Disinformation from Press Releases Peter Steele Current Patents

Disinformation from Press Releases? Peter Steele Current Patents Ltd London W 1 T 4 LB peter@current-patents. com www. current-patents. com Current Patents Ltd - ACS, San Diego, April 2001

Background 10, 000 pharma/biotech press releases analysed each year for Investigational Drugs database (IDdb) 10% with IP implications - four per day Analysis for technical intelligence by skilled analysts Current Patents Ltd - ACS, San Diego, April 2001

Grey Literature Formal Grey Journals Patents Technical Reports Meetings Advertisements Newspapers Brochures Broadcasts Analysts’ Briefings Annual Reports Press releases Current Patents Ltd - ACS, San Diego, April 2001

Grey Literature Formal Journals (Patents) Technical Reports Meetings Grey Patents Advertisements Newspapers Brochures Broadcasts Analysts’ Briefings Annual Reports Press releases Current Patents Ltd - ACS, San Diego, April 2001

Intelligence = Effort Press Releases DOLPHIN (Database of All Pharmaceutical Inventions) One analyst – 3 to 4 days/week Current Patents Ltd - ACS, San Diego, April 2001

Sources - general (1) • PR Newswire • Business Newswire • Canada Newswire Medical, Hospital and Biotech sections • Direct email from companies Current Patents Ltd - ACS, San Diego, April 2001

Sources - general (2) • CAS Chemical industry news www. cas. org/reuters/chemnews. html • Daily industry news, individually profiled www. office. com Current Patents Ltd - ACS, San Diego, April 2001

Sources - general (3) • Pharmaceutical News & Information www. coreynahman. com • Pharmalicensing www. pharmalicensing. com • Hoover’s Online www. hoovershbn. hoovers. com • Bioresearch Online www. news. bioresearchonline. com Current Patents Ltd - ACS, San Diego, April 2001

Sources - Patent • USPTO Official Gazette www. uspto. gov/web/offices/com/sol/og • UK Official Journal www. patent. gov. uk/patent/notices • Australian PO Decisions www. austlii. edu. au/au/cases/cth/APO • UK Court Judgements www. wood. ccta. gov. uk/courtser/judgements. nsf Current Patents Ltd - ACS, San Diego, April 2001

Country of Origin US UK Canada Germany Switzerland Others (NL, FR, IL, JP DK, SE, AT) 235 17 16 8 7 17 Current Patents Ltd - ACS, San Diego, April 2001

State of Origin CA NJ MA WA PA NY MD Others (16) 97 30 28 14 10 9 8 40 Current Patents Ltd - ACS, San Diego, April 2001

Multinationals’ PRs Issuing Party – 30/300 (10%) Second Party – 68/300 (23%) Non-Government – 68/200 (34%) Current Patents Ltd - ACS, San Diego, April 2001

Three or more PRs issued Abgenix, Antex Ariad Arqule Coulter Genzyme Incyte Maxygen Myriad Sci. Clone Viragen Vivus XTL Current Patents Ltd - ACS, San Diego, April 2001

Partnerships in Press Releases First (issuing) party with Second Party etc 67% Company with Company/Institution 33% Company with Government Agency 22% USPTO 11% FDA Current Patents Ltd - ACS, San Diego, April 2001

Technology Types 65% Fundamental (“platform”) 35% Product Oriented (69) Preclinical (21) Phase I (16) Phase II (12) Phase III (6) Marketed (14) Current Patents Ltd - ACS, San Diego, April 2001

Details to Cite Patent Number - get it right!!! Inventor Names Date and country of origin Identity of Originator – other interests? Name of Product/Technology Current Patents Ltd - ACS, San Diego, April 2001

Case Study (1): Immutech “……. announced today it had been issued US Patent No 6172104 B 1 entitled “Dicationic dibenzofuran……. . ” March 26, 2001 §Actually issued January 9, 2001 §Assignee is University of North Carolina §US Government (NIH) retains interest §Originates from joint program with Georgia, Duke & Auburn universities Current Patents Ltd - ACS, San Diego, April 2001

Case Study (2): “Interleukin Genetics… …. announced today that it was awarded Patent No 6210877 for the discovery that certain IL-1 gene variations…received a Notice of Allowance in June 2000” March 29, 2001 US 6210877 was not published until April 3, 2001 Published previously as PCT (WO 9840517, Sept 1998) June 2000 announcement referring to PCT would have been more helpful! Current Patents Ltd - ACS, San Diego, April 2001

Case Study (3): Roche…. . …receives EU approval for Herceptin…. . discovered and developed by Genentech…… Aug 30, 2000 Protein Design Labs and the US Army hold fundamental patents covering many humanized antibodies Genentech is a non-exclusive licensee of PDL Current Patents Ltd - ACS, San Diego, April 2001

Case Study (4): Abbott… …and Triangle Pharma…. results of phase I/II trial in which DAPD… UNC investigators conducting study…. DAPD claimed by Emory University in 1992 Emory has interference & opposition actions with Bio. Chem Pharma Current Patents Ltd - ACS, San Diego, April 2001

Press Releases: Conclusions Take nothing for granted Expect contradictions Expect old information Expect wrong numbers/dates……… Current Patents Ltd - ACS, San Diego, April 2001

“At best, a good press release can be an excellent source of technical intelligence – but that applies to only 10 -20% of examples……” Current Patents Ltd - ACS, San Diego, April 2001

“…. at worst there can be a lot of skilled effort required to extract and codify that intelligence, and sometimes there is nothing of substance to be said. ” Current Patents Ltd - ACS, San Diego, April 2001

Disinformation from Press Releases? Yes, if you’re not careful! Peter Steele Current Patents Ltd, London peter@current-patents. com www. current-patents. com Current Patents Ltd - ACS, San Diego, April 2001