Dr Fabio de Sousa Menezes works with the

Dr. Fabio de Sousa Menezes works with the discovery of new leads from medicinal plants (intact species) from Ireland, South America, Serbia and Thailand, aiming among other things, to achieve the isolation and validation of new compounds against several different pharmacological targets. The idea can start with any ethnopharmacological information and the goal is to finish with the pharmaceutical development of new products. His work is in the field of Applied Pharmacognosy and his research is under the NPDD group interests. Natural Products as a Source for Drug Discovery. In TCD the fundamental goal of the research in the Natural products Drug Discovery Group (NPDDG) is the isolation of new chemical entities and the evaluation of their pharmacological activity and potential as new therapeutic agents for a range of diseases. Natural Product Drug Discovery Group: Dr. Helen Sheridan (HS), Mrs Ingrid Hook (IH), Dr. John J. Walsh (JJW), Dr. Neil Frankish (NF), Dr. Fabio de Sousa Menezes (Fde. SM), Ciara Smyth (CS) (Research associate). Fde. SM Research Interests: v. Evaluation of essential oil-containing plants against bacteria, fungi and different cancer types. v. Evaluation of medicinal plants leading to the isolation and identification of compounds used for the treatment of different types of cancer. v. Evaluation of medicinal plants leading to the isolation and identification of compounds used for the treatment of diabetes. v. Evaluation of medicinal plants leading to the isolation and identification of compounds bearing anti -virus activity.

Collaborations: National: Dr. Helen Sheridan – Schoolof. Pharmacyand. Pharmaceutical. Sciences – TCD. Dr. Neil Frankish - Schoolof. Pharmacyand. Pharmaceutical. Sciences – TCD. Dr. Carlos Medina - Schoolof. Pharmacyand. Pharmaceutical. Sciences – TCD. Dr. Lidia Tajber – Schoolof. Pharmacyand. Pharmaceutical. Sciences – TCD. Dr. John Parnell–Departmentof. Botany– TCD. Dr. Graham Pidgeon–Schoolof Medicine – TCD. Dr. Fiona. Walsh–Schoolof Medicine – TCD. International: Dr. Carla Holadino Quaresma – Facultyof. Pharmacy – FURJ – Brazil. Dr. Davyson de Lima Moreira – Oswaldo Cruz Foundation – RJ – Brazil. Dr. Elis Eleutherio – Departmentof. Biochemistry – FURJ – Brazil. Dr. Celuta Sales Alviano – Departmentof. Microbiology – FURJ – Brazil. Dr. Daniela Sales Alviano– Departmentof. Microbiology – FURJ – Brazil. Dr. Francoise. Niellout – Facultyof. Pharmacy – Montpellier. University – France. Dr. Laurance. Vian – Facultyof. Pharmacy – Montpellier. University – France. Dr. Patricia. Dias Fernandes – Departmentof. Pharmacology – FURJ – Brazil. Dr. Maria Eline Matheus – Departmentof. Pharmacology – FURJ – Brazil. Dr. Nunziatina di Tommasi – Facultyof. Pharmacy – Salerno – Italy. Dr. Niko. Radulovic– Departmentof. Chemistry – Universityof. Nis – Serbia. Recent Publications: 1 - C. G. Silva, R. J. Raulino, D. M. Cerqueira, S. C. Mannarino, M. D. Pereira, A. D. Panek, J. F. M. Silva, F. S. Menezesand E. C. A. Eleutherio. In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptisfasciculata. doi: 10. 1016/j. phymed. 2008. 12. 019. 2 - Renno. MN. , Barbosa GN. , Zancan P. , Veiga VF. , Alviano CS. , Sola-Penna. M. , Menezes FS. , Holandino. C. Crude ethanol extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines. Annals of the Brazilian Academy of Science, 80(3): 467, 2008. 3 - Falcao DQ. , Costa ER. , Kuster RM. , Nielloud F. , Vian L. , Menezes FS. Evaluation of cytotoxicity, phototoxicity and genotoxicity from Calceolaria chelidonioides (Scrophulariaceae) flowers ethanol extract. Planta. Medica, 73(9): 973, 2007. 4 - Falcao DQ. , Costa ER. , Kuster RM. , Nielloud F. , Vian L. , Menezes FS. The obtention of an oil/water nanoemulsion containing the Calceolaria chelidonioidesflowers ethanol extract and its skin hydration power. Planta. Medica, 73(9): 1018, 2007. 5 - Matheus. ME. , Fernandes SBD. , Silveira CS. , Rodrigues VP. , Menezes FS. , Fernandes PD. Inhibitory effects of Euterpeoleracea. Mart. on nitric oxide production and i. NOSexpression. Journal of Ehtnopharmacology, 107(2): 291, 2006. 6 - Silva CG, Herdeiro RS, Mathias CJ, Panek AD, Silveira CS, Rodrigues VP, Renno MN, Falcao DQ, Cerqueira DM, Minto ABM, Nogueira FLP, Quaresma CH, Silva JFM, Menezes FS, Eleutherio. ECA. Evaluation of antioxidant activity of Brazilian plants. Pharmacological Research, 52(3): 229, 2005. 7 - Matheus ME, Berrondo LF, Vieitas EC, Menezes FS, Fernandes. PD. Evaluation of the antinociceptive properties from Brillantaisia palisotii Lindau stems extracts. Journal of Ethnopharmacology, 102(3): 377, 2005.