Dr Mark Stowers Chief Operations Officer and President

Dr. Mark Stowers, Chief Operations Officer and President of North America, Inari Agriculture, Inc. Dr. Mark Stowers is the Chief Operations Officer and President of North America at Inari Agriculture, Inc. based in Cambridge, Massachusetts and West Lafayette, Indiana. Mark has the responsibility for the company’s commercial, regulatory, operations, products and supply chain activities. Before joining Inari, he was a Limagrain executive responsible for research strategy and operations serving on its Scientific Committee, Vegetables Research Committee and as the Vice President and Global Head of Research and Development at HM. Clause, a business unit of Limagrain. Previously, Mark was a senior executive with POET, Monsanto, and Eastman Kodak. In addition, he has been the CEO or founder of five in companies in sustainable agriculture, green chemistry and bio-based products. Mark holds a Ph. D. in microbiology from North Carolina State University, completed postdoctoral studies at the Boyce Thompson Institute at Cornell University and attended the Olin School of Business at Washington University – St. Louis. He is also a graduate of the Wedgeworth Leadership Institute at the University of Florida.

Generating and Leveraging Genetic Diversity to Enable Informed Crop Improvement Mark Stowers Chief Operations Officer and President - North America

GAME-CHANGERS IN AGRICULTURE Ø Ø Ø Farm Mechanization Hybridization Crop Chemicals Biotechnology Informed Breeding ATTGTATTCTCAACTTT TTTCTCACGTGTA GCTTCTAGCTTGAACAT GAAATTTCATATAACTA TTTAGACGAAGGCAATT ACGACTAAGGGTATGTT CGATAAGAAAAT ATTTTCTTAAAAATAGA

INARI COMBINES PEOPLE, KNOWLEDGE & VISION FOR CHANGE ` Ghent, Belgium Science West Lafayette, IN Product & Commercial ● ● ● Cambridge, MA HQ & Science Quick stats ● ● Diverse cross-disciplinary teams 130 FTEs at three sites >$140 m capital funding to date >90 patents filed ~2, 400 patented traits filed

INARI IS BUILDING THE WORLD’S FIRST SEED FOUNDRY™ Delivery into parent seeds Genetic technologies ● Comprehensive toolbox ● Multiple edits at the same time ● Native genes Computational science ● Virtual seed design through computational models ● Continuous feedback Data from lab, greenhouses and fields to optimize computational models Novel delivery methods that enable fast delivery into elite lines Rapid scale-up ● Collaborate with independent seed companies to accelerate impact

GENETIC DIVERSITY TOOLBOX: BROADEST IN INDUSTRY Genetic Diversity Toolbox Digital Crosses Models of plant & environment interactions Gene Knockout Disable target genes Unique to Inari Sequence Insertion Insert natural DNA Promoter Fine-tuning Adjust level of gene expression Epigenetic Fine-tuning Adjust expression without DNA changes X Create new combinations Turn off / on Regulate down / up Multiplexing 6

WHAT CROSSES, WHICH SEQUENCES AND WHICH EDITS? Deep data integration…. Levels of data integration Predictive power …drives Inari’s computational breeding and gene prioritization Gene prioritization Sequence variation Gene nomination Genetic networks and target alleles Prioritized sequences to edit with a recommendation of what type of edits Computational breeding A Cross prediction -3 +5 -2 + X B Crop models Effect of regions in genome Breeding for best performance

CREATING NEW VARIATIONS IN GENE EXPRESSION TO MODIFY PLANT ARCHITECTURE AND INCREASE YIELD Promoter fine tuning technology- Zach Lippman’s lab – exclusive license from CSHL Multiple genes at the same time

DELIVERING EDITS IN ELITE VARIETIES TO ACCELERATE DEVELOPMENT TIMELINES High Technical difficulty Novel delivery cargos ● Reproductive organs ● ● ● Agrobacterium Developmental genes Genotype independence is key to accelerate breeding timelines ● Target tissues/organs that regenerate plants directly ● Use novel delivery systems that are less invasive and more targeted to reproductive organs Biolistics Low High Genotype dependency Agrobacterium or biolistics deliver requires regeneration through tissue culture Regeneration through tissue culture is genotype dependent Tissue culture introduces epigenetic modifications Improvement in some crops (e. g corn) using developmental genes to induce somatic embryogenesis Low 9

INARI CORN PRODUCTS AND TRIALS 10

PRODUCT PIPELINE: MAJOR CROPS, BIGGEST IMPACT Row crops Corn Soybean Specialty crops Wheat Tomato Product concepts Genetic Gain Architecture for Productivity Resource Efficiency Disease Resistance

GAME CHANGING OUTCOMES TARGETED FROM SEED FOUNDRY Inari’s Seed Foundry Today +1% per year Yield focussed Performance Significant increases Yield + sustainability + health Performance 10 years ~3 years Time $20 m <$2 m Cost per variety

BUSINESS MODEL: OPPORTUNITY THROUGH PARTNERSHIP WITH INDEPENDENT SEED COMPANIES Genetic share ISC Market share 10% 40% Dominant market players US Market Share 13

IT’S A UNIQUE TIME FOR INARI Consolidation: Lack of innovation and customer focus People: Experienced Ag management, multi-dimensional diversity Starting genetic materials: Off-patent and acquired elite genetics Technologies: Computational science and gene editing emergence Go To Market: Opportunity for collaboration with independent seed cos 14

Thank you