – John Kirby – Sophie Hambleton – Chris Lamb
Year In Industry MOD Biochemistry Oxford University D. Phil (MRC funded) Goulder Lab Oxford University Post-doc Goulder Lab Research Ass. Hambleton Lab Newcastle University 2016 Part-time 60% Maternity Leave Maternity Career Break Leave Relocation! Co-author review 2 nd author paper 1 st author paper Young Investigator LUSH prize NUSCU Award 2009 2011 2012 2013 2000 2001 2005 Wellcome Career Reentry Fellowship Newcastle University Part-time 68% 2 nd author 1 st author 2017 Part-time 75% 2018 Maternity Leave Part-time 75%
…. . . SMOOTH SAILIING? 2009/2010 – Unsuccessful application to Wellcome Sir Henry Postdoctoral Fellowship Project …. . Place…. . Person…. . “Oxford-centric view of the world”…. . . . ”publication record is disappointing” 2011/2012 – Unsuccessful job interview for Post-doc position in muscoal immunology ”lab-based work not compatible with part-time working. . . ” 2013 – Left Oxford with no job, heavily pregnant and not very optimisitc. . . 2014 –Post-doc papers published; Two 2 nd author papers, Two 1 st author papers 2014 – Unsuccessful application for Newcastle Faculty Fellow 2015 – Interview for Wellcome Career Reentry Fellowship. . . unsuccessful but asked to address panels comments and re-apply 2016 – Awarded Wellcome Career Reentry Fellowship 2017 - Unsuccessful AMS Springboard Award application. . . asked to re-apply ….
• THE POWER OF COLLABORATION Reconstructing the human first trimester fetal–maternal interface usingle cell transcriptomics. Vento-Tormo R, Efremova M, Turco M, Botting R, Meyer K, Park J, Stephenson E, Payne RP, Goncalves A, Zou A, Henriksson J, Wood L, Lisgo S, Filby A, Wright G, Stubbington M, Haniffa M, Moffett A, Teichmann SA. Nature. 2018; in press • Reply to Jefferys: Declining HIV Virulence. Payne RP, Muenchhoff M, Goulder PJR. PNAS 2015 Mar Letter (online only) • Impact of HLA-driven HIV adaptation and of anti-retroviral therapy on HIV virulance. Payne RP 1, Muenchhoff M 1, Mann JK et al. PNAS 2014 Dec 16; 111(50): E 5393 -400 • Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados. Juarez-Molina CI 1, Payne R*2, Soto-Nava M 3, et al. Journal of Virology 2014 Sep 15; 88(18): 10392 -8 • Differential escape patterns within the dominant HLA-B*57: 03 -restricted HIV Gag epitope reflect distinct clade-specific functional constraints. Payne RP*, Branch S, Kløverpris H, Matthews PC et al. Journal of Virology 2014 May; 88(9): 4668 -78 • HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58: 01. Kløverpris HN 1, Stryhn A, Harndahl M, Payne R, et al. Journal of Virology 2013 Oct; 87(19): 10889 -94 • Early antigen presentation of protective HIV-1 KF 11 Gag and KK 10 Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD 8+ T cells. Kløverpris H, Payne RP, Sacha JB, Rasaiyaah JT, et al. Journal of Virology. 2013 Mar; 87(5): 2628 -38 • Co-operative additive effect between HLA alleles in control of HIV-1 viraemia is linked to breadth of CD 8+ T cell responses. Matthews P, Listgarten J, Carlson J, Payne RP, Huang KH, et al. PLo. S One. 2012; 7(10) • Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope. Matthews PC*, Koyanagi M*, Kloverpris HN *, Harndahl M, Stryhn A, Gatanaga H, Oka S, Molina CJ, Ponce HV, Rios SA, Cole D, Carlson J, Payne RP, et al. Journal of Virology: 2012 Dec; 86(23): 12643 -54 • HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunongenicity, selection pressure , and HIV immune control. Kloverpris HN, Stryhn A, Harndahl M, van der Stok M, Payne RP, et al. J Virol. 2012 Jan; 86(2): 919 -29. • HLA-A*7401 -mediated control of HIV viraemia is independent of its linkage disequilibrium with HLA-B*5703. Matthews PC, Adland E, Listgarten J, Leslie A, Mkhwanazi N, Harndahl M, Payne RP, et al. J Immunol. 2011 May 15; 186(10): 5675 -86 • Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B*2705 -restricted CD 8 + T-cells. Payne RP, Kløverpris H, Sacha JB, et al. Journal of Virology: 2010; 84(20)-10543 -57 • HLA-mediated control of HIV and HIV adaptation to HLA. Payne RP* , Matthews PC, Prado JG, Goulder PJ. Advances in Parasitology, 2009; 58: 1 -20 (Review) • HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. Matthews PC, Leslie AJ, Katzourakis A, Crawford H, Payne R, et al. Journal of Virology, 2009 May; 83(9): 4605 -15 • Adaptation of HIV-1 to human leukocyte antigen class I. Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R*, et al. Nature, 2009 Apr 2; 458(7238): 641 -5 • Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. Matthews PC, Prendergast A, Leslie A, Crawford H, Payne R, et al. Journal of Virology, 2008 Sep; 82(17): 8548 -59. • HLA class I-driven evolution of human immunodeficiency virus type I subtype c proteome: immune escape and viral load. Rousseau CM, Daniels MG, Carlson JM, Kadie C, Crawford H, Prendergast A, Matthews P, Payne R, et al. Journal of Virology. 2008 Jul; 82(13): 6434 -46 • Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression. Frater AJ, Brown H, Oxenius A, Günthard HF, Hirschel B, Robinson N, Leslie AJ, Payne R et al. Journal of Virology, 2007 Jun; 81(12): 6742 -51 • Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD 8+ T-cell epitopes. Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R et al. Journal of Virology. 2007 Apr; 81(7): 3667 -72.
A “SUCCESSFUL” SCIENTIST • Work/Life Balance • Part-time/Flexible working • Rejection • PHD is an education • Read papers • Role model/Mentor • Collaborate and be open – don’t be afraid!
A GOOD READ…. . .
REBECCA. PAYNE 2@NCL @REBECCA 37704429 Acknowledgements PID Group Sophie Hambleton Angela Grainger Florian Gothe Jarmila Spegarova Tom Sproat …and all PID members! Chris Stewart NUSCU Muz Haniffa Core Flow Facility Andy Filby GNCH Andrew Gennery Mary Slatter
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