Diseases of the Biliary Tract Victor Politi M

Diseases of the Biliary Tract Victor Politi, M. D. , FACP, Medical Director, SVCMC, School of Allied Health Professions, Physician Assistant Program

Cholelithiasis (Gallstones)

Cholelithiasis (Gallstones) z. Gallstone disease, or cholelithiasis, is one of the most common surgical problems worldwide. z. Gallstones are abnormal, inorganic masses formed in the gallbladder and, less commonly, in the common bile or hepatic ducts

z. They are a frequent cause of abdominal pain and dyspepsia.

z. Although gallstones can form anywhere in the biliary tree, the most common point of origin is within the gallbladder. z. Three types of gallstones exist: ypure cholesterol ypure pigment ymixed

z. Gallstones are classified according to their predominant chemical composition as either: ycholesterol ycalcium bilirubinate stones x< 20% of stone type in Europe & US x 30 -40% of stones in Japan

z. Three compounds comprise 80 -95% of the total solids dissolved in bile; yconjugated bile slats ylecithin ycholesterol

z. Under normal conditions, a delicate balance occurs among the levels of bile acids, cholesterol, and phospholipids. z. A disparity in this balance, especially with the supersaturation of cholesterol, predisposes patients to the formation of lithogenic bile and the subsequent development of cholesterol-type gallstones.

z. Pigmented gallstones are composed of calcium bilirubinate and appear in 2 major forms: black and brown.

z. Hemolysis and liver disease are associated with the black stones; zthe brown, earthy stones more frequently are formed outside the gallbladder and often are associated with bacterial infections of the biliary tract.

Mortality / Morbidity z. Related directly to the complications of the disease and its surgical treatment z. Approximately 10% patients with gallstones have common bile duct stones z. Gallstones can cause obstruction of the common bile duct, causing jaundice z. Cholangitis, a potentially life-threatening infection, can follow biliary obstruction

Mortality / Morbidity z Obstruction of the neck of the gallbladder causes bile stasis, which can lead to inflammation and edema of the gallbladder wall. z Sequelae of this condition include acute cholecystitis secondary to compromised lymphatic, venous, and, ultimately, arterial supply to the gallbladder. z The latter can lead to gangrene or abscess formation.

z. Women are more likely to develop gallstones than men, with a ratio of 2: 1. z. Classically, gallstones occur in obese, middle-aged women, which leads to the popular mnemonic, fat fertile forties.

History z Nausea, with or without vomiting, might be present. z Certain foods, especially those with high fat content, can provoke symptoms. z The patient might experience episodes of acute abdominal pain, called biliary colic.

Physical z. Murphy sign ypain on palpation of the right upper quadrant when the patient inhales might indicate acute cholecystitis z. Other signs of cholecystitis yfever ytachycardia

Complications of cholelithiasis z. The physical examination might indicate complications of cholelithiasis. y. Passage of gallstones from the gallbladder into the common bile duct can result in a complete or partial obstruction of the common bile duct. y. Frequently, this manifests as jaundice. y. In all races, jaundice is detected most reliably by examination of the sclera in natural for yellow discoloration.

Complications of cholelithiasis z. Pancreatitis, another complication of gallstone disease, presents with more diffuse abdominal pain, including pain in the epigastrium and left upper quadrant of the abdomen.

Complications of cholelithiasis z. Severe hemorrhagic pancreatitis occurs in 15% patients and carries a high mortality rate because of multisystem organ failure. z. In a few patients, the hemorrhagic pancreatic process and retroperitoneal bleeding induce discoloration around the umbilicus (Cullen sign) or the flank (Grey. Turner sign).

Complications of cholelithiasis y. Charcot triad x(right upper quadrant pain, fever, and jaundice) xassociated with common bile duct obstruction and cholangitis y. Additional symptoms: xalterations in mental status and hypotension, indicate Raynaud pentad, a harbinger of worsening, ascending cholangitis.

Causes of cholelithiasis z. Prolonged fasting (5 -10 days) can result in the formation of biliary sludge (microlithiasis) which resolves by itself when feeding is reestablished - but it can lead to biliary symptoms or gallstone formation

Lab Studies z. For patients with uncomplicated cholelithiasis, blood work results usually are normal. z. However, labs can detect complications of gallstone disease; complications might alter the course of treatment.

Lab Studies z. CBC zchemistry panel, including electrolytes, liver enzymes, and bilirubin. y. Choledocholithiasis can manifest with only elevation of serum alkaline phosphatase or bilirubin. y. Nearly 50% of patients with symptomatic gallstone disease will have abnormal transaminases

Lab Studies z. Serum lipase and amylase levels are helpful in cases of diagnostic uncertainty or suspected concurrent pancreatitis

Imaging Studies y. X-rays x. Approximately 15% of gallstones are radiopaque and can be visualized on plain x-ray. x. A porcelain gallbladder (heavily calcified) should be removed surgically because of increased risk of gallbladder cancer. x. Other causes of abdominal pain diagnosed with the assistance of x-rays include perforated viscus, bowel obstruction, calcific pancreatitis, and renal stones.

Imaging Studies y. Ultrasound (US) is the most sensitive and specific test for the detection of gallstones. y. US provides information about the size of the common bile duct and hepatic duct and the status of liver parenchyma and the pancreas. y. Thickening of the gallbladder wall and the presence of pericholecystic fluid are radiographic signs of acute cholecystitis

Imaging Studies y. CT scanning often is used in workup of abdominal pain without specific localizing signs or symptoms. y. CT scanning is not a first-line study for detection of gallstones because of greater cost and the invasive nature of the test. y. When present, gallstones usually are observed on CT scan.

Imaging Studies z HIDA scan does not detect gallstones z HIDA scan identifies an obstructed gallbladder (eg, gallstone impacted in the neck of the gallbladder). y. HIDA scan is the most sensitive and specific test for acute cholecystitis. y. A poorly contracting gallbladder (biliary dyskinesia) might cause the patient's symptoms, and HIDA scan makes the diagnosis. y. Acute acalculous cholecystitis is diagnosed most accurately with HIDA scan.

Treatment z. Removal of the gallbladder laparoscopic cholecystectomy is the treatment of choice for symptomatic gallbladder disease z. Only gallstones that cause symptoms or complications require treatment

Treatment z. There is generally no reason for prophylactic cholecystectomy in an asymptomatic person unless ythe gallbladder is calcified ygallstones are > 3 cm in diameter

Acute Cholecystitis

Acute Cholecystitis z. Cholecystitis is associated with gallstones in > 90% of cases y. Inflammation develops behind a stone impacted in the cystic duct z. May be caused by infectious agents (cytomegalovirus, cryptosporidiosis, or microsporidiosis) common in AIDS patients

z. Acalculous cholecystitis yshould be considered in patient with FUO, RUQ pain occurring 2 -4 weeks after major surgery

History z. Acute attack often follows a large, fatty meal zsudden, steady pain in epigastrium or right hypochondrium - pain may steadily subside over a period of 12 -18 hours zvomiting - 75% Of cases z. RUQ tenderness associated with muscle guarding and rebound pain

History z. Palpable gallbladder 15% of cases z. Jaundice 25% of cases yalso suggestive of choledocholithiasis z. Fever

Labs z. WBC - elevated (12 -15, 000 usuallly) z. Total serum bilirubin 1 -4 mg/d. L z. Often elevated levels of: yserum aminotransferase yalkaline phosphatase yserum amylase

Imaging Studies z. X-ray ymay show radiopaque gallstones 15% of cases z. HIDA Scan yuseful for obstructed cystic duct yreliable if bilirubin < 5 mg/d. L z. Ultrasound yuseful for gallstone visulization

Other Conditions z. Some disorders that may be confused with acute cholecystitis: yperforated peptic ulcer yacute pancreatitis yappendicitis (high lying appendix) yliver abscess yhepatitis ypneumonia w/pleurisy on right side ymyocardial ischemia

z. The localization of pain and tenderness in the right hypochondrium with radiation to the infrascapular area strongly favors the diagnosis of acute cholecystitis

Treatment z. Conservative tx regimen of y. TPN yanalgesics (Meperidine preferred drug- less spasm of sphincter of Oddi) yantibiotics

Treatment z. Due to high rate of recurrence zcholecystectomy advised ycholecystectomy must be performed when evidence of gangrene or perforation is present

Choledocholithiasis & Cholangitis

Choledocholithiasis z. Choledocholithiasis - common bile duct stones z. Occur in 15% of patients with gallstones z. Increases with age - in elderly w/gallstones occurrence as high as 50% z. Usually condition goes unknown until obstruction occurs

History z. History suggestive of biliary colic or jaudice zfrequent/recurrent attacks of severe RUQ pain- duration of several hours zsevere colic - chills/fever

History z. Charcot’s Triad- classic picture of cholangitis y. Pain y. Fever y. Chills

Imaging z. The most direct and accurate way to determine the cause, location, and extent of obstruction: y. ERCP ypercutaneous transhepatic cholangiography

Treatment z. Common duct stone in patient with cholelithiasis and cholecystitis is usually treated with endoscopic papillotomy and stone extraction - followed by laparoscopic cholcystectomy

Treatment z. Ciprofloxacin, 250 mg IV q 12 hours effective tx for cholangitis zalternative tx - mezlocillin, 3 g IV q 4 hours with either metronidazole or gentamicin or both z. Aminoglycosides should not be used for more than several days due to increased risk of aminoglycoside nephrotoxicity in cholestasis

Primary Sclerosing Cholangitis z. Rare disorder z. Characterized by diffuse inflammation of the biliary tract leading to fibrosis and strictures of the biliary system z. Most common - men aged 20 -40

Primary Sclerosing Cholangitis z. Associated with histocompatible antigens HLA-B 8 and -DR 3 or -DR 4 - suggestive of genetic etiologic role z. Sclerosing cholangitis may occur in AIDs patients from infections caused by CMV, cryptosporidium, or microsporum

Primary Sclerosing Cholangitis z. Symptoms yprogressive obstructive jaundice frequently associated with: xmalaise, pruritus, anorexia and indigestion x. Early detection in presymptomatic phase may occur due to elevated alkaline phosphatase level

Primary Sclerosing Cholangitis z. Complications of chronic cholestasis such as osteoporosis and malabsorption of fatsoluble vitamins may occur z. Diagnosis generally made by: y. ERCP ymagnetic resonance cholangiography

Primary Sclerosing Cholangitis z. Tx w/corticosteroids and broad spectrum antimicrobial agents yields inconsistent and unpredictable results z. Episodes of acute bacterial cholangitis may be treated with ciprofloxacin zhigh dose ursodeoxycholic acid (20 mg/kg/d) may reduce cholangiographic progression and liver fibrosis

Primary Sclerosing Cholangitis z. In patients with ulcerative colitis, primary sclerosing cholangitis is an independent risk factor for development of colorectal dysplasia and cancer- routine colonoscopic surveillance is advised

Primary Sclerosing Cholangitis z. For patients with cirrhosis and clinical decompensation, liver transplantation is the procedure of choice

Primary Sclerosing Cholangitis z. Survival of patients with primary sclerosing cholangitis averages 10 years once symptoms appear z. Adverse prognostic factors: yincreased age yincreased serum bilirubin yincreased aspartate aminotransferase levels ylow albumin levels yhistory of variceal bleeding

Carcinoma of the biliary tract

Carcinoma of Biliary Tract z. Occurs in 2% of people surgically treated for biliary disease z. Insidious onset - usually discovered during surgery z. Cholelithiasis usually present

Carcinoma of Biliary Tract z. Other risk factors: y. Chronic gallbladder infectionwith salmonella typhi ygallbladder polyps over 1 cm ymucosal calcification of the gallbladder (porcelain gallbladder) yanomalous pancreaticobiliary ductal junction

Carcinoma of Biliary Tract z. Carcinoma of the bile ducts (cholangiocarcinoma) accounts for 3% of all US cancer deaths z. Effects both sexes equally z. More prevalent 50 -70 age group

Carcinoma of Biliary Tract z 2/3 Klatskin tumors - arise at the confluence of hepatic ducts z 1/4 in the distal extrahepatic bile duct zremainder are intrahepatic

Carcinoma of Biliary Tract z. Signs/symptoms: y. Progressive jaundice ypain RUQ w/ pain radiating to back present in gallbladder CA but occurs later in course of bile duct carcinoma yanorexia, weight loss yfever, chills (due to cholangitis)

Carcinoma of Biliary Tract z. A palpable gallbladder w/obstructive jaundice usually is said to signify malignant disease (Courvoisier’s Law): however this has only proved to be accurate 50% of the time z. Hepatomegaly, liver tenderness z. Pruritus

Labs z. Conjugated hyperbilirubinemia zelevated alkaline phophatase zelevated serum cholesterol z. AST may be slightly elevated z. CA 19 -9 (elevated level can help distinguish cholangiocarcinoma from benign biliary stricture)

Imaging Studies z. Ultrasound z. CT z. MRI z. MRCP

Treatment z. Laparoscopic cholecystectomy y 5 year survival for localized carcinoma of the gallbladder is as high as 80% ysurvival rates drop dramatically with more extensive disease y. Carcinoma of the bile ducts is curable by surgery in < 10% of cases

z. Questions ?