Dominant Recessive Genetic Disorders 11 1 State Standard

Dominant & Recessive Genetic Disorders (11. 1) State Standard 2 C. Using Mendel’s laws, explain the role of meiosis in reproductive variability. 2 D. Describe the relationships between changes in DNA and potential appearance of new traits

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Recessive Genetic Disorders § A recessive trait is expressed when the individual is ______ recessive for the ______. § A person who is heterozygous is called a ______.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Cystic Fibrosis (Recessive) § Common among ______ § Affects the ______ -producing glands, digestive ______, and sweat glands § Chloride ______ are not absorbed into the cells of a person with cystic fibrosis but are ______ in the sweat. § Without sufficient chloride ions in the cells, a thick ______ is secreted. § Treatment includes physical therapy, medication, & special diets.

A normal woman marries a man with cystic fibrosis. If they have children, what ratio will be totally normal? Explain.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Albinism (Recessive) § Caused by altered ______, resulting in the absence of the skin pigment ______ in ______, skin, and ______ § ______ e hair § Very pale ______ § ______ pupils § Sun’s ______ radiation is especially dangerous

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Albinism (Recessive)

An albino man marries a woman who is a carrier. Create a Punnett Square to show the possibilities of their offspring. Include genotypic & phenotypic ratios.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Tay-Sachs Disease (Recessive) § Recessive disorder on chromosome _______ § Caused by the absence of the ______ responsible for breaking down ____________ called gangliosides § Gangliosides accumulate in the ______, inflating brain nerve cells and causing mental ______. § Occurs predominantly in ______ of Eastern European descent.

A man & woman who are both Tay Sachs carriers get married & decide to have children. What percent chance is there of them having a purebred normal baby? Use a Punnett Square to determine your answer.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Galactosemia (Recessive) § Recessive genetic disorder characterized by the inability of the body to digest ______. § These people must avoid ______ products. § Milk products will cause numerous complications, including ______ disability.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Dominant Genetic Disorders § Because these disorders are caused by a ______ allele, they affect people who are homozygous dominant and people who are ______.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Huntington’s Disease (Dominant) § Huntington’s disease affects the ______ system. § Occurs in 1 in ______ humans. § Symptoms first appear between the ages of ______. § Symptoms include loss of ______ function, uncontrollable ______, and emotional disturbances.

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Huntington’s Disease (Dominant)

A woman who is hybrid for Huntington’s marries a man who is normal. What will be the genotypic & phenotypic ratios of their children?

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Achondroplasia (Dominant) § Achondroplasia is a genetic condition that causes ______ body size and limbs that are comparatively ______. § Most common form of ______. § Adult height of about ______ feet. § Normal life expectancy.

A man & woman who are both heterozygous for Achondroplasia have children. Can they have a normal child? Explain

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance ______ § A diagram that traces the ______ of a particular ______ through several generations

Label each part of the diagram below

Pedigree Challenge On your first day interning in the office of a human geneticist, a man with purple ears walks in. You questioned the man and wrote down the following family history. The man's mother and one of his sisters also had purple ears, but his father, his brother, and two other sisters had normal ears. The man and his normaleared wife had seven children, including four boys and three girls. Two girls and two boys had purple ears. Draw the family pedigree and indicate what form of inheritance that the purple-ear trait most likely follows. (Is it dominant or a recessive passed trait? )

Chapter 11 Complex Inheritance and Human Heredity 11. 1 Basic Patterns of Human Inheritance Inferring Genotypes § Knowing physical traits can determine what ______ an individual is most likely to have. Predicting Disorders § Record keeping helps scientists use pedigree analysis to study inheritance patterns, determine ______, and ascertain ______.