Different coding schemes in dorsal and ventral hippocampus
- Slides: 20
Different coding schemes in dorsal and ventral hippocampus Sebastien Royer Jagdish Patel
rodent primate cortex D V A Space representation Other-than-space representation P
Extrapolation from existing data d. MEC Prediction: giant place fields in VH small larger ? ? ? Jung et al. Hippocampus (1994) Hafting et al. Nature 2005 Maurer, Vanrhoads, Sutherland, Lipa, Mc. Naughton, Hippocampus 2005 Hafting et al. Science 2008
water port open field 7 -arm radial zig-zag maze
Absence of place cells in the ventral hippocampus? Dorsal CA 3 Ventral CA 3 1 m Discrete place fields, high peak firing rates Large, diffuse or multiple peak firing fields, low peak firing rates
Absence of place cells in the ventral hippocampus? Field size (# pixels) % area Field size (contour) % area spatial information stability (R: first half/second half) bits
Dorsal CA 3 neurons have small, single, direction -specific place fields (as in Mc. Naughton, Barnes, O’Keefe, Brain Res, 1983) n e u r o n # 1 329
Ventral CA 3 neurons fire on multiple-arms, in a direction-specific manner
v. CA 3 neurons fire on multiplearms % of arms # of active arms v. CA 3 neurons are more direction -specific than d. CA 3 % of cells v. CA 3 r
Ventral CA 3 neurons are arm type-specific (only on reward-bound journeys)
Ventral CA 3 population increases firing rate on reward-bound travels dorsal CA 3 ventral CA 3
3 dorsal CA 3 Ventral CA 3 neurons in the zig-zag maze respond to local geometrical features
right journey Firing fields of v. CA 3 neurons are larger and less directional left journey
Firing patterns of v. CA 3 neurons in the zig-zag maze reflect distances from the goal v. CA 3 R L int
Paucity of theta oscillations in ventral hippocampus
Paucity of theta-rhythmic v. CA 3 neurons d. CA 3 pyramidal cells 1313 v. CA 3 pyramidal cells 162 d. CA 3 interneurons 107 v. CA 3 interneurons 35
Fewer v. CA 3 neurons show phase precession v. CA 3 pyramidal cells d. CA 3 pyramidal cell
Differences between v. CA 3 and d. CA 3 • v. CA 3 neurons fired on multiple arms of the radial maze • firing fields of v. CA 3 often formed a ring (similar mechanisms in each arm) • v. CA 3 neurons differentiated between open and closed arms in the radial maze. • Both arm type differentiation and arm segment generalization (ring) of v CA 3 depended on the direction of travel • v. CA 3 neurons showed mirror-symmetric firing patterns in the zig-zag maze (distance from the goal) • cone-shaped place fields were exceptionally rare in v. CA 3 • LFP theta power in v. CA 3 was smaller than in d. CA 3 • Only a small fraction of v. CA 3 pyramidal cells and interneurons showed theta rhythmicity • Only a small fraction of v. CA 3 neurons showed phase precession
Hypothesis: Ventral hippocampus in the rat is functionally similar to pes and body of the primate hippocampus Dorsal hippocampus may be functionally similar to the tail pes/uncus body VH
CA 1 mol layer CA 1 Li, Somogyi, Ylinen, Buzsaki, J comp Neurol 1994 Differential CA 3 projections (ventral CA 3 strongly projects to granule cells)
- Contoh open coding
- Contoh open coding
- Ventral and dorsal
- Cockroach dorsal and ventral view
- Anatomical directions frog
- Dorsal vs ventral
- Horizontal plane
- Dorsal and ventral side
- Anterior meaning anatomy
- Deep anatomy definition
- Parietal mesoderm
- Viscer medical term
- Spinal cord
- Autonomic nervous system table
- Temporal difference
- Lateral recumbent position
- Posição ortostática
- Marine animals without a backbone
- Ventral e dorsal anatomia
- Dorsal cranial
- Upper limb