Diabetic Retinopathy Clinical Research Network DRCR net Dedicated

Diabetic Retinopathy Clinical Research Network (DRCR. net) Dedicated to multicenter clinical research of diabetic retinopathy, macular edema and associated disorders. 1

DRCR Network Overview Ø Objective: • Develop and operate a collaborative network to facilitate multicenter clinical research on diabetic retinopathy, diabetic macular edema and associated conditions. 2

ØThere have been 2716 subjects recruited for DRCR. net studies since the networks inception Ø 437 investigators have been certified for at least one protocol. 3

DRCR Network Overview Ø Funding: • • National Eye Institute (NEI) • Sponsored cooperative agreement initiated September 2002; initially through December 31, 2008 • Competitive renewal request every 5 years • Renewed from 2009 -2013 Industry collaborations Foundations (e. g. JDRF) Unrestricted gifts 4

Priority Initiatives Ø Involvement of community-based practices, as well as academic centers Ø Collaborate with industry to facilitate investigations and pursue opportunities otherwise not possible and to do so in a manner consistent with the Network’s dedication to academic integrity and optimal clinical trial performance 5

Network Organization Ø Coordinating Center • Roy Beck, M. D. , Ph. D. (Executive Director) • Adam Glassman, M. S. (Assistant Director) Ø Network Chair • Neil M. Bressler, M. D. (current) • Lloyd Paul Aiello, M. D. , Ph. D. (inaugural & past chair) Ø Network Vice-Chairs • Susan Bressler, M. D. • Scott Friedman, M. D. • Ingrid Scott, M. D. Ø NEI • Donald F. Everett, M. A. 6

Network Enrollment as of 9 -31 -09 Protocol # of Subjects A: A Pilot Study of Laser Photocoagulation for DME 319 B: A Randomized Trial Comparing Intravitreal Triamcinolone Acetonide and Laser Photocoagulation for DME 693 C: Temporal Variation in Optical Coherence Tomography Measurements of Retinal Thickening in DME 107 D: Evaluation of Vitrectomy for DME 241 E: A Pilot Study of Peribulbar Triamcinolone Acetonide for DME 113 F: An Observational Study of the Development of DME Following Scatter Laser Photocoagulation 155 G: Subclinical Diabetic Macular Edema Study 613 H: Phase 2 Randomized Trial of Bevacizumab for DME 121

Network Enrollment as of 9 -31 -09 Protocol # of Subjects I: Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for DME 691 J: Intravitreal Ranibizumab or Triamcinolone Acetonide as Adjunctive Treatment to Panretinal Photocoagulation for Proliferative Diabetic Retinopathy 333 K: The Course of Response to Focal Photocoagulation for DME 128 Currently Recruiting L: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema 209 O: Comparison of Time Domain OCT and Spectral Domain OCT Retinal Thickness Measurement in Diabetic Macular Edema 24 P: Pilot study in individuals with center-involved diabetic macular edema undergoing cataract surgery. Q: An observational study in individuals with diabetic retinopathy without center-involved diabetic macular edema undergoing cataract surgery. DRCR Network Study Subject Total 3, 747

For information about 1. Becoming a DRCR network investigator 2. Proposing collaborative clinical trial opportunities 3. A complete listing of DRCR publications 4. Or for other information E-mail drcrnet@jaeb. org 9