Does the presence of aortopathy in bicuspid aortic
Does the presence of aortopathy in bicuspid aortic valve patients increase the risk of aortopathy in their first degree relatives? Ana Zuasnabar, Rodolfo Citro, Michele Bellino, Hector Michelena, Gabriel Parma, Simon Body, Lucía Florio, Victor Dayan. Introduction Group 1 (50) Description Group 2 (53) p First degree relatives (FDR) of bicuspid aortic valve (BAV) patients are at increased risk for acquiring BAV or aortopathy. Although the risk for a FDR to have BAV has been assessed, there is little information as to the risk for acquiring aortopathy. Age (SD) 36. 5 (17. 9) 36. 1 (18. 5) 0. 903 Female (%) 22 (44) 27 (51) 0. 481 To evaluate the risk for acquiring aortopathy in FDR with tricuspid aortic valve (TAV) of BAV patients, depending on whether the proband with BAV have associated aortopathy or not. Height (cm) (SD) 163. 2 (14. 9) 162. 2 (21. 7) 0. 789 Weight (kg) (SD) 67. 2 (17. 5) 69. 9 (19. 5) 0. 449 Mild aortic stenosis (%) 2 (4) 1 (1. 9) 0. 535 Mild aortic regurgitation (%) 8 (16) 9 (17. 3) 0. 600 Annulus (mm) (SD) 22. 5 (3. 7) 23. 0 (3. 9) 0. 505 29. 1 (4. 2) 31. 4 (4. 9) 0. 010 * 26. 2 (4. 3) 26. 9 (4. 8) 0. 427 27. 9 (4. 2) 29. 7 (4. 5) 0. 046 * Purpose Methods In this international multicentric prospective study, patients with BAV were classified according to associated aortopathy or not. Aortopathy was defined as : annulus ≥ 14 mm/m 2; root ≥ 20 mm/m 2; sino-tubular junction (STJ) ≥ 16 mm/m 2; ascending aorta (AA) ≥ 17 mm/m 2. FDR of BAV patients without (Group 1) and with aortopathy (Group 2) were included. Clinical and echocardiographic evaluation was performed on all included FDR. g in nd ce ST J As ot Ro lu s * nu We included 107 FDR, only 4 (4%) had BAV. FDR from group 2 had larger aortic root and AA (Table). By indexed aortic diameters, FDR from group 2 had higher incidence for root aortopathy (Figure). Group 2 was predictor for root (OR=19. 6[95%CI: 1. 33 -333], p=0. 001) and AA aortopathy (OR=4. 2[95%CI: 1. 2 -14. 1], p=0. 045). * An Results 30 25 20 15 10 5 0 Root (mm) (SD) Proband with STJ (mm) (SD) Aortopathy No AA (mm) (SD) Yes Conclusions FDR with TAV of patients with BAV and aortopathy have increased risk for aortopathy of the root and ascending aorta.
ng ST J di ce n As ot Ro us nu l An 30 25 20 15 10 5 0 No Yes
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