Digital Pathology Empowering pathologists Bob van Gemen October

Digital Pathology Empowering pathologists Bob van Gemen October, 2008 1

Royal Philips Electronics • Founded in 1891 • Headquarters: Amsterdam, The Netherlands • One of the largest global diversified industrial company with sales in 2007 of EUR 26, 793 million • Multinational workforce of 123, 800 employees (January 2008) • Manufacturing sites in 28 countries, sales outlets in 150 countries • R&D expenditures EUR 1, 619 mln (2006) CONFIDENTIAL Healthcare Incubator 2

Since 1 Jan 2006, there are 3 Incubators within Philips to further New Business Development Healthcare Incubator Lifestyle Incubator Technology Incubator CONFIDENTIAL Healthcare Incubator 2

Strategic Focus Healthcare Incubator Philips Research Market Stage Future Growth HI Emerging Growth Established PD Roadmap, PD Incubation Sector Road Maps & Contract Research Current Emerging Philips capabilities CONFIDENTIAL Healthcare Incubator Potential Future

Incubation Process at Philips 1. Preseed 2. Seed 3. Alpha 4. Beta 5. Scaling Resea PH rch New BU in IEB Other Philips et g o t Spin her Ou tsi de Create value for Philips by 1. finding superior venture opportunities and 2. making them work CONFIDENTIAL , L LS C , Healthcare Incubator

Healthcare Incubator scope & selection criteria Scope • Involvement of medical profession • Medically validated solution required (e. g. FDA approval) Selection Criteria • Large market potential • Strong value proposition • Capable team • Strong IPR position • Link to Philips strategy • Venture can be run independent of Philips • There are synergies with Philips capabilities or assets CONFIDENTIAL Healthcare Incubator 6

Challenges in Pathology Baby Boomers, age distribution (USA) Pathology graduates decreasing More stains Lack of consensus 6% AAGR 16. 8% AAGR 70% accuracy among average pathologists CONFIDENTIAL Healthcare Incubator 7

Pathology oncology care cycle Radiology Clinic initiate diagnostic procedure Biopsy Image creation Pathologist Written report CONFIDENTIAL Image-based diagnostics Clinic: treatment advice Healthcare Incubator Radiologist PACS, RIS 8

Digital Pathology: empowering the pathologist Scanner Pathology Lab Path. Information System CAD CDS Expert pathologists PACS EPR CONFIDENTIAL Radiologist Oncologist Healthcare Incubator Medical Specialist 9

Value proposition Digital Pathology in Cancer Dx Quantification single IHC Value Radiology CDS Pathology CDS Morphology based CAD/CDS General CDS PACS Imaging Mod. CONFIDENTIAL Quantification multiple IHC Fast Scanner Healthcare Incubator Lab Dx

Data acquisition: importance of data processing • Even though a slide is “small”, imaging of biological specimens requires 100’s of millions of pixels. • Philips strength from Imaging in Radiology (e. g. whole body CT scan) • Better handling and viewing due to expertise from Radiology PACS CONFIDENTIAL Healthcare Incubator 11

Interesting possible solutions 1 2 3 4 Patient safety Advisor Productivity QA Clinical relevant solutions • follows clinical needs • development with clinical sites • scanner independent Technology basis • hardware and software • open system • enables clinical solutions CONFIDENTIAL Pathology PACS (viewer & storage) Digital scanner Healthcare Incubator 12

How to optimize the anatomic pathology workflow? 1. Single batch Slide production • Is a more continuous process more Diagnosis efficient? • What is the optimal workflow for scanning slides? 2. Small batches • Model with output in terms of: 3. Continuous CONFIDENTIAL 1. turn-around-times 2. lab equipment 3. human resources Healthcare Incubator

Development in collaboration with: • Pathology departments in 3 -4 of the top 10 cancer hospitals in USA • University Hospitals and Med Schools in USA • Same in Europe • Companies with synergistic technology CONFIDENTIAL Healthcare Incubator 14

Digital Pathology delivers benefits for Oncology Care Cycles Diagnostic turnaround time will be shortened to <24 hours Short term Objective, quantitative read out of (IHC) stains will improve patient safety Improved reporting of pathology data in EPR increases transparency of treatment choices for physicians and patients Application of CAD/CDS will improve overall consensus between pathologists and improved diagnostic result Long term New, Personalized Healthcare CAD/CDS, developed together with Pharma, will improve treatment response in breast cancer New Personalized Healthcare CAD/CDS, developed together with Pharma, will enable introduction of new, targeted treatment CONFIDENTIAL Healthcare Incubator 15